GRK 1326:  Calcium-Signale und zelluläre Nanodomänen

• Fachliche Zuordnung: Medizin
• Förderung: Förderung von 2006 bis 2015
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 13307018

• Erstellungsjahr: 2015

Zusammenfassung der Projektergebnisse

Das Graduiertenkolleg 1326 hat sich mit seiner Einrichtung im April 2006 einer konsequenten Verbesserung und Weiterentwicklung der Doktorandenförderung an der Medizinischen Fakultät verpflichtet. Ziel ist es, hochqualifizierte Nachwuchswissenschaftler auf dem zukunftsträchtigen Forschungsfeld intrazellulärer Calcium-Signale auszubilden. Der Forschungsverbund wird von einer Gruppe ausgewiesener WissenschaftlerInnen getragen, die sich methodisch an der rasanten Entwicklung bildgebender Messverfahren, dem zunehmenden Einsatz fluoreszierender Sonden sowie der wachsenden Zahl Ca2+- transportierender Strukturen orientiert und, thematisch fokussiert, die Funktionsanalyse Ca2+- regulierter Signalprozesse vorantreibt. Im Zentrum der Doktorarbeiten stehen Registrierungen des Echtzeitverlaufs zellulärer Ca2+-Signale, ihre räumliche Ausbreitung und Wechselwirkung mit Domänen Ca2+-transportierender und Ca2+-bindender Proteine. Dieses hochaktuelle Forschungsprogramm wird durch ein leistungsorientiertes Studienprogramm ergänzt, das den Kollegiaten praxis-relevante und fächerübergreifende Kenntnisse vermittelt. Die Ausbildung strebt eine breite fachliche Kompetenz der Kollegteilnehmer in molekulargenetischen, biochemischen und zellbiologischen Techniken an. Somit ist es gelungen, die Dichte des Nachwuchses auf diesem Arbeitsgebiet zu steigern, seine Konkurrenzfähigkeit im nationalen und internationalen Vergleich zu stärken, und gleichzeitig die Attraktivität des Standorts mit seinen bestehenden und weiterzuentwickelnden, interdisziplinären Forschungsschwerpunkten zu erhöhen.

Projektbezogene Publikationen (Auswahl)

• (2006). Trafficking and assembly of the cold-sensitive TRPM8 channel. J Biol Chem 281, 38396-404
  Erler, Isabell; Al-Ansary, Dalia M.M.; Wissenbach, Ulrich; Wagner, Thomas F.J.; Flockerzi, Veit & Niemeyer, Barbara A.
  
• (2008). Multiple RIBEYE–RIBEYE Interactions Create a Dynamic Scaffold for the Formation of Synaptic Ribbons. J Neurosci 28: 7954- 7967
  Magupalli, Venkat Giri; Schwarz, Karin; Alpadi, Kannan; Natarajan, Sivaraman; Seigel, Gail M. & Schmitz, Frank
  
• (2009). Analysis of the membrane proteome of canine pancreatic rough microsomes identifies a novel Hsp40, termed ERj7. Proteomics, Proteomics 9, 3463-3473
  Zahedi, René P.; Völzing, Christian; Schmitt, Andreas; Frien, Michael; Jung, Martin; Dudek, Johanna; Wortelkamp, Stefanie; Sickmann, Albert & Zimmermann, Richard
  
• (2009). Isolation and Genetic Manipulation of Adult Cardiac Myocytes for Confocal Imaging. Journal of Visual Experiments
  Kaestner, Lars; Scholz, Anke; Hammer, Karin; Vecerdea, Anne; Ruppenthal, Sandra & Lipp, Peter
  
• (2009). TRCP5 is a Ca 2+-Avtivated channel functionally coupled to Ca 2+ - Selective Ion Channels. J Biol Chem 284, 34423-32
  Gross, Stefan Alfred; Guzmán, Gustavo Adolfo; Wissenbach, Ulrich; Philipp, Stephan Ernst; Zhu, Michael Xi; Bruns, Dieter & Cavalié, Adolfo
  
• (2010). ATP modulates Ca2+ uptake by TRPV6 and is counteracted by isoform-specific phosphorylation. FASEB J 2: 425- 435
  Al‐Ansary, Dalia; Bogeski, Ivan; Disteldorf, Barbara M. J.; Becherer, Ute & Niemeyer, Barbara A.
  
