Mechanisms controlling cell adhesion and motility in zebrafish stem cell proliferation zones (A01)

• Subject Area: Developmental Biology
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 89986987

Developmental stem cell niches provide a paradigm for cells leaving a tightly controlled adhesion environment to invade adjacent tissues. In A1 cell behavior in the dorsal thalamic neural proliferation zone will be studied by combining genetic approaches, live-imaging and single cell transcriptomics for identifying and studying the molecular control of adhesion and migration. Ultimately this project aims for understanding the transitions that stem cells undergo by leaving their niche to become migrating progenitors.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 850: Control of Cell Motility in Morphogenesis, Cancer Invasion and Metastasis
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Head: Professor Dr. Wolfgang Driever