Mechanisms of Nfe2l1-linked inflammation and atherogenesis (B10)

• Subject Area: Endocrinology, Diabetology, Metabolism
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 238187445

Atherosclerosis and obesity are chronic inflammatory, metabolic disorders, in which aberrant metabolism is linked to the activation of the immune system and inflammation of the tissue. In this project, our objective is to identify mechanisms that link diet, obesity, and atherosclerosis through the cholesterol sensing transcription factor nuclear factor erythroid-2, like-1 (Nfe2l1) in adipocytes. By studying cultured adipocytes, preclinical transgenic mouse models, as well as implement short-wave infrared (SWIR) imaging, we will define the translational significance of Nfe2l1 for adipose inflammation and atherosclerosis.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 1123: Atherosclerosis: Mechanisms and Networks of Novel Therapeutic Targets
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Heads: Professor Dr. Alexander Bartelt; Dr. Oliver Bruns