• (2010). Properties of the intracellular transient receptor potential (TRP) channel in yeast, Yvc1. FEBS Lett. 584, 2028-2032
  Chang, Yiming; Schlenstedt, Gabriel; Flockerzi, Veit & Beck, Andreas
  
• Charakterisierung von Interaktionen der Hsp-Proteine Sec63p und ERj7p. (2009), Medizinische Fakultät, Dissertation Universität des Saarlandes
  Schmitt A
  
• (2010). Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling. Sci Signal 3: ra27
  Bogeski, Ivan; Kummerow, Carsten; Al-Ansary, Dalia; Schwarz, Eva C.; Koehler, Richard; Kozai, Daisuke; Takahashi, Nobuaki; Peinelt, Christine; Griesemer, Desiree; Bozem, Monika; Mori, Yasuo; Hoth, Markus & Niemeyer, Barbara A.
  
• (2010). Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. Journal of Clinical Investigation, 120: 3267-79
  Mathar, Ilka; Vennekens, Rudi; Meissner, Marcel; Kees, Frieder; Van der Mieren, Gerry; Camacho Londoño, Juan E.; Uhl, Sebastian; Voets, Thomas; Hummel, Björn; van den Bergh, An; Herijgers, Paul; Nilius, Bernd; Flockerzi, Veit; Schweda, Frank & Freichel, Marc
  
• (2010). NAD(H)-dependent binding of the neuronal Ca2+-sensor protein GCAP2 to photoreceptor synaptic ribbons. J. Neurosci., 30(19):6559-76
  Venkatesan, Jagadeesh Kumar; Natarajan, Sivaraman; Schwarz, Karin; Mayer, Sabine I.; Alpadi, Kannan; Magupalli, Venkat Giri; Sung, Ching-Hwa & Schmitz, Frank
  
• (2010). Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Res Cardiol. 105: 583-95
  Klaiber, Michael; Kruse, Martin; Völker, Katharina; Schröter, Juliane; Feil, Robert; Freichel, Marc; Gerling, Andrea; Feil, Susanne; Dietrich, Alexander; Londoño, Juan Eduardo Camacho; Baba, Hideo A.; Abramowitz, Joel; Birnbaumer, Lutz; Penninger, Josef M.; Pongs, Olaf & Kuhn, Michaela
  
• (2010). Pharmacology of ORAI channels as a tool to understand their physiological functions. Expert Review of Clinical Pharmacology, 3, 291-303
  Bogeski, Ivan; Al-Ansary, Dalia; Qu, Bin; Niemeyer, Barbara A; Hoth, Markus & Peinelt, Christine
  
• (2010). Pharmacology of ORAI channels as a tool to understand their physiological functions. Expert Reviews of Clinical Pharmacology 3: 291-303
  Bogeski, Ivan; Al-Ansary, Dalia; Qu, Bin; Niemeyer, Barbara A; Hoth, Markus & Peinelt, Christine
  
• (2010). SNARE force synchronizes synaptic vesicle fusion and controls the kinetics of quantal synaptic transmission. J Neurosci 30, 10272- 81
  Guzman, Raul E.; Schwarz, Yvonne N.; Rettig, Jens & Bruns, Dieter
  
• (2010). TRPM channels mediate zinc homeostasis and cellular growth during Drosophila larval development. Cell Metab. 12(4):386-97
  Georgiev, Plamen; Okkenhaug, Hanneke; Drews, Anna; Wright, David; Lambert, Sachar; Flick, Melanie; Carta, Valentina; Martel, Cecile; Oberwinkler, Johannes & Raghu, Padinjat
  
• (2010). TRPM3 channels provide a regulated influx pathway for zinc in pancreatic beta cells. Pflugers Arch. 460 (4): 755-765
  Wagner, Thomas F. J.; Drews, Anna; Loch, Sabine; Mohr, Florian; Philipp, Stephan E.; Lambert, Sachar & Oberwinkler, Johannes
  
• (2010). TRPM3 channels provide a regulated influx pathway for zinc in pancreatic beta cells. Pflugers Arch. 460(4):755-65
  Wagner, Thomas F. J.; Drews, Anna; Loch, Sabine; Mohr, Florian; Philipp, Stephan E.; Lambert, Sachar & Oberwinkler, Johannes
  
