Expression and function of the non-neuronal cholinergic system in murine embryonic stem cells

• Applicant: Professor Charles James Kirkpatrick, Ph.D.
• Subject Area: Pathology
• Term: from 2010 to 2016
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 164641675

• Final Report Year: 2016

Final Report Abstract

No abstract available

Publications

• Honeybees produce millimolar concentrations of non-neuronal acetylcholine for breeding: possible adverse effects of neonicotinoids. Plosone
  Wessler I, Gärtner HA, Michel-Schmidt R, Brochhausen Ch, Schmitz L, Anspach L, Grünewald B, Kirkpatrick JC
  (See online at https://doi.org/10.1371/journal.pone.0156886)
• Expression of muscarinic receptors on the murine embryonic stem cell line CGR8. Autonomic Neuroscience: Basic and Clinical 177, 61, 2013
  Wessler I, Kaltwasser S, Tsaryk R, Michel-Schmidt R, Kirkpatrick CJ
  (See online at https://doi.org/10.1016/j.autneu.2013.05.134)
• Tumor-promoting activities of nicotine not addressed. Dtsch Arztebl Int. 2014 Oct 3;111(40):682
  Wessler I
  (See online at https://dx.doi.org/10.3238/arztebl.2014.0682a)
• Effect of LIF-withdrawal on acetylcholine synthesis in the embryonic stem cell line CGR8 is not mediated by STAT3, PI3Ks or cAMP/PKA pathways. Int Immunopharmacol. 2015 Nov;29(1):115-8
  Michel-Schmidt R, Kirkpatrick CJ, Wessler I
  (See online at https://doi.org/10.1016/j.intimp.2015.04.005)
• Murine embryonic stem cell line CGR8 expresses all subtypes of muscarinic receptors and multiple nicotinic receptor subunits: Down-regulation of α4- and β4-subunits during early differentiation. Int Immunopharmacol. 2015 Nov;29(1):110-4
  Kaltwasser S, Schmitz L, Michel-Schmidt R, Anspach L, Kirkpatrick CJ, Wessler I
  (See online at https://doi.org/10.1016/j.intimp.2015.07.028)
• PH-dependent hydrolysis of acetylcholine: Consequences for non-neuronal acetylcholine. Int Immunopharmacol. 2015 Nov;29(1):27-30
  Wessler I, Michel-Schmidt R, Kirkpatrick CJ
  (See online at https://doi.org/10.1016/j.intimp.2015.04.039)
• Recent progress in revealing the biological and medical significance of the nonneuronal cholinergic system. Int Immunopharmacol. 2015 Nov;29(1):1-7
  Grando SA, Kawashima K, Kirkpatrick CJ, Kummer W, Wessler I
  (See online at https://doi.org/10.1016/j.intimp.2015.08.023)
• Detection of Non-neuronal Acetylcholine In: Muscarinic receptors: From Structure to animal models, Myslivecek J, Jakubik J (ed), Neuromethods 107, 205- 220, Springer+Business Media New York 2016
  Wessler I, Kirkpatrick CJ
  (See online at https://dx.doi.org/10.1007/978-1-4939-2858-3_11)