Mechanism of gene regulation by CcpA bound to cre sites located upstream, downstream and overlapping the regulated promoter

• Applicants: Professor Dr. Jörg Stülke, since 10/2010; Professor Dr. Uwe Völker
• Subject Area: Metabolism, Biochemistry and Genetics of Microorganisms
• Term: from 2010 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 175812556

• Final Report Year: 2015

No abstract available

Publications

• (2011) Crh, the paralog of the phosphocarrier protein HPr, controls the methylglyoxal bypass of glycolysis in Bacillus subtilis. Mol. Microbiol. 82: 770-787
  Landmann, J. J., Busse, R. A., Latz, J.-H., Singh, K. D., Stülke, J., & Görke, B.
  
• (2011) Malate-mediated carbon catabolite repression in Bacillus subtilis involves the HPrK/CcpA pathway. J. Bacteriol. 193: 6939-6949
  Meyer, F. M., Jules, M., Mehne, F. M. P., Le Coq, D., Landmann, J. J., Görke, B., Aymerich, S., & Stülke, J.
  
• (2011) Physical interactions between tricarboxylic acid cycle enzymes in Bacillus subtilis: evidence for a metabolon. Metabolic Engineering, 13: 18-27
  Meyer, F. M., Gerwig, J., Hammer, E., Herzberg, C., Commichau, F. M., Völker, U., Stülke, J.
  
• (2012) CcpA forms complexes with CodY and RpoA in Bacillus subtilis. FEBS J. 279: 2201-2214
  Wünsche, Andrea; Hammer, Elke; Bartholomae, Maike; Völker, Uwe; Burkovski, Andreas; Seidel, Gerald & Hillen, Wolfgang
  
• (2013) Cyclic-di- AMP homeostasis in Bacillus subtilis: both lack and high-level accumulation of the nucleotide are detrimental for cell growth. J. Biol. Chem. 288: 2004-2017
  Mehne, Felix M.P.; Gunka, Katrin; Eilers, Hinnerk; Herzberg, Christina; Kaever, Volkhard & Stülke, Jörg
  
• (2014) SubtiWiki – a database for the model organism Bacillus subtilis that links pathway, interaction and expression information. Nucleic Acids Res. 42: D692-D698
  Michna, Raphael H.; Commichau, Fabian M.; Tödter, Dominik; Zschiedrich, Christopher P. & Stülke, Jörg
  
• (2014) The YmdB phosphodiesterase is a global regulator of late adaptive responses in Bacillus subtilis. J. Bacteriol. 196: 265-275
  Diethmaier, C.; Newman, J. A.; Kovacs, A. T.; Kaever, V.; Herzberg, C.; Rodrigues, C.; Boonstra, M.; Kuipers, O. P.; Lewis, R. J. & Stulke, J.
  
• (2014) Control of the diadenylate cyclase CdaS in Bacillus subtilis: An autoinhibitory domain limits c-di-AMP production. J. Biol. Chem. 289: 21098-21107
  Mehne, Felix M.P.; Schröder-Tittmann, Kathrin; Eijlander, Robyn T.; Herzberg, Christina; Hewitt, Lorraine; Kaever, Volkhard; Lewis, Richard J.; Kuipers, Oscar P.; Tittmann, Kai & Stülke, Jörg
  
• (2015) Structural and biochemical analysis of the essential diadenylate cyclase CdaA from Listeria monocytogenes. J. Biol. Chem. First Published on January 20, 2015
  Rosenberg, Jonathan; Dickmanns, Achim; Neumann, Piotr; Gunka, Katrin; Arens, Johannes; Kaever, Volkhard; Stülke, Jörg; Ficner, Ralf & Commichau, Fabian M.
  
• Identification, Characterization, and Structure Analysis of the Cyclic di-AMP-binding PII-like Signal Transduction Protein DarA. J. Biol. Chem., January 30, 2015, The Journal of Biological Chemistry, 290, 3069-3080. First Published on November 28, 2014
  Gundlach, Jan; Dickmanns, Achim; Schröder-Tittmann, Kathrin; Neumann, Piotr; Kaesler, Jan; Kampf, Jan; Herzberg, Christina; Hammer, Elke; Schwede, Frank; Kaever, Volkhard; Tittmann, Kai; Stülke, Jörg & Ficner, Ralf