Mitochondrial calcium homeostasis as a key regulator of the calcium dependent immune response

• Applicant: Dr. Ariel Quintana-González
• Subject Area: Immunology
• Term: from 2009 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 136006733

• Final Report Year: 2012

Final Report Abstract

In summary, although their function as membrane barriers and/or organizers has been recognized previously, this is the first time that Septin proteins have been implicated in the regulation of Ca2+ entry in mammalian cells. Interestingly, a mitochondrial-associated form of Sept4 has been recently reported to be involved in the regulation of apoptosis and tumourigenesis in stem cells. Altogether, these results illustrate the potential impact and contribution of our screen to the cell biology.