Connectivity and function of regenerated neurons in the cerebral cortex – from transplantation to direct neuronal reprogramming (A06)

• Subject Area: Developmental Neurobiology ; Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2010 to 2021
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 118803580

In the previous funding period we have used a selective ablation model to show the appropriate integration of neurons transplanted from fetal cerebral cortex into the adult murine visual cortex. In the present project we aim first to move this approach towards more clinically relevant models such as traumatic brain injury also in older mice and examine myelination of the transplanted neurons, a key question as regenerating mature neurons fail to be myelinated. In the second project part we will examine the integration and axonal myelination of new neurons obtained by direct reprogramming from local reactive glial cells, based on the breakthrough in this approach after traumatic brain injury we achieved in the last funding period using the read-outs from in coll. with A08.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 870: Assembly and Function of Neuronal Circuits in Sensory Processing
• Applicant Institution: Ludwig-Maximilians-Universität München
• Project Head: Professorin Dr. Magdalena Götz