Expression und Funktion des nicht-neuronalen cholinergen Systems bei murinen embryonalen Stammzellen

• Antragsteller: Professor Charles James Kirkpatrick, Ph.D.
• Fachliche Zuordnung: Pathologie
• Förderung: Förderung von 2010 bis 2016
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 164641675

• Erstellungsjahr: 2016

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Honeybees produce millimolar concentrations of non-neuronal acetylcholine for breeding: possible adverse effects of neonicotinoids. Plosone
  Wessler I, Gärtner HA, Michel-Schmidt R, Brochhausen Ch, Schmitz L, Anspach L, Grünewald B, Kirkpatrick JC
  
• Expression of muscarinic receptors on the murine embryonic stem cell line CGR8. Autonomic Neuroscience: Basic and Clinical 177, 61, 2013
  Wessler I, Kaltwasser S, Tsaryk R, Michel-Schmidt R, Kirkpatrick CJ
  
• Tumor-promoting activities of nicotine not addressed. Dtsch Arztebl Int. 2014 Oct 3;111(40):682
  Wessler I
  
• Effect of LIF-withdrawal on acetylcholine synthesis in the embryonic stem cell line CGR8 is not mediated by STAT3, PI3Ks or cAMP/PKA pathways. Int Immunopharmacol. 2015 Nov;29(1):115-8
  Michel-Schmidt R, Kirkpatrick CJ, Wessler I
  
• Murine embryonic stem cell line CGR8 expresses all subtypes of muscarinic receptors and multiple nicotinic receptor subunits: Down-regulation of α4- and β4-subunits during early differentiation. Int Immunopharmacol. 2015 Nov;29(1):110-4
  Kaltwasser S, Schmitz L, Michel-Schmidt R, Anspach L, Kirkpatrick CJ, Wessler I
  
• PH-dependent hydrolysis of acetylcholine: Consequences for non-neuronal acetylcholine. Int Immunopharmacol. 2015 Nov;29(1):27-30
  Wessler I, Michel-Schmidt R, Kirkpatrick CJ
  
• Recent progress in revealing the biological and medical significance of the nonneuronal cholinergic system. Int Immunopharmacol. 2015 Nov;29(1):1-7
  Grando SA, Kawashima K, Kirkpatrick CJ, Kummer W, Wessler I
  
• Detection of Non-neuronal Acetylcholine In: Muscarinic receptors: From Structure to animal models, Myslivecek J, Jakubik J (ed), Neuromethods 107, 205- 220, Springer+Business Media New York 2016
  Wessler I, Kirkpatrick CJ