Vascular-wall resident hematopoietic progenitors and their role in tumor vascularization by postnatal vasculogenesis

• Applicant: Professorin Dr. Derya Tilki
• Subject Area: Reproductive Medicine, Urology
• Term: from 2009 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 112270419

• Final Report Year: 2010

Final Report Abstract

Under stressful microenvironmental conditions, some but not all solid tumor cell lines require endothelialderived growth and survival signals. Targeting these signals may lead to alternate strategies for eliminating residual tumor present after optimal therapy. Besides this, a close collaboration with the Department of Urology of the Memorial Sloan-Kettering Cancer Center was established, where we worked on a multi-center study regarding bladder cancer. Altogether the research year was very productive and a great experience and exposure to high quality research.

Publications

• pT3 substaging is a prognostic indicator in lymph node negative urothelial carcinoma of the bladder. Journal of Urology; Aug;184(2):470‐4
  Tilki D, Svatek RS, Karakiewicz PI, Novara G, Seitz M, Sonpavde G, Gupta A, Kassouf W, Fradet Y, Vincenzo Ficarra, Skinner E, Lotan Y, Sagalowsky AI, Stief CG, Reich O, Shariat SF
  
• Emerging Biology of Vascular Wall Progenitor Cells in Health and Disease. Trends in Molecular Medicine; 15(11):501‐9, 2009
  Tilki D, Hohn HP, Ergün B, Rafii S, Ergün S
  
• Characteristics and outcomes of patients with clinical carcinoma in situ only treated with radical cystectomy: an international study of 243 patients. J of Urol; 183(5):1757‐63, 2010
  Tilki D, Reich O, Svatek RS, Karakiewicz PI, Kassouf W, Novara G, Ficarra V, Chade DC, Fritsche H, Gerwens N, Izawa JI, Lerner SP, Schoenberg M, Stief CG, Skinner E, Lotan Y, Sagalowsky AI, Shariat SF
  
• Characteristics and outcomes of patients with clinical T1 grade 3 urothelial carcinoma treated with radical cystectomy: results from an international cohort. Eur Urol; 57(2):300‐9, 2010
  Fritsche H, Burger M, Svatek RS, Jeldres C,Karakiewicz PI, Novara G, Skinner E, Denzinger S, Fradet Y, Isbarn H, Bastian PJ, Volkmer BG, Montorsi F, Kassouf W, Tilki D, Otto W, Capitanio U, Izawa JI, Ficarra V, Lerner S, Sagalowsky AI, Schoenberg M, Kamat A, Dinney CP, Lotan Y, Shariat SF
  
• Characteristics and outcomes of patients with pT4 urothelial carcinoma at radical cystectomy: a retrospective international study of 583 patients. J of Urol; 183(1):87‐93, 2010
  Tilki D, Svatek RS, Karakiewicz PI, Isbarn H, Reich O, Kassouf W, Fradet Y, Novara G, Fritsche H, Bastian PJ, Izawa JI, Stief CG, Ficarra V, Lerner SP, Schoenberg M, Dinney CP, Skinner E, Lotan Y, Sagalowsky AI, Shariat SF
  
• International Validation of the prognostic value of lymphovascular invasion in patients with radical cystectomy. BJU Int; 105(10):1402‐12, 2010
  Shariat SF, Svatek RS, Tilki D, Skinner E, Karakiewicz PI, Capitanio C, Bastian PJ, Volkmer BG, Kassouf W, Novara G, Fritsche H, Izawa JI, Ficarra V, Lerner SP, Sagalowsky AI, Schoenberg MP, Kamat AM, Dinney CP, Lotan Y, Marberger MJ, Fradet Y
  
• Mechanisms of endothelial trophic support of genitourinary tumors. American Association for Cancer Research (AACR) 101st Annual Meeting, 2010
  Liang J, Tilki D, Kobayashi H, Rafii S, Seandel M
  
• Nomogram aids clinical decision making after radical cystectomy. Nature Reviews Urology; 7(4):182‐4, 2010
  Shariat SF, Tilki D
  
• Soft Tissue Surgical Margin Status is a Powerful Predictor of Outcomes After Radical Cystectomy: A Multicenter Study of over 4,400 Patients. J of Urol; 183(6):2165‐70, 2010
  Novara G, Svatek RS, Karakiewicz PI, Skinner E, Ficarra V, Fradet Y, Lotan Y, Isbarn H, Capitanio U, Bastian PJ, Kassouf W, Fritsche HM, Izawa JI, Tilki D, Dinney CP, Lerner SP, Schoenberg S, Volkmer BG, Sagalowsky AI, Shariat SF
  
• Stage pT0 at radical cystectomy confers an improvement in survival: An international study of 4430 patients. Journal of Urology; 2010 Jul 17. Epub ahead of print
  Tilki D, Svatek RS, Novara G, Seitz M, Godoy G, Karakiewicz PI, Kassouf W, Fradet Y, Fritsche H, Sonpavde G, Izawa JI, Ficarra V, Lerner SP, Schoenberg M, Stief CG, Dinney CP, Skinner E, Lotan Y, Sagalowsky AI, Reich O, Shariat SF
  
• Validation of the AJCC TNM substaging of pT2 bladder cancer: deep muscle invasion is associated with significantly worse outcome. European Urology; 2010 Jan 20. Epub ahead of print
  Tilki D, Reich O, Karakiewicz PI, Novara G, Kassouf W, Ergün S, Fradet Y, Ficarra V, Sonpavde G, Stief CG, Skinner E, Svatek RS, Lotan Y, Sagalowsky AI, Shariat SF
  
• Vascular Wall‐resident Stem Cells. Histology and Histopathology; 25(5): 681‐9, 2010
  Klein D, Hohn HP, Kleff V, Tilki D, Ergün S