Perfusionsdarstellung abdomineller Organe zur Tumordetektion und -charakterisierung mittels dynamischerr Volumen-Computertomographie
Zusammenfassung der Projektergebnisse
Description of the most important scientific achievements of the research projects: - CT accurately measures true flow. CT perfusion may be clinically applied. - Longer venous injection bolus in CT perfusion using maximum slope method reflects true flow within an acceptable error margin. - Intravenous contrast bolus length should remain unaltered in serial perfusion CTs to avoid misinterpretation. Patlak analysis should start after recirculation (approx. 30 s) and should not include measurements later than 78 s post intravenous contrast material injection. - Low-dose scanning technique has only marginal influence on CT perfusion measurements and can be used in order to reduce radiation dose in patients undergoing perfusion CT. - Iterative reconstruction leads to significant reduction in perfusion pixel noise while maintaining regional perfusion values, therefore potentially improving reproducibility and allowing for radiation dose reduction during data acquisition. Shallow breathing during dynamic volume CT scanning reduces the overall demand for motion correction and thus may be beneficial in perfusion imaging. - Combining perfusion and diagnostic CT in one examination allows for longitudinal assessment of HCC and liver parenchyma perfusion, while maintaining diagnostic image quality.
Projektbezogene Publikationen (Auswahl)
- 320-Schicht dynamisches Volumen CT zur Analyse schwerer akuter Pankreatitis in der initalen Phase. Annual Assembly of the German Radiological Society 2010
Kandel S, Kloeters C, Meyer H, Hein P, Rogalla P
- 320-slice Dynamic Volume CT to Analyse early stages of Severe Acute Pancreatitis. ECR annual meeting 2010
Kandel S, Kloeters C, Meyer H, Rogalla P
- Comparison of free breathing versus breathhold in perfusion imaging using dynamic volume CT. ECR annual meeting 2010
Kandel S, Kloeters C, Meyer H, Rogalla P
- Influence of Free Breathing on Motion Correction in Abdominal Perfusion Imaging Using Dynamic Volume CT. RSNA annual meeting 2010
Kandel S, Meyer H, Rogalla P
- Iterative Reconstruction Using 320-Slice Computed Tomography in Abdominal Perfusion Imaging: Initial Results. RSNA annual meeting 2010
Rogalla P, Kandel S, Meyer H
- Nierenzellkarzinom in der Perfusions-CT: erste klinische Erfahrungen. Annual Assembly of the German Radiological Society 2010
Kandel S, Kloeters C, Meyer H, Hein P, Rogalla P
- Principles in CT perfusion imaging of the kidneys: Acquisition protocols and post-processing methods. ECR annual meeting 2010
Kloeters C, Kandel S, Rogalla P
- Vergleich von Untersuchungsprotokollen in der Perfusionsbildgebung mittels dynamischen Volumen CT. Annual Assembly of the German Radiological Society 2010
Kandel S, Meyer H, Kloeters C, Rogalla P
- Verändert iterative Rekonstruktion die Perfusionsbildgebung im CT? Annual Assembly of the German Radiological Society 2010
Rogalla P, Meyer H, Hein P, Lembcke A, Kandel S
- Does Low-Dose Imaging Technique Compromise CT Perfusion Results? RSNA annual meeting 2011
Rogalla P, Tran P, Meyer H, Kandel S
- Dynamic volume CT with iterative reconstruction in abdominal perfusion imaging: Initial results. ECR annual meeting 2011
Rogalla P, Meyer H, Kandel S
- How Influential Is the Length of Contrast Material Bolus in Perfusion CT? Evaluation in a Swine Model. RSNA annual meeting 2011
Kandel S, Meyer H, Boehnert M, Mehrez H, Rogalla P
- Microbubble ultrasound (DCE-US) compared to DCE-MRI and DCE-CT for the assessment of vascular response to sunitinib in renal cell carcinoma (RCC). ASCO annual meeting 2011
Bjarnason GA, Williams R, Hudson JM, Bailey C, Lee CR, Lloyd BA, Kandel S, Ebos JM, Kiss A, Kerbel RS, Milot L, Atri M, Stanisz GJ, Burns PN
- Optimal Timing for Patlak Perfusion Analysis. RSNA annual meeting 2011
Rogalla P, Hoppel B, Mehrez H, Paul N, Meyer H, Kandel S
- Validation of Volume CT Perfusion Measurements in Swine Kidney. RSNA annual meeting 2011
Meyer H, Kandel S, Tran L, Boehnert M, Rogalla P
- Comparison of free Breathing versus Breath-hold in Perfusion Imaging Using Dynamic Volume CT. Insights Imaging 2012
Kandel S, Meyer H, Hein P, Lembcke A, Rueckert JC, Rogalla P
(Siehe online unter https://doi.org/10.1007/s13244-012-0169-9) - Does image registration influence tumour perfusion values? ESGAR annual meeting 2012
Kandel S, Meyer H, Rogalla P