• Characterization of the Vacuolar Ion Channel Yvc1 in Saccharomyces cerevisiae. (2010) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Chang Y
  
• High Resolution 3D-Imaging of the Physiology and Morphology of Isolated Adult Cardiac Myocytes from Rat and Mice. (2010) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Hammer K
  
• Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. Journal of Clinical Investigation, 120: 3267-79
  Mathar, Ilka; Vennekens, Rudi; Meissner, Marcel; Kees, Frieder; Van der Mieren, Gerry; Camacho Londoño, Juan E.; Uhl, Sebastian; Voets, Thomas; Hummel, Björn; van den Bergh, An; Herijgers, Paul; Nilius, Bernd; Flockerzi, Veit; Schweda, Frank & Freichel, Marc
  
• Regulatory mechanisms of the calcium selective ion channels TRPV6 and ORAI1. (2010) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Al-Ansary A
  
• Syntaxin7 is required for lytic granule release from cytotoxic T- lymphocytes. (2010) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Pattu V
  
• Vti1b-dependent interaction between lytic granules and recycling TCR compartments is required for efficient function of cytotoxic T lymphocytes. (2010) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Qu B
  
• (2011). Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate localcalcium signals for T-cell activation. EMBO J 2011; 30(19):3895-912
  Quintana, Ariel; Pasche, Mathias; Junker, Christian; Al-Ansary, Dalia; Rieger, Heiko; Kummerow, Carsten; Nuñez, Lucia; Villalobos, Carlos; Meraner, Paul; Becherer, Ute; Rettig, Jens; Niemeyer, Barbara A & Hoth, Markus
  
• (2011). Docking of Lytic Granules at the Immunological Synapse in Human CTL Requires Vti1b-Dependent Pairing with CD3 Endosomes. J Immunol 186 (12): 6894-6904
  Qu, Bin; Pattu, Varsha; Junker, Christian; Schwarz, Eva C.; Bhat, Shruthi S.; Kummerow, Carsten; Marshall, Misty; Matti, Ulf; Neumann, Frank; Pfreundschuh, Michael; Becherer, Ute; Rieger, Heiko; Rettig, Jens & Hoth, Markus
  
• (2011). Docking of lytic granules at the immunological synapse in human CTL requires Vti1b-dependent pairing with TCR endosomes. J Immunol 186, 6894-6904
  Qu B, Pattu V, Junker C, Schwarz EC, Marshall M, Matti U, Becherer U, Bhat SS, Kummerow C, Neumann F, Pfreundschuh M, Rieger H, Rettig J, Hoth M
  
• (2011). Docking of lytic granules at the immunological synapse in human CTL requires Vti1b-dependent pairing with TCR endosomes. J Immunol 186, 6894-6904
  Qu, Bin; Pattu, Varsha; Junker, Christian; Schwarz, Eva C.; Bhat, Shruthi S.; Kummerow, Carsten; Marshall, Misty; Matti, Ulf; Neumann, Frank; Pfreundschuh, Michael; Becherer, Ute; Rieger, Heiko; Rettig, Jens & Hoth, Markus
  
• (2011). Loss-of-function mutations in sodium channel Nav1.7 cause anosmia.Nature 472, 186 – 190
  Weiss, Jan; Pyrski, Martina; Jacobi, Eric; Bufe, Bernd; Willnecker, Vivienne; Schick, Bernhard; Zizzari, Philippe; Gossage, Samuel J.; Greer, Charles A.; Leinders-Zufall, Trese; Woods, C. Geoffrey; Wood, John N. & Zufall, Frank
  
• (2011). Moderate Calcium Channel Dysfunction in Adult Mice with Inducible Cardiomyocyte-specific Excision of the cacnb2 Gene. J Biol Chem. 286: 15875-82
  Meissner, Marcel; Weissgerber, Petra; Londoño, Juan E. Camacho; Prenen, Jean; Link, Sabine; Ruppenthal, Sandra; Molkentin, Jeffery D.; Lipp, Peter; Nilius, Bernd; Freichel, Marc & Flockerzi, Veit
  
• (2011). ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance. Cell Calcium
  Qu, Bin; Al-Ansary, Dalia; Kummerow, Carsten; Hoth, Markus & Schwarz, Eva C.
  
