Biochemical dissection, functional characterization and regulatory cues of the assembly machinery for U snRNPs

• Applicants: Professor Dr. Utz Fischer; Professor Dr. Oliver Gruß
• Subject Area: Cell Biology
• Term: from 2009 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 119111219

• Final Report Year: 2021

No abstract available

Publications

• ProteoPlex: stability optimization of macromolecular complexes by sparse-matrix screening of chemical space (2015). Nature Methods 12 (9), 859-865
  Chari, Ashwin; Haselbach, David; Kirves, Jan-Martin; Ohmer, Juergen; Paknia, Elham; Fischer, Niels; Ganichkin, Oleg; Möller, Vanessa; Frye, Jeremiah J; Petzold, Georg; Jarvis, Marc; Tietzel, Michael; Grimm, Clemens; Peters, Jan-Michael; Schulman, Brenda A; Tittmann, Kai; Markl, Jürgen; Fischer, Utz & Stark, Holger
  
• The ribosome cooperates with the assembly chaperone pICln to initiate formation of snRNPs (2016). Cell Reports 16 (12), 3103-3112
  Paknia, Elham; Chari, Ashwin; Stark, Holger & Fischer, Utz
  
• Deciphering the mRNP code: RNA-bound determinants of post-transcriptional gene regulation (2017). TIBS 42 (5), 369-382
  Gehring, Niels H.; Wahle, Elmar & Fischer, Utz
  
• Impaired spliceosomal UsnRNP assembly leads to Sm mRNA down-regulation and Sm protein degradation (2017). Journal of Cell Biology 216 (8), 2391-2407
  Prusty, Archana Bairavasundaram; Meduri, Rajyalakshmi; Prusty, Bhupesh Kumar; Vanselow, Jens; Schlosser, Andreas & Fischer, Utz
  
• UsnRNP biogenesis: mechanisms and regulation (2017). Chromosoma 126 (5), 577-593
  Gruss, Oliver J.; Meduri, Rajyalakshmi; Schilling, Maximilian & Fischer, Utz
  
• Developmental epileptic encephalopathy with hypomyelination and brain atrophy associated with PTPN23 variants affecting the assembly of UsnRNPs (2018). Eur J Hum Genet 26 (10), 1502-1511
  Smigiel, Robert; Landsberg, Gerd; Schilling, Maximilian; Rydzanicz, Małgorzata; Pollak, Agnieszka; Walczak, Anna; Stodolak, Anna; Stawinski, Piotr; Mierzewska, Hanna; Sasiadek, Maria M.; Gruss, Oliver J. & Ploski, Rafal
  
• A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing (2019). PLoS genetics 15 (10), e1008460
  Chen, Tao; Zhang, Bin; Ziegenhals, Thomas; Prusty, Archana B.; Fröhler, Sebastian; Grimm, Clemens; Hu, Yuhui; Schaefke, Bernhard; Fang, Liang; Zhang, Min; Kraemer, Nadine; Kaindl, Angela M.; Fischer, Utz & Chen, Wei
  
• TOR signaling regulates liquid phase separation of the SMN complex governing snRNP biogenesis (2021) Cell Reports. 2021 Jun 22;35(12):109277
  Schilling, Maximilian; Prusty, Archana B.; Boysen, Björn; Oppermann, Felix S.; Riedel, Yannick L.; Husedzinovic, Alma; Rasouli, Homa; König, Angelika; Ramanathan, Pradhipa; Reymann, Jürgen; Erfle, Holger; Daub, Henrik; Fischer, Utz & Gruss, Oliver J.