Development of high resolution molecular imaging methods based on fluorescent and photoacoustic contrasts.

• Applicant: Professor Dr. Daniel Razansky
• Subject Area: Medical Physics, Biomedical Technology
• Term: from 2008 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 83780773

Imaging of pathogenesis in intact tissues at the molecular level based on interrogation of cellular and sub-cellular function is increasingly becoming a key technology in preclinical imaging of inflammation responses, early tumor detection and drug discovery and holds strong potential for large-scale clinical propagation as well. There are possibly several imaging approaches that can provide molecular information, but the optical spectrum may offer the most direct information on the molecular interactions in living organism through numerous fluorescence probing mechanisms. The main limitation of the current in-vivo imaging methods of fluorescent molecular probes in the visible and near-infrared is the poor spatial resolution resulting from rapid light diffusion in biological tissues at depths exceeding 1mm. The current project aims in developing new high resolution and high sensitivity molecular imaging methods for reconstruction of fluorescence bio-distribution deep in living tissues based on combination of optical and photoacoustic approaches.

• DFG Programme: Research Grants