GRK 1326:  Calcium-Signalling and Cellular Nanodomains

• Subject Area: Medicine
• Term: from 2006 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 13307018

• Final Report Year: 2015

Final Report Abstract

Das Graduiertenkolleg 1326 hat sich mit seiner Einrichtung im April 2006 einer konsequenten Verbesserung und Weiterentwicklung der Doktorandenförderung an der Medizinischen Fakultät verpflichtet. Ziel ist es, hochqualifizierte Nachwuchswissenschaftler auf dem zukunftsträchtigen Forschungsfeld intrazellulärer Calcium-Signale auszubilden. Der Forschungsverbund wird von einer Gruppe ausgewiesener WissenschaftlerInnen getragen, die sich methodisch an der rasanten Entwicklung bildgebender Messverfahren, dem zunehmenden Einsatz fluoreszierender Sonden sowie der wachsenden Zahl Ca2+- transportierender Strukturen orientiert und, thematisch fokussiert, die Funktionsanalyse Ca2+- regulierter Signalprozesse vorantreibt. Im Zentrum der Doktorarbeiten stehen Registrierungen des Echtzeitverlaufs zellulärer Ca2+-Signale, ihre räumliche Ausbreitung und Wechselwirkung mit Domänen Ca2+-transportierender und Ca2+-bindender Proteine. Dieses hochaktuelle Forschungsprogramm wird durch ein leistungsorientiertes Studienprogramm ergänzt, das den Kollegiaten praxis-relevante und fächerübergreifende Kenntnisse vermittelt. Die Ausbildung strebt eine breite fachliche Kompetenz der Kollegteilnehmer in molekulargenetischen, biochemischen und zellbiologischen Techniken an. Somit ist es gelungen, die Dichte des Nachwuchses auf diesem Arbeitsgebiet zu steigern, seine Konkurrenzfähigkeit im nationalen und internationalen Vergleich zu stärken, und gleichzeitig die Attraktivität des Standorts mit seinen bestehenden und weiterzuentwickelnden, interdisziplinären Forschungsschwerpunkten zu erhöhen.

Publications

• (2006). Trafficking and assembly of the cold-sensitive TRPM8 channel. J Biol Chem 281, 38396-404
  Erler I, Al-Ansary D, Wissenbach U, Wagner TF, Flockerzi V and Niemeyer BA
  (See online at https://doi.org/10.1074/jbc.M607756200)
• (2008). Multiple RIBEYE–RIBEYE Interactions Create a Dynamic Scaffold for the Formation of Synaptic Ribbons. J Neurosci 28: 7954- 7967
  Magupalli VG, Schwarz K., Alpadi K, Natarajan S, Seigel G.M, Schmitz F
  (See online at https://doi.org/10.1523/JNEUROSCI.1964-08.2008)
• (2009). Analysis of the membrane proteome of canine pancreatic rough microsomes identifies a novel Hsp40, termed ERj7. Proteomics, Proteomics 9, 3463-3473
  Zahedi RP, Völzing C, Schmitt A, Frien M, Jung M, Dudek J, Wortelkamp S, Sickmann A und Zimmermann R
  (See online at https://doi.org/10.1002/pmic.200800722)
• (2009). Isolation and Genetic Manipulation of Adult Cardiac Myocytes for Confocal Imaging. Journal of Visual Experiments
  Kaestner L, Scholz A, Hammer K, Vecerdea A, Ruppenthal S, Lipp P
  (See online at https://dx.doi.org/10.3791/1433)
• (2009). TRCP5 is a Ca 2+-Avtivated channel functionally coupled to Ca 2+ - Selective Ion Channels. J Biol Chem 284, 34423-32
  Gross SA, Guzmán GA, Wissenbach U, Philipp SE, Zhu MX, Bruns D, Cavalié A
  (See online at https://doi.org/10.1074/jbc.M109.018192)
• Charakterisierung von Interaktionen der Hsp-Proteine Sec63p und ERj7p. (2009), Medizinische Fakultät, Dissertation Universität des Saarlandes
  Schmitt A
