KFO 142:  Molekulare und zelluläre Alterung - Von den Wirkmechanismen zur klinischen Perspektive

• Fachliche Zuordnung: Medizin
• Förderung: Förderung von 2006 bis 2017
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 17771695

• Erstellungsjahr: 2016

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• The immunogenicity of adenovirus vectors limits the multispecificity of CD8 T-cell responses to vector-encoded transgenic antigens. Molecular Therapy, Vol. 16. 2008, Issue 9, pp. 1609-1616.
  Schirmbeck, Reinhold; Reimann, Jörg; Kochanek, Stefan & Kreppel, Florian
  
• Mice with a mutation in the dynein heavy chain 1 gene display sensory neuropathy but lack motor neuron disease. Experimental Neurology, Vol. 215. 2009, Issue 1, pp. 146-152.
  Dupuis, Luc; Fergani, Anissa; Braunstein, Kerstin E.; Eschbach, Judith; Holl, Nathalie; Rene, Frédérique; Gonzalez De Aguilar, Jose-Luis; Zoerner, Björn; Schwalenstocker, Birgit; Ludolph, Albert C. & Loeffler, Jean-Philippe
  
• p53 deletion impairs clearance of chromosomal-instable stem cells in aging telomere-dysfunctional mice. Nature Genetics, Vol. 41.2009, pp. 1138–1143.
  Begus-Nahrmann, Yvonne; Lechel, André; Obenauf, Anna C; Nalapareddy, Kodandaramireddy; Peit, Elvira; Hoffmann, Eva; Schlaudraff, Falk; Liss, Birgit; Schirmacher, Peter; Kestler, Hans; Danenberg, Esther; Barker, Nick; Clevers, Hans; Speicher, Michael R & Rudolph, K Lenhard
  
• Reactive oxygen intermediate-induced pathomechanisms contribute to immunosenescence, chronic inflammation and autoimmunity. Mechanisms of Ageing and Development, Vol. 130. 2009, Issue 9, pp. 564-587.
  Peters, Thorsten; Weiss, Johannes M.; Sindrilaru, Anca; Wang, Honglin; Oreshkova, Tsvetelina; Wlaschek, Meinhard; Maity, Pallab; Reimann, Jörg & Scharffetter-Kochanek, Karin
  
• Imaging Hematopoietic Stem Cells in the Marrow of Long Bones In Vivo. In: M.D. Filippi, H. Geiger (Eds.) Cell Migration Methods and Protocols. Methods in Molecular Biology, Vol. 750.2011, pp. 215-224.
  Köhler, Anja; Geiger, Hartmut & Gunzer, Matthias
  
• Reversal of UVA Skin Photosensitivity and DNA Damage in kidney transplant recipientsbyreplacingazathioprine. American Journal of Transplantation, Vol. 12. 2012, Issue 1, pp. 218-225.
  Hofbauer, G.F.L.; Attard, N.R.; Harwood, C.A.; McGregor, J.M.; Dziunycz, P.; Iotzova-Weiss, G.; Straub, G.; Meyer, R.; Kamenisch, Y.; Berneburg, M.; French, L.E.; Wüthrich, R.P.; Karran, P. & Serra, A.L.
  
• The cerebro-morphological fingerprint of a progeroid syndrome: white matter changes correlate with neurological symptoms in xeroderma pigmentosum. PLoSOne, Vol. 7. 2012, Issue 2: e30926.
  Kassubek, Jan; Sperfeld, Anne-Dorte; Pinkhardt, Elmar H.; Unrath, Alexander; Müller, Hans-Peter; Scharffetter-Kochanek, Karin; Ludolph, Albert C. & Berneburg, Mark
  
• Telomerase stimulates ribosomal DNA transcription under hyperproliferative conditions. Nature Communications, Vol. 5. 2014, Article number 4599.
  Gonzalez, Omar Garcia; Assfalg, Robin; Koch, Sylvia; Schelling, Adrian; Meena, Jitendra K.; Kraus, Johann; Lechel, Andre; Katz, Sarah-Fee; Benes, Vladimir; Scharffetter-Kochanek, Karin; Kestler, Hans A.; Günes, Cagatay & Iben, Sebastian
  
• Foxn1 Protein Expression in the Developing, Aging, and Regenerating Thymus. Journal of Immunology, Vol. 195. 2015, Issue 12, pp. 5678-5687.
  Rode, Immanuel; Martins, Vera C.; Küblbeck, Günter; Maltry, Nicole; Tessmer, Claudia & Rodewald, Hans-Reimer
  
• Neuronal redox imbalance results in altered energy homeostasis and early postnatal lethality. FASEB Journal, Vol. 29. 2015, Issue 7, pp. 2843-2858.
  Maity‐Kumar, Gandhari; Thal, Dietmar R.; Baumann, Bernd; Scharffetter‐Kochanek, Karin & Wirth, Thomas