Die pathogenetische Bedeutung des Endotheltropismus aviärer Influenzaviren

• Antragsteller: Professor Dr. Hans-Dieter Klenk (†)
• Fachliche Zuordnung: Virologie
• Förderung: Förderung von 2002 bis 2010
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 5389385

• Erstellungsjahr: 2010

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Interdependence of hemagglutinin glycosylation and neuraminidase as regulators of influenza virus growth - A study by reverse genetics. J. Virol. 74, 6316-6323 (2000)
  Wagner, R., Wolff, T., Herwig, A., Pleschka, S., and Klenk, H.-D.
  
• Targeted infection of endothelial cells by the avian influenza virus A/FPV/ROSTOCK/34 (H7N1) in chicken embryos. J. Virol. 74, 8018-8027 (2000)
  Feldmann, A., Schäfer, M.K.-H., Garten, W., and Klenk, H.-D.
  
• Infection and activation of monocytes by Marburg and Ebola viruses. J.Virol. 75, 11025- 11033(2001)
  Ströher, U., West, E., Bugany, H., Klenk, H.-D., Schnittler, H.-J., and Feldmann, H.
  
• Targeted influenza virus infection of endothelial cells and leucocytes. In: Options for the Control of Influenza IV, International Congress Series, Elsevier Science B.V. 1219, 557-571 (2001)
  Feldmann, A., Looser, N., Wagner, R., and Hans-Dieter Klenk
  
• Functional balance between haemagglutinin and neuraminidase in influenza virus infections. Rev. Med. Virol. 12, 159-166 (2002)
  Wagner, R., Matrosovich, M., and Klenk, H.-D.
  
• Importance of hemagglutinin glycosylation for the biological functions of influenza virus. Virus Research 82, 73-75 (2002)
  Klenk, H.-D., Wagner, R., Heuer, D., and Wolff, T.
  
• N-Glycans attached to the stem domain of haemagglutinin efficiently regulate influenza A virus replication. J. Gen. Virol. 83, 601-609 (2002)
  Wagner, R., Heuer, D., Wolff, T., Herwig, A., and Klenk, H.-D.
  
• Acylation-mediated membrane anchoring of avian influenza virus hemagglutinin is essential for fusion pore formation and virus infectivity. J. Virol. 79, 6449-6458 (2005)
  Wagner, R., Herwig, A., Azzouz, N., and Klenk, H.-D.
  
• Infection of the endothelium by influenza viruses. Thrombosis and Haemostasis 94, 262-265 (2005)
  H.D. Klenk
  
• Live attennated recombinant vaccine protects non-human primates against either Ebola virus or Marburg virus. Nature Medicine 11, 786-90 (2005)
  Jones, S.M., Feldmann, H., Ströher, U., Geisbert, J.B., Fernando, L., Grolla, A., Klenk, H.- D., Sullivan, N.J., Volchkov, V.E., Fritz, E.A., Daddario, K.M., Hensley, L.A., Jährling, P.B., and Geisbert, T.W.
  
• The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. Proc. Natl. Acad. Sci. (USA) 102, 18590-95 (2005)
  Gabriel, G., Dauber, B., Wolff, T., Planz, O., Klenk, H.-D., and Stech, J.
  
• Receptor specificity, host-range and pathogenicity of influenza viruses. In: Influenza Virology: Current Topics, Horizon Press, pp 95-137(2006)
  Matrosovich, M., Klenk, H.-D. and Kawaoka, Y.
  
• Assessment of a vesicular stomatitis virus based vaccine using the mouse model of Ebola virus hemorrhagic fever. J. Inf. Dis. 196 (Suppl. 2), 404-412 (2007)
  Jones, S., Ströher, U., Fernando, L., Qiu, X., Alimonti, J., Melito, P., Bray, M., Klenk, H.-D., and Feldmann, H.
  
• Differential polymerase activity in avian and mammalian cells determines host range of influenza virus. J. Virol. 81, 9601-04 (2007)
  Gabriel, G., Abram, M., Keiner, B., Wagner, R., Klenk, H.-D., and Stech, J.
  
• Avian Influenza: molecular mechanisms of pathogenesis and host range. In: Animal Viruses: Molecular Biology (T.C Mettenleiter, F. Sobrino, eds.), pp. 253-301, Caister Academic Press (2008)
  Klenk, H.D., Matrosovich, M., and Stech, J.
  
• Cleavage activation of the influenza virus hemagglutinin and its role in pathogenesis. In: Avian Influenza, Monographs in Virology 27 (H.D. Klenk, M.N. Matrosovich, J. Stech, eds) pp 156-167, Karger, Basel (2008)
  Garten, W. and Klenk, H.D.
  
• Interaction of polymerase subunits PB2 and NP with importin α1 is a determinant of host range of influenza A virus. PloS Pathogens 4 (2): e11 (2008)
  Gabriel, G., Herwig, A., and Klenk, H.-D.
  (Siehe online unter https://doi.org/10.1371/journal.ppat.0040011)
• Receptor specificity of influenza viruses and its alteration during interspecies transmission. In: Avian Influenza, Monographs in Virology 27 (H.D. Klenk, M.N. Matrosovich, J. Stech, eds), pp 134-155, Karger, Basel (2008)
  Matrosovich, M.N.; Gambaryan, A.S., and Klenk, H.D.
  
• Influenza receptors, polymerase and host range, OIE Scientific and Technical Review 28 (1), 203-217 (2009)
  Matrosovich, M., Stech, J., and Klenk, H.D.
  
• Spread of infection and lymphocyte depletion in mice depends on polymerase of influenza virus. Am. J. Pathol. 175, 1178-1186(2009)
  Gabriel, G., Klingel, K., Planz, O., Bier, K., Herwig, A., Sauter, M., and Klenk, H.D.