  (See online at https://dx.doi.org/10.22028/D291-21281)
• (2010). ATP modulates Ca2+ uptake by TRPV6 and is counteracted by isoform-specific phosphorylation. FASEB J 2: 425- 435
  Al-Ansary D, Bogeski I, Disteldorf BM, Becherer U, Niemeyer BA
  (See online at https://doi.org/10.1096/fj.09-141481)
• (2010). Differential Redox Regulation of ORAI Ion Channels: A Mechanism to Tune Cellular Calcium Signaling. Sci Signal 3: ra27
  Bogeski I, Kummerow C, Al-Ansary D, Schwarz EC, Koehler R, Kozai D, Takahashi N, Peinelt C, Griesemer D, Bozem M, Mori Y, Hoth M, Niemeyer BA
  (See online at https://doi.org/10.1126/scisignal.2000672)
• (2010). Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. Journal of Clinical Investigation, 120: 3267-79
  Mathar I, Vennekens R, Meissner M, Kees F, Van der Mieren G, JE Camacho-Londono, Uhl S, Voets T, Hummel B, Herijgers P, Nilius B, Flockerzi V, Schweda F, Freichel M
  (See online at https://doi.org/10.1172/JCI41348)
• (2010). NAD(H)-dependent binding of the neuronal Ca2+-sensor protein GCAP2 to photoreceptor synaptic ribbons. J. Neurosci., 30(19):6559-76
  Venkatesan JK, Natarajan S, Schwarz K, Mayer SI, Alpadi K, Magupalli VG, Sung C-H, Schmitz F
  (See online at https://doi.org/10.1523/JNEUROSCI.3701-09.2010)
• (2010). Novel insights into the mechanisms mediating the local antihypertrophic effects of cardiac atrial natriuretic peptide: role of cGMP-dependent protein kinase and RGS2. Basic Res Cardiol. 105: 583-95
  Klaiber M, Kruse M, Völker K, Schröter J, Feil R, Freichel M, Gerling A, Feil S, Dietrich A, Londoño JE, Baba HA, Abramowitz J, Birnbaumer L, Penninger JM, Pongs O, Kuhn M
  (See online at https://doi.org/10.1007/s00395-010-0098-z)
• (2010). Pharmacology of ORAI channels as a tool to understand their physiological functions. Expert Review of Clinical Pharmacology, 3, 291-303
  Bogeski I, Al-Ansary D, Qu B, Niemeyer BA, Hoth M, Peinelt C
  (See online at https://doi.org/10.1586/ecp.10.23)
• (2010). Pharmacology of ORAI channels as a tool to understand their physiological functions. Expert Reviews of Clinical Pharmacology 3: 291-303
  Bogeski I, Al-Ansary D, Qu B, Niemeyer BA, Hoth M, Peinelt C
  (See online at https://doi.org/10.1586/ecp.10.23)
• (2010). Properties of the intracellular transient receptor potential (TRP) channel in yeast, Yvc1. FEBS Lett. 584, 2028-2032
  Chang Y, Schlenstedt G, Flockerzi V and Beck A
  (See online at https://doi.org/10.1016/j.febslet.2009.12.035)
• (2010). Remodelling of Ca2+ handling organelles in adult rat ventricular myocytes during longterm culture. JMCC 49: 427-437
  Hammer K, Ruppenthal S, Viero C, Scholz A, Edelmann L, Kaestner L, Lipp P
  (See online at https://doi.org/10.1007/978-3-642-34617-0_19)
• (2010). TRPM channels mediate zinc homeostasis and cellular growth during Drosophila larval development. Cell Metab. 12(4):386-97
  Georgiev P, Okkenhaug H, Drews A, Wright D, Lambert S, Flick M, Carta V, Martel C, Oberwinkler J, Raghu P
  (See online at https://doi.org/10.1016/j.cmet.2010.08.012)
• (2010). TRPM3 channels provide a regulated influx pathway for zinc in pancreatic beta cells. Pflugers Arch. 460 (4): 755-765
  Wagner TF, Drews A, Loch S, Mohr F, Philipp SE, Lambert S, Oberwinkler J
  (See online at https://doi.org/10.1007/s00424-010-0838-9)
