Role of TPC2 in cellular signaling networks (P28#)

• Subject Area: Pharmacology
• Term: since 2023
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 239283807

Two pore channels (TPCs) are endo-lysosomal cation channels that belong to the TRP channel family. The proposal builds on preliminary work showing that TPC2s promote cardiac hypertrophy in mice and that their targeted deletion reduces disease severity. Interestingly, deletion of TPC2 promotes the release of exosomes from mouse cardiac fibroblasts. Moreover, exosomes from wild-type or TPC2-/- cardiac fibroblasts appear to contain increased levels of miRNAs that promote (WT exosomes) or prevent (TPC2-/- exosomes) cardiac hypertrophy/fibrosis. In three aims we will examine the hypothesis that TPC2s and exosomes individually and in concert regulate function in normal and diseased cardiac cells and tissues.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 152: TRiPs to Homeostasis: Maintenance of Body Homeostasis by Transient Receptor Potential Channel Modules
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professor Dr. Christian Wahl-Schott, since 7/2023