• (2011). ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance. Cell Calcium 50: 261-269
  Qu, Bin; Al-Ansary, Dalia; Kummerow, Carsten; Hoth, Markus & Schwarz, Eva C.
  
• (2011). Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes. Traffic 12 (7): 890-901
  Pattu, Varsha; Qu, Bin; Marshall, Misty; Becherer, Ute; Junker, Christian; Matti, Ulf; Schwarz, Eva C.; Krause, Elmar; Hoth, Markus & Rettig, Jens
  
• (2011). Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes. Traffic 12, 890-912
  Pattu, Varsha; Qu, Bin; Marshall, Misty; Becherer, Ute; Junker, Christian; Matti, Ulf; Schwarz, Eva C.; Krause, Elmar; Hoth, Markus & Rettig, Jens
  
• (2011). The Synaptic Ribbon Is a Site of Phosphatidic Acid Generation in Ribbon Synapses, J. Neurosci.; 31(44): 15996-16011
  Schwarz, Karin; Natarajan, Sivaraman; Kassas, Nawal; Vitale, Nicolas & Schmitz, Frank
  
• (2011). Transient receptor potential melastatin 1 (TRPM1) is an ionconducting plasma membrane channel inhibited by zinc ions. J Biol Chem. 286(14):12221-33
  Lambert, Sachar; Drews, Anna; Rizun, Oleksandr; Wagner, Thomas F.J.; Lis, Annette; Mannebach, Stefanie; Plant, Sandra; Portz, Melanie; Meissner, Marcel; Philipp, Stephan E. & Oberwinkler, Johannes
  
• A Biopolar Cell Culture of the Mouse Retina to Study Ribbon Synapses. (2011) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Natarajan S
  
• Elektrophysiologische Charakterisierung der murinen Ionenkanäle TRPM1 und TRPM3 und des TRPM Kanals von Drosophila melanogaster“, (2011) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Drews A
  
• Role of TRPC-channels in cardiac hypertrophy and platelet aggregation: Analysis of TRPC-deficient mice. (2011) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Camacho-Londoňo JE
  
• (2010). Remodelling of Ca2+ handling organelles in adult rat ventricular myocytes during longterm culture. JMCC 49: 427-437
  Kaestner, Lars
  
• (2012). Alternative Splicing of a Protein Domain Indispensable for Function of Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channels. J Biol Chem 287, 36663-36672
  Frühwald, Julia; Camacho Londoño, Julia; Dembla, Sandeep; Mannebach, Stefanie; Lis, Annette; Drews, Anna; Wissenbach, Ulrich; Oberwinkler, Johannes & Philipp, Stephan E.
  
• (2012). Alternative splicing of a protein domain indispensable for function of transient receptor potential melastatin 3 (TRPM3) ion channels. J Biol Chem.
  Frühwald, Julia; Camacho Londoño, Julia; Dembla, Sandeep; Mannebach, Stefanie; Lis, Annette; Drews, Anna; Wissenbach, Ulrich; Oberwinkler, Johannes & Philipp, Stephan E.
  
• (2012). Alternative splicing of a protein domain indispensable for function of transient receptor potential melastatin 3 (TRPM3) ion channels. J Biol Chem. 287(44):36663-72
  Frühwald, Julia; Camacho Londoño, Julia; Dembla, Sandeep; Mannebach, Stefanie; Lis, Annette; Drews, Anna; Wissenbach, Ulrich; Oberwinkler, Johannes & Philipp, Stephan E.
  
• (2012). BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER. EMBO J 31 3282-3296
  Schäuble, Nico; Lang, Sven; Jung, Martin; Cappel, Sabine; Schorr, Stefan; Ulucan, Özlem; Linxweiler, Johannes; Dudek, Johanna; Blum, Robert; Helms, Volkhard; Paton, Adrienne W; Paton, James C; Cavalié, Adolfo & Zimmermann, Richard
  
• (2012). Different effects of Sec61alpha, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci 125 1958-1969
  Lang, Sven; Benedix, Julia; Fedeles, Sorin V.; Schorr, Stefan; Schirra, Claudia; Schäuble, Nico; Jalal, Carolin; Greiner, Markus; Haßdenteufel, Sarah; Tatzelt, Jörg; Kreutzer, Birgit; Edelmann, Ludwig; Krause, Elmar; Rettig, Jens; Somlo, Stefan; Zimmermann, Richard & Dudek, Johanna
  
• (2012). EF handmediated Ca and cGMP signaling in photoreceptor synaptic terminals, Front Mol Neurosci. 2012;5:26. Epub
  Schmitz, Frank; Natarajan, Sivaraman; Venkatesan, Jagadeesh K.; Wahl, Silke; Schwarz, Karin & Grabner, Chad P.
  
