Biochemische Untersuchungen des Myxobakteriums Myxociccus xanthus während der Fruchtkörperbildung

• Antragsteller: Professor Dr. Helge Björn Bode
• Fachliche Zuordnung: Pharmazie
• Förderung: Förderung von 2006 bis 2012
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 17649467

The proposed project deals with the physiology of the myxobacterium Myxococcus xanthus that forms fruiting bodies under starvation conditions. In these fruiting bodies vegetative cells develop into stress-resistant myxospores. In order to understand the underlying processes and to identify biomarkers that are characteristic and/or essential for this development, qualitative and quantitative changes in the composition of several classes of compounds (fatty acids, carbohydrates, amino acids) should be investigated. Thus this work is the basis for a detailed metabolic flux analysis which is essential to optimize selected metabolic pathways especially with respect to the production of pharmaceutically important compounds (antibiotics, anti-cancer compounds), whose formation is typical for myxobacteria.

• DFG-Verfahren: Emmy Noether-Nachwuchsgruppen