Project Details
Projekt
(Dys)-regulation of the cellular HCV-specific immune response (A06)
Subject Area
Gastroenterology
Term
from 2010 to 2021
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 80750187
In acute HCV infection CD4 + T cells lose their functionality and the infection chronically in a plurality of patients, under the influence of co-inhibitor molecules. phenotypic and functional examination of intrahepatic and peripheral T cell populations will be at various stages of HCV infection. For this purpose we will also use the antigen MHC class I + II tetramer technology to to perform single-cell transcriptional analysis on different peripheral and intrahepatic antigen-specific T cell populations with different clinical courses. We plan an integrated analysis with other arms (Tregs, Tr1, Th17, NK cells, MAIT cells) of the immune system.
DFG Programme
Collaborative Research Centres
Applicant Institution
Universität Hamburg
Project Head
Professor Dr. Julian Schulze zur Wiesch
