Perfusionsdarstellung abdomineller Organe zur Tumordetektion und -charakterisierung mittels dynamischerr Volumen-Computertomographie

• Applicant: Dr. Sonja Kandel
• Subject Area: Nuclear Medicine, Radiotherapy, Radiobiology
• Term: from 2009 to 2011
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 157548294

• Final Report Year: 2012

Final Report Abstract

Description of the most important scientific achievements of the research projects: - CT accurately measures true flow. CT perfusion may be clinically applied. - Longer venous injection bolus in CT perfusion using maximum slope method reflects true flow within an acceptable error margin. - Intravenous contrast bolus length should remain unaltered in serial perfusion CTs to avoid misinterpretation. Patlak analysis should start after recirculation (approx. 30 s) and should not include measurements later than 78 s post intravenous contrast material injection. - Low-dose scanning technique has only marginal influence on CT perfusion measurements and can be used in order to reduce radiation dose in patients undergoing perfusion CT. - Iterative reconstruction leads to significant reduction in perfusion pixel noise while maintaining regional perfusion values, therefore potentially improving reproducibility and allowing for radiation dose reduction during data acquisition. Shallow breathing during dynamic volume CT scanning reduces the overall demand for motion correction and thus may be beneficial in perfusion imaging. - Combining perfusion and diagnostic CT in one examination allows for longitudinal assessment of HCC and liver parenchyma perfusion, while maintaining diagnostic image quality.

Publications

• 320-Schicht dynamisches Volumen CT zur Analyse schwerer akuter Pankreatitis in der initalen Phase. Annual Assembly of the German Radiological Society 2010
  Kandel S, Kloeters C, Meyer H, Hein P, Rogalla P
  
• 320-slice Dynamic Volume CT to Analyse early stages of Severe Acute Pancreatitis. ECR annual meeting 2010
  Kandel S, Kloeters C, Meyer H, Rogalla P
  
• Comparison of free breathing versus breathhold in perfusion imaging using dynamic volume CT. ECR annual meeting 2010
  Kandel S, Kloeters C, Meyer H, Rogalla P
  
• Influence of Free Breathing on Motion Correction in Abdominal Perfusion Imaging Using Dynamic Volume CT. RSNA annual meeting 2010
  Kandel S, Meyer H, Rogalla P
  
• Iterative Reconstruction Using 320-Slice Computed Tomography in Abdominal Perfusion Imaging: Initial Results. RSNA annual meeting 2010
  Rogalla P, Kandel S, Meyer H
  
• Nierenzellkarzinom in der Perfusions-CT: erste klinische Erfahrungen. Annual Assembly of the German Radiological Society 2010
  Kandel S, Kloeters C, Meyer H, Hein P, Rogalla P
  
• Principles in CT perfusion imaging of the kidneys: Acquisition protocols and post-processing methods. ECR annual meeting 2010
  Kloeters C, Kandel S, Rogalla P
  
• Vergleich von Untersuchungsprotokollen in der Perfusionsbildgebung mittels dynamischen Volumen CT. Annual Assembly of the German Radiological Society 2010
  Kandel S, Meyer H, Kloeters C, Rogalla P
  
• Verändert iterative Rekonstruktion die Perfusionsbildgebung im CT? Annual Assembly of the German Radiological Society 2010
  Rogalla P, Meyer H, Hein P, Lembcke A, Kandel S
  
• Does Low-Dose Imaging Technique Compromise CT Perfusion Results? RSNA annual meeting 2011
  Rogalla P, Tran P, Meyer H, Kandel S
  
• Dynamic volume CT with iterative reconstruction in abdominal perfusion imaging: Initial results. ECR annual meeting 2011
  Rogalla P, Meyer H, Kandel S
  
• How Influential Is the Length of Contrast Material Bolus in Perfusion CT? Evaluation in a Swine Model. RSNA annual meeting 2011
  Kandel S, Meyer H, Boehnert M, Mehrez H, Rogalla P
  
• Microbubble ultrasound (DCE-US) compared to DCE-MRI and DCE-CT for the assessment of vascular response to sunitinib in renal cell carcinoma (RCC). ASCO annual meeting 2011
  Bjarnason GA, Williams R, Hudson JM, Bailey C, Lee CR, Lloyd BA, Kandel S, Ebos JM, Kiss A, Kerbel RS, Milot L, Atri M, Stanisz GJ, Burns PN
  
• Optimal Timing for Patlak Perfusion Analysis. RSNA annual meeting 2011
  Rogalla P, Hoppel B, Mehrez H, Paul N, Meyer H, Kandel S
  
• Validation of Volume CT Perfusion Measurements in Swine Kidney. RSNA annual meeting 2011
  Meyer H, Kandel S, Tran L, Boehnert M, Rogalla P
  
• Comparison of free Breathing versus Breath-hold in Perfusion Imaging Using Dynamic Volume CT. Insights Imaging 2012
  Kandel S, Meyer H, Hein P, Lembcke A, Rueckert JC, Rogalla P
  (See online at https://doi.org/10.1007/s13244-012-0169-9)
• Does image registration influence tumour perfusion values? ESGAR annual meeting 2012
  Kandel S, Meyer H, Rogalla P