• (2012). Functional and morphological preservation of adult ventricular myocytes in culture by sub-micromolar cytochalasin D supplement. J Mol Cell Cardiol. 52(1):113-24
  Tian, Qinghai; Pahlavan, Sara; Oleinikow, Katharina; Jung, Jennifer; Ruppenthal, Sandra; Scholz, Anke; Schumann, Christian; Kraegeloh, Annette; Oberhofer, Martin; Lipp, Peter & Kaestner, Lars
  
• (2012). Gαq and Gα11 contribute to the maintenance of cellular electrophysiology and Ca2+ handling in ventricular cardiomyocytes. Cardiovasc Res. 95(1):48-58
  Pahlavan, Sara; Oberhofer, Martin; Sauer, Benjamin; Ruppenthal, Sandra; Tian, Qinghai; Scholz, Anke; Kaestner, Lars & Lipp, Peter
  
• (2012). Membrane-proximal tryptophans of synaptobrevinII stabilize priming of secretory vesicles. J. Neurosci. 32(45),15983-97
  Borisovska, Maria; Schwarz, Yvonne N.; Dhara, Madhurima; Yarzagaray, Antonio; Hugo, Sandra; Narzi, Daniele; Siu, Shirley W. I.; Kesavan, Jaideep; Mohrmann, Ralf; Böckmann, Rainer A. & Bruns, Dieter
  
• (2012). Membrane-proximal tryptophans of synaptobrevinII stabilize priming of secretory vesicles. J. Neurosci. 32(45),15983-97
  Borisovska, Maria; Schwarz, Yvonne N.; Dhara, Madhurima; Yarzagaray, Antonio; Hugo, Sandra; Narzi, Daniele; Siu, Shirley W. I.; Kesavan, Jaideep; Mohrmann, Ralf; Böckmann, Rainer A. & Bruns, Dieter
  
• (2012). Mutation of the CaV1.2 IQ Motif to CaV1.2 EQ induces dilated Cardiomyopathy and Death. J Biol Chem. 287(27):22616-25
  Blaich, Anne; Pahlavan, Sara; Tian, Qinghai; Oberhofer, Martin; Poomvanicha, Montatip; Lenhardt, Peter; Domes, Katrin; Wegener, Jörg W.; Moosmang, Sven; Ruppenthal, Sandra; Scholz, Anke; Lipp, Peter & Hofmann, Franz
  
• (2012). SNARE protein expression and localization in human cytotoxic lymphocytes. Eur J Immunol, Volume 42, Issue 2, February 2012, Pages 470-475
  Pattu, Varsha; Qu, Bin; Schwarz, Eva C.; Strauß, Bettina; Weins, Lisa; Bhat, Shruthi S.; Halimani, Mahantappa; Marshall, Misty; Rettig, Jens & Hoth, Markus
  
• (2012). SNARE protein expression and localization in human cytotoxic T lymphocytes. Eur J Immunol 42, 470-475
  Pattu, Varsha; Qu, Bin; Schwarz, Eva C.; Strauß, Bettina; Weins, Lisa; Bhat, Shruthi S.; Halimani, Mahantappa; Marshall, Misty; Rettig, Jens & Hoth, Markus
  
• (2012). SNARE protein expression and localization in human cytotoxic T lymphocytes. Eur J Immunol 42, 470-475
  Pattu, Varsha; Qu, Bin; Schwarz, Eva C.; Strauß, Bettina; Weins, Lisa; Bhat, Shruthi S.; Halimani, Mahantappa; Marshall, Misty; Rettig, Jens & Hoth, Markus
  
• (2012). SNARE protein expression and localization in human cytotoxic T lymphocytes. Eur J Immunol 42: 470-475
  Pattu, Varsha; Qu, Bin; Schwarz, Eva C.; Strauß, Bettina; Weins, Lisa; Bhat, Shruthi S.; Halimani, Mahantappa; Marshall, Misty; Rettig, Jens & Hoth, Markus
  
