A therapeutic approach to enhance innate defense mechanisms against toxins and venoms - mast cell proteases to the rescue

• Applicant: Professor Dr. Martin Metz
• Subject Area: Dermatology
• Term: from 2009 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 125440970

• Final Report Year: 2019

No abstract available

Publications

• Mast cells orchestrate type 2 immunity to helminths through regulation of tissue derived cytokines. PNAS 2012;109:6644-9
  Hepworth, Matthew R.; Daniłowicz-Luebert, Emilia; Rausch, Sebastian; Metz, Martin; Klotz, Christian; Maurer, Marcus & Hartmann, Susanne
  
• A beneficial role for immunoglobulin E in host defense against honeybee venom. Immunity 2013;39:963-75
  Marichal, Thomas; Starkl, Philipp; Reber, Laurent L.; Kalesnikoff, Janet; Oettgen, Hans C.; Tsai, Mindy; Metz, Martin & Galli, Stephen J.
  
• Mast Cells Limit the Exacerbation of Chronic Allergic Contact Dermatitis in Response to Repeated Allergen Exposure. J Immunol, 2016;197:4240-4246
  Gimenez-Rivera, Vladimir-Andrey; Siebenhaar, Frank; Zimmermann, Carolin; Siiskonen, Hanna; Metz, Martin & Maurer, Marcus
  
• Human Mast Cell Tryptase Is a Potential Treatment for Snakebite Envenoming Across Multiple Snake Species. Front Immunol, 2018; 9:1532
  Anderson, Elizabeth; Stavenhagen, Kathrin; Kolarich, Daniel; Sommerhoff, Christian P.; Maurer, Marcus & Metz, Martin