Reactivation of memory T-cells

• Applicant: Professor Dr. Wolfgang Kastenmüller
• Subject Area: Immunology
• Term: from 2009 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 111942887

• Final Report Year: 2011

Final Report Abstract

In summary, we have used a viral vaccine model to explore the role of Treg during anti-viral responses. Rather than broadly blunting the immune response, we find that Treg selectively limit the number of Teff generated while preserving the memory response. They do so by changing the amount of CD80 and CD86 displayed on DC and the availability of IL-2, which is required for the generation of short-lived effector cells. These results have important implications for vaccination and therapies against infectious diseases and cancer designed to target the Treg compartment and manipulate cell-mediated immunity for host benefit.

Publications

• The in situ dynamics of dendritic cell interactions. Eur J Immunol. 40:2103-6. 2010
  Kastenmuller, W., Gerner, M. Y, Germain R. N.
  
• Protective T cell immunity in mice following protein-TLR7/8 agonist-conjugate immunization requires aggregation, type I IFN, and multiple DC subsets. J Clin Invest. 2011 May 2;121(5):1782-96
  Kastenmuller, K., Wille-Reece, U., Lindsay R. W. B., Trager L. R., Darrah P. A., Flynn B. J., Becker M. R., Udey M. C., Clausen B. E., Igyarto B. Z., Kaplan D. H., Kastenmuller W., Germain R. N., and Seder R. A
  
• Regulatory T Cells Selectively Control CD8+ T Cell Effector Pool Size via IL-2 Restriction. J Immunol. 2011 Sep 15;187(6):3186-97
  Kastenmuller W., Gasteiger G, Subramanian N, Sparwasser T, Busch DH, Belkaid Y, Drexler I, Germain RN