Mechanisms of microglia-induced circuit remodeling in post-stroke recovery

• Applicants: Professor Dr. Arthur Liesz; Professor Dr. Tim Magnus; Professor Dr. Thomas Misgeld
• Subject Area: Molecular and Cellular Neurology and Neuropathology ; Molecular Biology and Physiology of Neurons and Glial Cells
• Term: since 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 405358801

The aim of this project is to investigate the mechanisms by which microglia promote recovery after acute stroke. We will adopt novel tools to modulate microglial function and study their impact on functional recovery and long-range neuronal connectivity. Specifically, we will focus on the role of microglia in modulating axon integrity and myelination during axonal reorganization and the ApoE-pathway of chronic microglial activation. For this we will combine complementary tools of in vivo imaging, genetic modification and ultrastructural analysis.

• DFG Programme: Research Units
• Subproject of: FOR 2879: ImmunoStroke: From immune cells to stroke recovery