• (2010). TRPM3 channels provide a regulated influx pathway for zinc in pancreatic beta cells. Pflugers Arch. 460(4):755-65
  Wagner TF, Drews A, Loch S, Mohr F, Philipp SE, Lambert S, Oberwinkler J
  (See online at https://doi.org/10.1007/s00424-010-0838-9)
• Characterization of the Vacuolar Ion Channel Yvc1 in Saccharomyces cerevisiae. (2010) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Chang Y
  
• High Resolution 3D-Imaging of the Physiology and Morphology of Isolated Adult Cardiac Myocytes from Rat and Mice. (2010) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Hammer K
  (See online at https://dx.doi.org/10.22028/D291-21192)
• Increased catecholamine secretion contributes to hypertension in TRPM4-deficient mice. Journal of Clinical Investigation, 120: 3267-79
  Mathar I, Vennekens R, Meissner M, Kees F, Van der Mieren G, JE Camacho-Londono, Uh, S, Voets T, Hummel B, Herijgers P, Nilius B, Flockerzi V, Schweda F, Freichel M
  (See online at https://doi.org/10.1172/JCI41348)
• Regulatory mechanisms of the calcium selective ion channels TRPV6 and ORAI1. (2010) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Al-Ansary A
  
• Syntaxin7 is required for lytic granule release from cytotoxic T- lymphocytes. (2010) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Pattu V
  (See online at https://dx.doi.org/10.22028/D291-21268)
• Vti1b-dependent interaction between lytic granules and recycling TCR compartments is required for efficient function of cytotoxic T lymphocytes. (2010) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Qu B
  (See online at https://dx.doi.org/10.22028/D291-21301)
• (2011). Calcium microdomains at the immunological synapse: how ORAI channels, mitochondria and calcium pumps generate localcalcium signals for T-cell activation. EMBO J 2011; 30(19):3895-912
  Quintana A, Pasche M, Junker C, Al-Ansary D, Nuñez L, Villalobos C, Niemeyer BA, Becherer U, Rettig J & Hoth M
  (See online at https://doi.org/10.1038/emboj.2011.289)
• (2011). Docking of Lytic Granules at the Immunological Synapse in Human CTL Requires Vti1b-Dependent Pairing with CD3 Endosomes. J Immunol 186 (12): 6894-6904
  Qu B, Pattu V, Junker C, Schwarz EC, Bhat SS, Kummerow C, Marshall M, Matti U, Neumann F, Pfreundschuh M, Becherer U, Rieger H, Rettig J, Hoth M
  (See online at https://doi.org/10.4049/jimmunol.1003471)
• (2011). Docking of lytic granules at the immunological synapse in human CTL requires Vti1b-dependent pairing with TCR endosomes. J Immunol 186, 6894-6904
  Qu B, Pattu V, Junker C, Schwarz EC, Marshall M, Matti U, Becherer U, Bhat SS, Kummerow C, Neumann F, Pfreundschuh M, Rieger H, Rettig J, Hoth M
  (See online at https://doi.org/10.4049/jimmunol.100347)
• (2011). Docking of lytic granules at the immunological synapse in human CTL requires Vti1b-dependent pairing with TCR endosomes. J Immunol 186, 6894-6904
  Qu B, Pattu V, Junker C, Schwarz EC, Marshall M, Matti U, Becherer U, Bhat S, Kummerow K, Neumann F, Pfreundschuh M, Rieger H, Rettig J, Hoth M
  (See online at https://doi.org/10.4049/jimmunol.1003471)
• (2011). Loss-of-function mutations in sodium channel Nav1.7 cause anosmia.Nature 472, 186 – 190
  Weiss J, Pyrski M, Jacobi E, Bufe B, Willnecker V, Schick B, Zizzari P, Gossage SJ, Greer CA, Leinders-Zufall T, Woods G, Wood JN, Zufall F
