Expression and function of the non-neuronal cholinergic system in murine embryonic stem cells

• Applicant: Professor Charles James Kirkpatrick, Ph.D.
• Subject Area: Pathology
• Term: from 2010 to 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 164641675

• Final Report Year: 2016

No abstract available

Publications

• Expression of muscarinic receptors on the murine embryonic stem cell line CGR8. Autonomic Neuroscience: Basic and Clinical 177, 61, 2013
  Wessler, I.; Kaltwasser, S.; Tsaryk, R.; Michel-Schmidt, R. & Kirkpatrick, C.J.
  
• Tumor-promoting activities of nicotine not addressed. Dtsch Arztebl Int. 2014 Oct 3;111(40):682
  Wessler, Ignatz
  
• Effect of LIF-withdrawal on acetylcholine synthesis in the embryonic stem cell line CGR8 is not mediated by STAT3, PI3Ks or cAMP/PKA pathways. Int Immunopharmacol. 2015 Nov;29(1):115-8
  Michel-Schmidt, Rosmarie; Kirkpatrick, Charles James & Wessler, Ignaz
  
• Murine embryonic stem cell line CGR8 expresses all subtypes of muscarinic receptors and multiple nicotinic receptor subunits: Down-regulation of α4- and β4-subunits during early differentiation. Int Immunopharmacol. 2015 Nov;29(1):110-4
  Kaltwasser, Susanne; Schmitz, Luise; Michel-Schmidt, Rosmarie; Anspach, Laura; Kirkpatrick, Charles James & Wessler, Ignaz
  
• PH-dependent hydrolysis of acetylcholine: Consequences for non-neuronal acetylcholine. Int Immunopharmacol. 2015 Nov;29(1):27-30
  Wessler, Ignaz; Michel-Schmidt, Rosmarie & Kirkpatrick, Charles James
  
• Recent progress in revealing the biological and medical significance of the nonneuronal cholinergic system. Int Immunopharmacol. 2015 Nov;29(1):1-7
  Grando, Sergei A.; Kawashima, Koichiro; Kirkpatrick, Charles J.; Kummer, Wolfgang & Wessler, Ignaz
  
• Detection of Non-neuronal Acetylcholine In: Muscarinic receptors: From Structure to animal models, Myslivecek J, Jakubik J (ed), Neuromethods 107, 205- 220, Springer+Business Media New York 2016
  Wessler, Ignaz Karl & Kirkpatrick, Charles James
  
• Honeybees produce millimolar concentrations of non-neuronal acetylcholine for breeding: possible adverse effects of neonicotinoids. Plosone
  Wessler, Ignaz; Gärtner, Hedwig-Annabel; Michel-Schmidt, Rosmarie; Brochhausen, Christoph; Schmitz, Luise; Anspach, Laura; Grünewald, Bernd & Kirkpatrick, Charles James