Detailseite
Projekt
Enhancement of HIV Env specific antibody responses by intrastructural help from heterologous T helper cells (C02)
Fachliche Zuordnung
Virologie
Förderung
Förderung von 2009 bis 2015
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 47100475
Gag-specific T-helper cells increase the Env antibody response in mice after booster immunizations with virus-like particles (VLPs) containing Gag and Env by the intrastructural help mechanism. The aim of the current project is to exploit this intrastructural help to modulate the antibody response to HIV Env by heterologous T helper cells. Mice will be immunized against heterologous antigens prior to booster immunizations with VLPs containing the heterologous antigens inside. By using different modes of priming against the heterologous antigens, we aim to modulate the humoral immune response to the HIV Env with a particular focus on inducing mucosal immune responses.
DFG-Verfahren
Transregios
Antragstellende Institution
Universität Duisburg-Essen
Mitantragstellende Institution
Ruhr-Universität Bochum
Teilprojektleiter
Professor Dr. Klaus Überla, bis 1/2015