  (See online at https://doi.org/10.1038/nature09975)
• (2011). Moderate Calcium Channel Dysfunction in Adult Mice with Inducible Cardiomyocyte-specific Excision of the cacnb2 Gene. J Biol Chem. 286: 15875-82
  Meissner M, Weissgerber P, Londoño JE, Prenen J, Link S, Ruppenthal S, Molkentin JD, Lipp P, Nilius B, Freichel M, Flockerzi V
  (See online at https://doi.org/10.1074/jbc.M111.227819)
• (2011). ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance. Cell Calcium
  Qu B, Al-Ansary D, Kummerow C, Hoth M, Schwarz EC
  (See online at https://doi.org/10.1016/j.ceca.2011.05.015)
• (2011). ORAI-mediated calcium influx in T cell proliferation, apoptosis and tolerance. Cell Calcium 50: 261-269
  Qu B, Al-Ansary D, Kummerow C, Hoth M, Schwarz EC
  (See online at https://doi.org/10.1016/j.ceca.2011.05.015)
• (2011). Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes. Traffic 12 (7): 890-901
  Pattu V, Qu B, Marshall M, Becherer U, Junker C, Matti U, Schwarz EC, Krause E, Hoth M, Rettig J
  (See online at https://doi.org/10.1111/j.1600-0854.2011.01193.x)
• (2011). Syntaxin7 is required for lytic granule release from cytotoxic T lymphocytes. Traffic 12, 890-912
  Pattu V, Qu B, Marshall M, Becherer U, Junker C, Schwarz EC, Matti U, Schwarz EC, Krause E, Hoth M, Rettig J
  (See online at https://doi.org/10.1111/j.1600-0854.2011.01193.x)
• (2011). The Synaptic Ribbon Is a Site of Phosphatidic Acid Generation in Ribbon Synapses, J. Neurosci.; 31(44): 15996-16011
  Schwarz K, Natarajan S, Kassas N, Vitale N, Schmitz F
  (See online at https://doi.org/10.1523/JNEUROSCI.2965-11.2011)
• (2011). Transient receptor potential melastatin 1 (TRPM1) is an ionconducting plasma membrane channel inhibited by zinc ions. J Biol Chem. 286(14):12221-33
  Lambert S, Drews A, Rizun O, Wagner TF, Lis A, Mannebach S, Plant S, Portz M, Meissner M, Philipp SE, Oberwinkler J
  (See online at https://doi.org/10.1074/jbc.M110.202945)
• A Biopolar Cell Culture of the Mouse Retina to Study Ribbon Synapses. (2011) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Natarajan S
  
• Elektrophysiologische Charakterisierung der murinen Ionenkanäle TRPM1 und TRPM3 und des TRPM Kanals von Drosophila melanogaster“, (2011) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Drews A
  (See online at https://dx.doi.org/10.22028/D291-21412)
• Role of TRPC-channels in cardiac hypertrophy and platelet aggregation: Analysis of TRPC-deficient mice. (2011) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Camacho-Londoňo JE
  
• (2010). SNARE force synchronizes synaptic vesicle fusion and controls the kinetics of quantal synaptic transmission. J Neurosci 30, 10272- 81
  Guzman RE, Schwarz YN, Rettig J and Bruns D
  (See online at https://doi.org/10.1523/JNEUROSCI.1551-10.2010)
• (2012). Alternative Splicing of a Protein Domain Indispensable for Function of Transient Receptor Potential Melastatin 3 (TRPM3) Ion Channels. J Biol Chem 287, 36663-36672
  Fruhwald J, Camacho Londono J, Dembla S, Mannebach S, Lis A, Drews A, Wissenbach U, Oberwinkler J and Philipp SE
  (See online at https://doi.org/10.1074/jbc.M112.396663)
• (2012). Alternative splicing of a protein domain indispensable for function of transient receptor potential melastatin 3 (TRPM3) ion channels. J Biol Chem.
