Etablierung eines humanen ex-vivo Zellkultur-Modells aus "reprogrammierten" Fibroblasten (iPS-Zellen) von Parkinson-Patienten mit LRRK2-Muation

• Applicant: Dr. Martina Wölfle
• Subject Area: Molecular and Cellular Neurology and Neuropathology
• Term: from 2010 to 2013
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 176910480

• Final Report Year: 2014

Final Report Abstract

No abstract available

Publications

• Genetic Correction of a LRRK2-Mutation in Human iPSCs Links Parkinsonian Neurodgeneration to ERK-Dependent Changes in Gene Expression. Cell Stem Cell. 2013 Mar 7;12(3):354-67
  Reinhardt P, Schmid B, Burbulla LF, Schöndorf DC, Wagner L, Glatza M, Höing S, Hargus G, Heck SA, Dhingra A, Wu G, Müller S, Brockmann K, Kluba T, Maisel M*, Krüger R, Berg D, Tsytsyura Y, Thiel CS, Psathaki OE, Klingauf J, Kuhlmann T, Klewin M, Müller H, Gasser T, Schöler HR, Sterneckert J
  (See online at https://doi.org/10.1016/j.stem.2013.01.008)