• (2012). Sumoylation regulates Kap114-mediated nuclear transport. EMBO J. 31, 2461-2472
  Rothenbusch, Ute; Sawatzki, Marc; Chang, Yiming; Caesar, Stefanie & Schlenstedt, Gabriel
  
• (2013). Molecular regulation of CRAC channels and their role in lymphocyte function. Cell Mol Life Sci 70, 2637-56
  Shaw, Patrick J.; Qu, Bin; Hoth, Markus & Feske, Stefan
  
• Electrical fusion pore measurements: a high resolution technique to study the molecular mechanism of exocytosis. (2012) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Kamalimoghadam P
  
• Ion currents, action potentials and their modulation by Gαq/11- signalling pathways in the mouse heart. (2012) Medizinische Fakutät, Dissertation Universität des Saarlandes
  Pahlavan S
  
• v-snare-dependent secretion and phospholipid interaction. (2012) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Schwarz Y
  
• (2012). Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br. J. Pharmacol. 168 (8): 1835-1850
  Straub, I.; Mohr, F.; Stab, J.; Konrad, M.; Philipp, Se; Oberwinkler, J. & Schaefer, M.
  
• (2013). A local, periactive zone endocytotic machinery at photoreceptor synapses in close vicinity to synaptic ribbons. The Journal of Neuroscience; 33(25)10278-10300
  Wahl, S.; Katiyar, R. & Schmitz, F.
  
• (2013). Analysis of protein translocation into the endoplasmic reticulum of human cells. Methods Mol Biol 1033 285-299
  Dudek, Johanna; Lang, Sven; Schorr, Stefan; Linxweiler, Johannes; Greiner, Markus & Zimmermann, Richard
  
• (2013). Calcium dysregulation in ventricular myocytes from mice expressing constitutively active Rac1. Cell Calcium 54, 26-36
  Oberhofer, Martin; Tian, Qinghai; Ruppenthal, Sandra; Wegener, Silke; Reil, Jan-Christian; Körbel, Christina; Hammer, Karin; Menger, Michael; Neuberger, Hans-Ruprecht; Kaestner, Lars & Lipp, Peter
  
• (2013). Calcium, cancer and killing: The role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells. Biochim Biophys Acta. 1833: 1603-1611
  Schwarz, Eva C.; Qu, Bin & Hoth, Markus
  
• (2013). Deciphering dead-end docking of large dense core vesicles in bovine chromaffin cells. J Neurosci 33, 17123-17137
  Hugo, Sandra; Dembla, Ekta; Halimani, Mahantappa; Matti, Ulf; Rettig, Jens & Becherer, Ute
  
• (2013). Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes. Traffic
  Dudenhöffer‐Pfeifer, Monika; Schirra, Claudia; Pattu, Varsha; Halimani, Mahantappa; Maier‐Peuschel, Monika; Marshall, Misty R.; Matti, Ulf; Becherer, Ute; Dirks, Jan; Jung, Martin; Lipp, Peter; Hoth, Markus; Sester, Martina; Krause, Elmar & Rettig, Jens
  
• (2013). Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes. Traffic 14, 798-809
  Dudenhöffer‐Pfeifer, Monika; Schirra, Claudia; Pattu, Varsha; Halimani, Mahantappa; Maier‐Peuschel, Monika; Marshall, Misty R.; Matti, Ulf; Becherer, Ute; Dirks, Jan; Jung, Martin; Lipp, Peter; Hoth, Markus; Sester, Martina; Krause, Elmar & Rettig, Jens
  
• (2013). Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo. Mol Pharmacol. 84 (5):736-750
  Straub, Isabelle; Krügel, Ute; Mohr, Florian; Teichert, Jens; Rizun, Oleksandr; Konrad, Maik; Oberwinkler, Johannes & Schaefer, Michael
  
• (2013). In the crosshairs: investigating lytic granules by high-resolution microscopy and electrophysiology. Front Immunol. 4: 411
  Pattu, Varsha; Halimani, Mahantappa; Ming, Min; Schirra, Claudia; Hahn, Ulrike; Bzeih, Hawraa; Chang, Hsin-Fang; Weins, Lisa; Krause, Elmar & Rettig, Jens
  