  Frühwald J1, Camacho Londoño J1, Dembla S, Mannebach S, Lis A, Drews A, Wissenbach U, Oberwinkler J, Philipp SE
  (See online at https://doi.org/10.1074/jbc.M112.396663)
• (2012). Alternative splicing of a protein domain indispensable for function of transient receptor potential melastatin 3 (TRPM3) ion channels. J Biol Chem. 287(44):36663-72
  Frühwald J, Camacho Londoño J, Dembla S, Mannebach S, Lis A, Drews A, Wissenbach U, Oberwinkler J, Philipp SE
  (See online at https://doi.org/10.1074/jbc.M112.396663)
• (2012). BiP-mediated closing of the Sec61 channel limits Ca2+ leakage from the ER. EMBO J 31 3282-3296
  Schäuble N, Lang S, Jung M, Cappel S, Schorr S, Ulucan O, Linxweiler J, Dudek J, Blum R, Helms V, Paton AW, Paton JC, Cavalie A, Zimmermann R
  (See online at https://doi.org/10.1038/emboj.2012.189)
• (2012). Citrus fruit and fabacea secondary metabolites potently and selectively block TRPM3. Br. J. Pharmacol. 168 (8): 1835-1850
  Straub I, Mohr F, Stab J, Konrad M, Philipp SE, Oberwinkler J, Schaefer M
  (See online at https://doi.org/10.1111/bph.12076)
• (2012). Different effects of Sec61alpha, Sec62 and Sec63 depletion on transport of polypeptides into the endoplasmic reticulum of mammalian cells. J Cell Sci 125 1958-1969
  Lang S, Benedix J, Fedeles SV, Schorr S, Schirra C, Schäuble N, Jalal C, Greiner M, Hassdenteufel S, Tatzelt J. Kreutzer B, Edelmann L, Krause E, Rettig J, Somlo S, Zimmermann R, Dudek J
  (See online at https://doi.org/10.1242/jcs.096727)
• (2012). EF handmediated Ca and cGMP signaling in photoreceptor synaptic terminals, Front Mol Neurosci. 2012;5:26. Epub
  Schmitz F, Natarajan S, Venkatesan JK, Wahl S, Schwarz K, Grabner CP
  (See online at https://doi.org/10.3389/fnmol.2012.00026)
• (2012). Functional and morphological preservation of adult ventricular myocytes in culture by sub-micromolar cytochalasin D supplement. J Mol Cell Cardiol. 52(1):113-24
  Tian Q, Pahlavan S, Oleinikow K, Jung J, Ruppenthal S, Scholz A, Schumann C, Kraegeloh A, Oberhofer M, Lipp P, Kaestner L
  (See online at https://doi.org/10.1016/j.yjmcc.2011.09.001)
• (2012). Gαq and Gα11 contribute to the maintenance of cellular electrophysiology and Ca2+ handling in ventricular cardiomyocytes. Cardiovasc Res. 95(1):48-58
  Pahlavan S, Oberhofer M, Sauer B, Ruppenthal S, Tian Q, Scholz A, Kaestner L, Lipp, P
  (See online at https://doi.org/10.1093/cvr/cvs162)
• (2012). Membrane-proximal tryptophans of synaptobrevinII stabilize priming of secretory vesicles. J. Neurosci. 32(45),15983-97
  Borisovska M, Schwarz Y, Dhara M, Yarzagaray A, Hugo S, Narzi D, Siu S, Kesavan J, Mohrmann R, Böckmann R, Bruns D
  (See online at https://doi.org/10.1523/JNEUROSCI.6282-11.2012)
• (2012). Membrane-proximal tryptophans of synaptobrevinII stabilize priming of secretory vesicles. J. Neurosci. 32(45),15983-97
  Borisovska M, Schwarz Y, Dhara M, Yarzagaray A, Hugo S, Narzi D, Siu S, Kesavan J, Mohrmann R, Böckmann R, Bruns D
  (See online at https://doi.org/10.1523/JNEUROSCI.6282-11.2012)
• (2012). Mutation of the CaV1.2 IQ Motif to CaV1.2 EQ induces dilated Cardiomyopathy and Death. J Biol Chem. 287(27):22616-25
