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Structure and function of the cyanobacterial color sensor Cph2

Fachliche Zuordnung Stoffwechselphysiologie, Biochemie und Genetik der Mikroorganismen
Strukturbiologie
Förderung Förderung von 2010 bis 2014
Projektkennung Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 171106024
 
Cyanobacterial phytochromes are a diverse family of light receptors controlling different biological cell functions including phototaxis. Among canonical bona fide phytochromes of the well characterized plant-type clade, cyanobacteria also harbor phytochromes that absorb green, violet or blue light. The Synechocystis sp. PCC 6803 photoreceptor Cph2 is both a red/far-red and blue light sensor. It regulates phototaxis possibly via alterations in the c-di-GMP level. We have analyzed spectroscopic characteristics of the two light-absorbing domains and started to crystallize them for detailed analysis. Here, we will combine the expertise of two laboratories working together on a structural and biological base to unravel the mechanism how two different light signals are processed and transmitted by one photosensor, Cph2. Structural and biochemical information will be correlated to biological output, namely alterations in phototaxis and c-di-GMP level.
DFG-Verfahren Sachbeihilfen
 
 

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