Project Details
Projekt
Redox regulation of the Nox2 and B7-H1 mRNA stability (A03)
Subject Area
Public Health, Healthcare Research, Social and Occupational Medicine
Term
from 2009 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 61867463
Our previous studies identified the mRNA stability as a target of redox regulation. First goal of our project is the identification of the RNA binding protein (RBP) that regulates the sB7-H1 mRNA stability (RNA-IP and MS, COOP. Z01 project). Followed by the regulatory and functional analysis of the RBP. Second goal is the characterization of the potential redox regulation of the RBP SYNCRIP, identified in our previous studies as a NOX2-mRNA binding protein. Afterwards we use the established sepsis mouse model to investigate how the alteration of the expression of the analyzed RBPs, can modulate the expression of their target genes and whether this has an influence on the course of the desease.
DFG Programme
Collaborative Research Centres
Applicant Institution
Goethe-Universität Frankfurt am Main
Project Head
Professor Dr. Andreas von Knethen