  Blaich A, Pahlavan S, Tian Q, Oberhofer M, Poomvanicha M, Lenhardt P, Domes K, Wegener JW, Moosmang S, Ruppenthal S, Scholz A, Lipp P, Hofmann F
  (See online at https://doi.org/10.1074/jbc.M112.357921)
• (2012). SNARE protein expression and localization in human cytotoxic lymphocytes. Eur J Immunol, Volume 42, Issue 2, February 2012, Pages 470-475
  Pattu V, Qu B, Schwarz EC, Strauss B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M
  (See online at https://doi.org/10.1002/eji.201141915)
• (2012). SNARE protein expression and localization in human cytotoxic T lymphocytes. Eur J Immunol 42, 470-475
  Pattu V, Qu B, Schwarz EC, Strauss B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M
  (See online at https://doi.org/10.1002/eji.201141915)
• (2012). SNARE protein expression and localization in human cytotoxic T lymphocytes. Eur J Immunol 42, 470-475
  Pattu V, Qu B, Schwarz EC, Strauss B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J, Hoth M
  (See online at https://doi.org/10.1002/eji.201141915)
• (2012). SNARE protein expression and localization in human cytotoxic T lymphocytes. Eur J Immunol 42: 470-475
  Pattu V, Qu B, Schwarz EC, Strauss B, Weins L, Bhat SS, Halimani M, Marshall M, Rettig J and Hoth M
  (See online at https://doi.org/10.1002/eji.201141915)
• (2012). Sumoylation regulates Kap114-mediated nuclear transport. EMBO J. 31, 2461-2472
  Rothenbusch U, Sawatzki M, Chang Y, Caesar S and Schlenstedt G
  (See online at https://doi.org/10.1038/emboj.2012.102)
• Electrical fusion pore measurements: a high resolution technique to study the molecular mechanism of exocytosis. (2012) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Kamalimoghadam P
  (See online at https://dx.doi.org/10.22028/D291-21528)
• Ion currents, action potentials and their modulation by Gαq/11- signalling pathways in the mouse heart. (2012) Medizinische Fakutät, Dissertation Universität des Saarlandes
  Pahlavan S
  (See online at https://dx.doi.org/10.22028/D291-21641)
• v-snare-dependent secretion and phospholipid interaction. (2012) Medizinische Fakultät, Dissertation Universität des Saarlandes
  Schwarz Y
  
• (2013). A local, periactive zone endocytotic machinery at photoreceptor synapses in close vicinity to synaptic ribbons. The Journal of Neuroscience; 33(25)10278-10300
  Wahl S, Katiyar R, Schmitz F
  (See online at https://doi.org/10.1523/JNEUROSCI.5048-12.2013)
• (2013). Analysis of protein translocation into the endoplasmic reticulum of human cells. Methods Mol Biol 1033 285-299
  Dudek J, Lang S, Schorr S, Linxweiler J, Greiner M, Zimmermann R
  (See online at https://doi.org/10.1007/978-1-62703-487-6_18)
• (2013). Calcium dysregulation in ventricular myocytes from mice expressing constitutively active Rac1. Cell Calcium 54, 26-36
  Oberhofer M, Tian Q, Ruppenthal S, Wegener S, Reil JC, Körbel C, Hammer K, Menger M, Neuberger HR, Kaestner L, Lipp P
  (See online at https://doi.org/10.1016/j.ceca.2013.03.006)
• (2013). Calcium, cancer and killing: The role of calcium in killing cancer cells by cytotoxic T lymphocytes and natural killer cells. Biochim Biophys Acta. 1833: 1603-1611
  Schwarz EC, Qu B and Hoth M
  (See online at https://doi.org/10.1016/j.bbamcr.2012.11.016)