• (2013). In the crosshairs: Visualizing lytic granules by high resolution microscopy and electrophysiology. Front Immunol 4, 411
  Pattu, Varsha; Halimani, Mahantappa; Ming, Min; Schirra, Claudia; Hahn, Ulrike; Bzeih, Hawraa; Chang, Hsin-Fang; Weins, Lisa; Krause, Elmar & Rettig, Jens
  
• (2013). In the crosshairs: Visualizing lytic granules by high resolution microscopy and electrophysiology. Front Immunol 4, 411
  Pattu, Varsha; Halimani, Mahantappa; Ming, Min; Schirra, Claudia; Hahn, Ulrike; Bzeih, Hawraa; Chang, Hsin-Fang; Weins, Lisa; Krause, Elmar & Rettig, Jens
  
• (2013). Morphologically homogeneous red blld cells present a heterogeneous response to hormonal stimulation. PloS One. 2013;8:e67697
  Wang, Jue; Wagner-Britz, Lisa; Bogdanova, Anna; Ruppenthal, Sandra; Wiesen, Kathrina; Kaiser, Elisabeth; Tian, Qinghai; Krause, Elmar; Bernhardt, Ingolf; Lipp, Peter; Philipp, Stephan E. & Kaestner, Lars
  
• (2013). Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1. J Biol Chem 18:1653-1664
  Kilch, Tatiana; Alansary, Dalia; Peglow, Martin; Dörr, Kathrin; Rychkov, Grigori; Rieger, Heiko; Peinelt, Christine & Niemeyer, Barbara A.
  
• (2013). Profilin1 potentiates apoptosis induced by staurosporine in cancer cells. Curr Mol Med. 13, 417-428
  Yao, W.; Cai, X.; Liu, C.; Qin, Y.; Cheng, H.; Ji, S.; Xu, W.; Wu, C.; Chen, T.; Xu, J.; Long, J.; Fang, Z.; Qu, B.; Hoth, M.; Ni, Q.; Zha, X. & Yu, X.
  
• (2013). Super-resolution microscopy in studying neuroendocrine cell function. Frontiers in neuroscience 7:222
  Bost, Anneka; Pasche, Mathias; Schirra, Claudia & Becherer, Ute
  
• (2013). Synaptobrevin2 is the v-SNARE required for cytotoxic T lymphocyte lytic granule fusion. Nat Commun 4, 1439
  Matti, Ulf; Pattu, Varsha; Halimani, Mahantappa; Schirra, Claudia; Krause, Elmar; Liu, Yuanyuan; Weins, Lisa; Fang Chang, Hsin; Guzman, Raul; Olausson, Jenny; Freichel, Marc; Schmitz, Frank; Pasche, Mathias; Becherer, Ute; Bruns, Dieter & Rettig, Jens
  
• (2013). Synaptobrevin2 is the v-SNARE required for cytotoxic T lymphocyte lytic granule fusion. Nat. Comm. 4: 1439
  Matti, Ulf; Pattu, Varsha; Halimani, Mahantappa; Schirra, Claudia; Krause, Elmar; Liu, Yuanyuan; Weins, Lisa; Fang Chang, Hsin; Guzman, Raul; Olausson, Jenny; Freichel, Marc; Schmitz, Frank; Pasche, Mathias; Becherer, Ute; Bruns, Dieter & Rettig, Jens
  
• (2013). Synaptobrevin2 is the v-SNARE required for cytotoxic T-lymphocyte lytic granule fusion. Nat Commun.
  Matti, Ulf; Pattu, Varsha; Halimani, Mahantappa; Schirra, Claudia; Krause, Elmar; Liu, Yuanyuan; Weins, Lisa; Fang Chang, Hsin; Guzman, Raul; Olausson, Jenny; Freichel, Marc; Schmitz, Frank; Pasche, Mathias; Becherer, Ute; Bruns, Dieter & Rettig, Jens
  
• (2013). Target evaluation of the non-coding csRNAs reveals a link of the two-component regulatory system CiaRH to competence control in Streptococcus pneumoniae R6. Mol Microbiol 89(2):334-49
  Schnorpfeil, Anke; Kranz, Miriam; Kovács, Martá; Kirsch, Christian; Gartmann, Julia; Brunner, Ines; Bittmann, Sabrina & Brückner, Reinhold
  
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