Mechanism of gene regulation by CcpA bound to cre sites located upstream, downstream and overlapping the regulated promoter

• Antragsteller: Professor Dr. Jörg Stülke, seit 10/2010; Professor Dr. Uwe Völker
• Fachliche Zuordnung: Stoffwechselphysiologie, Biochemie und Genetik der Mikroorganismen
• Förderung: Förderung von 2010 bis 2015
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 175812556

• Erstellungsjahr: 2015

Zusammenfassung der Projektergebnisse

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• (2011) Crh, the paralog of the phosphocarrier protein HPr, controls the methylglyoxal bypass of glycolysis in Bacillus subtilis. Mol. Microbiol. 82: 770-787
  Landmann, J. J., Busse, R. A., Latz, J.-H., Singh, K. D., Stülke, J., & Görke, B.
  
• (2011) Malate-mediated carbon catabolite repression in Bacillus subtilis involves the HPrK/CcpA pathway. J. Bacteriol. 193: 6939-6949
  Meyer, F. M., Jules, M., Mehne, F. M. P., Le Coq, D., Landmann, J. J., Görke, B., Aymerich, S., & Stülke, J.
  
• (2011) Physical interactions between tricarboxylic acid cycle enzymes in Bacillus subtilis: evidence for a metabolon. Metabolic Engineering, 13: 18-27
  Meyer, F. M., Gerwig, J., Hammer, E., Herzberg, C., Commichau, F. M., Völker, U., Stülke, J.
  
• (2012) CcpA forms complexes with CodY and RpoA in Bacillus subtilis. FEBS J. 279: 2201-2214
  Wünsche, A., Hammer, E., Bartholomae, M., Völker, U., Burkovski, A., Seidel, G., Hillen, W.
  
• (2013) Cyclic-di- AMP homeostasis in Bacillus subtilis: both lack and high-level accumulation of the nucleotide are detrimental for cell growth. J. Biol. Chem. 288: 2004-2017
  Mehne, F. M. P., Gunka, K., Eilers, H., Herzberg, C., Kaever, V., & Stülke, J.
  
• (2014) Control of the diadenylate cyclase CdaS in Bacillus subtilis: An autoinhibitory domain limits c-di-AMP production. J. Biol. Chem. 289: 21098-21107
  Mehne, F. M. P., Schröder-Tittmann, K., Eijlander, R. T., Herzberg, C., Hewitt, L., Kaever, V., Lewis, R. J., Kuipers, O. P., Tittmann, K., & Stülke, J.
  
• (2014) SubtiWiki – a database for the model organism Bacillus subtilis that links pathway, interaction and expression information. Nucleic Acids Res. 42: D692-D698
  Michna, R. H., Commichau, F. M., Tödter, D., Zschiedrich, C. P., & Stülke, J.
  
• (2014) The YmdB phosphodiesterase is a global regulator of late adaptive responses in Bacillus subtilis. J. Bacteriol. 196: 265-275
  Diethmaier, C., Newman, J. A., Kovács, Á. T., Kaever, Herzberg, C., Rodrigues, C., Boonstra, M., Kuipers, O. P., Lewis, R. J., & Stülke, J.
  
• (2015) Structural and biochemical analysis of the essential diadenylate cyclase CdaA from Listeria monocytogenes. J. Biol. Chem. First Published on January 20, 2015
  Rosenberg, J., Dickmanns, A., Neumann, P., Gunka, K., Arens, J., Kaever, V., Stülke, J., Ficner, R., & Commichau, F. M.
  
• Identification, Characterization, and Structure Analysis of the Cyclic di-AMP-binding PII-like Signal Transduction Protein DarA. J. Biol. Chem., January 30, 2015, The Journal of Biological Chemistry, 290, 3069-3080. First Published on November 28, 2014
  Gundlach, J., Dickmanns, A., Schröder-Tittmann, K., Neumann, P., Kampf, J., Herzberg, C., Hammer, E., Schwede, F., Kaever, V., Tittmann, K., Stülke, J., & Ficner, R.