Detailseite
Projekt
Der Einfluss des Hepatitis C Virus auf humane B-Zelen und die Rolle von HCV auf B-Zell-lymphoproliferative Erkrankungen (A02)
Fachliche Zuordnung
Virologie
Förderung
Förderung von 2009 bis 2017
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 47100475
As a first aim, we want to characterize the occurrence and characteristics of monoclonal B cell expansions in HCV patients (monoclonal B cell lymphocytosis (MBL) and mixed cryoblobulinema) without lymphomas. This includes determination of the specific B cell subsets that give rise to MBL and determination by deep sequencing of isolated clones whether they already carry genetic lesions and hence represent pre-malignant B cells. Secondly, we aim to determine the landscape of somatic mutations in HCV-associated B cell lymphomas to clarify whether such tumors have a specific, HCV-related pathogenesis. Thirdly, we will study the direct influences of HCV on B cells in culture in terms of signaling pathway activations and altered gene expression to reveal the mechanisms by which HCV affects B cell fate and physiology.
DFG-Verfahren
Transregios
Antragstellende Institution
Universität Duisburg-Essen
Teilprojektleiter
Professor Dr. Jan Dürig; Professor Dr. Ralf Küppers
