Mitochondrial calcium homeostasis as a key regulator of the calcium dependent immune response

• Antragsteller: Dr. Ariel Quintana-González
• Fachliche Zuordnung: Immunologie
• Förderung: Förderung von 2009 bis 2011
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 136006733

• Erstellungsjahr: 2012

Zusammenfassung der Projektergebnisse

In summary, although their function as membrane barriers and/or organizers has been recognized previously, this is the first time that Septin proteins have been implicated in the regulation of Ca2+ entry in mammalian cells. Interestingly, a mitochondrial-associated form of Sept4 has been recently reported to be involved in the regulation of apoptosis and tumourigenesis in stem cells. Altogether, these results illustrate the potential impact and contribution of our screen to the cell biology.