Reduktion der Arrhythmogenität nach Transplantation von Myoblasten durch Gentransfer mit Connexinen in vitro (Ko-Kultivierung von Myoblasten und neonatalen Rattenkardiomyozyten in einem monolayer Zellkulturmodell) und in vivo (Herzinfarktmodell am Schwein).

• Applicant: Dr. Andreas Barth
• Subject Area: Cardiology, Angiology
• Term: from 2005 to 2009
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 12528996

• Final Report Year: 2008

Final Report Abstract

No abstract available

Publications

• Gene transfer of a synthetic pacemaker channel into the heart: a novel strategy for biological pacing. Circulation. 2006 Oct 17;114(16):1682-6
  Kashiwakura Y, Cho HC, Barth AS, Azene E, Marbán E
  
• Identification of a Common Gene Expression Signature in Dilated Cardiomyopathy Across Independent Microarray Studies. Journal of the American College of Cardiology. J Am Coll Cardiol. 2006 Oct 17;48(8):1610-7
  Barth AS, Kuner R, Buneß A, Ruschhaupt M, Merk S, Zwermann L, Kääb S, Kreuzer E, Steinbeck G, Mansmann U, Poustka A, Näbauer M, Sültmann H
  
• MAPK= mitogen-activated protein KChlP2? Unraveling signaling pathways controlling cardiac Ito expression. Circulation Research. 2006;98(3):301-2
  Barth AS, Kääb S
  
• The potential for the transcriptome to serve as a clinical biomarker for cardiovascular diseases. Circulation Research. 2006;98(12):1459-61
  Barth AS, Hare JM
  
• Lentiviral vector-mediated expression of GFP or Kir2.1 alters the electrophysiology of neonatal rat ventricular myocytes without inducing cytotoxicity. Am J Physiol Heart Circ Physiol. 2007; 293(5):H2757-70
  Sekar RB, Kizana E, Smith RR, Barth AS, Zhang Y, Marbán E, Tung L
  
• CAPON modulates cardiac repolarization via neuronal nitric oxide synthase signaling in the heart. Proc Natl Acad Sci USA. 2008;105(11):4477-82
  Chang KC, Barth AS, Sasano T, Kizana E, Kashiwakura Y, Zhang Y, Foster DB, Marbán E
  
• Lentiviral vectors bearing the cardiac promoter of the Na+-Ca2+ exchanger report cardiogenic differentiation in stem cells. Molecular Therapy. 2008 Mar 18; [Epub ahead of print]
  Barth AS, Kizana E, Smith RR, Terrovitis J, Dong P, Leppo MK, Zhang Y, Miake J, Olson EN, Schneider JW, Abraham MR, Marbán E