Pathway-dependent plasticity at hippocampal CA1 pyramidal cells
Zusammenfassung der Projektergebnisse
Hebbian synaptic plasticity is associative and usually pathway-specific, and is therefore assumed to support learning and memory storage better than nonassociative global plasticity. The latter can represent neuron-wide changes in synaptic efficacy and intrinsic excitability as confirmed here for CA1 pyramidal cells. Global plasticity was not observed for CA3 pyramidal neurons, which express plasticity differently from CA1 pyramidal neurons. However, neuronal network models often consider interactions of pathway-specific and global plasticity. These interactions are considered to increase the repertoire of plasticity mechanisms and thereby the possibilities of learning and memory storage mechanisms. Our finding that synaptic activity in distinct CA1 pathways is capable of asymmetrically regulating global plasticity highlights that individual synapses are not regulated in isolation. The interplay between OR and RAD may reflect the interaction of contextual and spatial representations important for episodic memory.
Projektbezogene Publikationen (Auswahl)
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(2012) D4 dopamine receptors modulate NR2B NMDA receptors and LTP in stratum oriens of hippocampal CA1. Cerebral Cortex 22, 1786-1798
Marina Herwerth, Vidar Jensen, Martin Novak, Witold Konopka, Oivind Hvalby and Georg Köhr
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(2016) D4 receptor activation differentially modulates hippocampal basal and apical dendritic synapses in freely moving mice. Cerebral Cortex 26, 647-655
Shi-Bin Li, Dan Du, Mazahir T. Hasan and Georg Köhr
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(2017 Dec 6) Interplay between global and pathwayspecific synaptic plasticity in CA1 pyramidal cells. Scientific Reports 1-12
Sven Berberich, Jörg Pohle, Marie Pollard, Janet Barroso-Flores and Georg Köhr
