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Influence of artificial and native extracellular matrices on adhesion and differentiation of mesenchymal stem cells and osteoblasts (B01)

Subject Area Orthopaedics, Traumatology, Reconstructive Surgery
Cell Biology
Term from 2009 to 2021
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 59307082
 
U. Hempel postulates that the pro-osteogenic effect of aECM/sGAG derivatives on MSC and osteoblasts is also due to changes in endogenous ECM (nECM). Therefore, sGAG-induced changes in the structure, composition and mechanics of the nECM as well as the phosphorylation status of ECM proteins will be characterized. On the other hand, intracellular interaction partners and signaling pathways of sGAG derivatives will be analyzed. Finally it will be studied whether aECM supports the osteogenic differentiation of hMSC from hair follicles and support hMSC from patients with impaired bone healing.
DFG Programme CRC/Transregios
Applicant Institution Universität Leipzig
Project Head Dr. Ute Hempel
 
 

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