• (2013). Deciphering dead-end docking of large dense core vesicles in bovine chromaffin cells. J Neurosci 33, 17123-17137
  Hugo S, Dembla E, Halimani M, Matti U, Rettig J, Becherer U
  (See online at https://doi.org/10.1523/JNEUROSCI.1589-13.2013)
• (2013). Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes. Traffic
  Dudenhöffer-Pfeifer M, Schirra C, Pattu V, Halimani M, Maier-Peuschel M, Marshall MR, Matti U, Becherer U, Dirks J, Jung M, Lipp P, Hoth M, Sester M, Krause E, Rettig J
  (See online at https://doi.org/10.1111/tra.12074)
• (2013). Different Munc13 isoforms function as priming factors in lytic granule release from murine cytotoxic T lymphocytes. Traffic 14, 798-809
  Dudenhöffer-Pfeifer M, Schirra C, Pattu V, Halimani M, Maier-Peuschel M, Marshall MR, Matti U, Becherer U, Dirks J, Jung M, Lipp P, Hoth M, Sester M, Krause E, Rettig J
  (See online at https://doi.org/10.1111/tra.12074)
• (2013). Flavanones that selectively inhibit TRPM3 attenuate thermal nociception in vivo. Mol Pharmacol. 84 (5):736-750
  Straub I, Krügel U, Mohr F, Teichert J, Rizun O, Konrad M, Oberwinkler J, Schaefer M
  (See online at https://doi.org/10.1124/mol.113.086843)
• (2013). In the crosshairs: investigating lytic granules by high-resolution microscopy and electrophysiology. Front Immunol. 4: 411
  Pattu V, Halimani M, Ming M, Schirra C, Hahn U, Bzeih H, Chang HF, Weins L, Krause E, Rettig J
  (See online at https://doi.org/10.3389/fimmu.2013.00411)
• (2013). In the crosshairs: Visualizing lytic granules by high resolution microscopy and electrophysiology. Front Immunol 4, 411
  Pattu V, Halimani M, Ming M, Schirra C, Hahn U, Bzeih H, Chang HF, Weins L, Krause E, Rettig J
  (See online at https://doi.org/10.3389/fimmu.2013.00411)
• (2013). In the crosshairs: Visualizing lytic granules by high resolution microscopy and electrophysiology. Front Immunol 4, 411
  Pattu V, Halimani M, Ming M, Schirra C, Hahn U, Bzeih H, Chang HF, Weins L, Krause E, Rettig J
  (See online at https://doi.org/10.3389/fimmu.2013.00411)
• (2013). Molecular regulation of CRAC channels and their role in lymphocyte function. Cell Mol Life Sci 70, 2637-56
  Shaw PJ, Qu B, Hoth M, Feske S
  (See online at https://doi.org/10.1007/s00018-012-1175-2)
• (2013). Morphologically homogeneous red blld cells present a heterogeneous response to hormonal stimulation. PloS One. 2013;8:e67697
  Wang J, Wagner-Britz L, Bogdanova A, Ruppenthal S, Wiesen K, Kaiser E, Tian Q, Krause E, Bernhardt I, Lipp P, Philipp SE and Kaestner L
  (See online at https://doi.org/10.1371/journal.pone.0067697)
• (2013). Mutations of the Ca2+-sensing stromal interaction molecule STIM1 regulate Ca2+ influx by altered oligomerization of STIM1 and by destabilization of the Ca2+ channel Orai1. J Biol Chem 18:1653-1664
  Kilch T, Alansary D, Peglow M, Dörr K, Rychkov G, Rieger H, Peinelt C, Niemeyer BA
  (See online at https://doi.org/10.1074/jbc.M112.417246)
• (2013). Profilin1 potentiates apoptosis induced by staurosporine in cancer cells. Curr Mol Med. 13, 417-428
  Yao W, Cai X, Liu C, Qin Y, Cheng H, Ji S, Xu W, Wu C, Chen T, Xu J, Long J, Fang Z, Qu B, Hoth M, Ni Q, Zha X, Yu X
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