Project Details
Projekt
Hydrogen sulfide (H2S) as a regulator of redox homeostasis during glomerulonephritis (A07)
Subject Area
Pharmacology
Term
from 2009 to 2020
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 61867463
Various forms of inflammatory diseases are accompanied by a massive synthesis of redox-active mediators such as ROS, NO and H2S. We developed a method that allows the proteom-wide detection of hydropersulfides on cysteines as H2S-induced redox switches. The aim of this research project is to demonstrate the relevance of these thiol-based redox switches for glomerular nephropathies and cutaneous wound healing in suitable cell culture and animal models. The detailed knowledge of redox-modifications of cysteine residues as a concerted target of ROS, NO and H2S should help to elaborate therapeutic strategies for the treatment of inflammatory diseases.
DFG Programme
Collaborative Research Centres
Applicant Institution
Goethe-Universität Frankfurt am Main
Project Head
Professor Dr. Josef M. Pfeilschifter
