Mathematical modeling of stem cell renewal and differentiation (B08)

• Subject Area: Bioinformatics and Theoretical Biology
• Term: from 2010 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 122491522

The focus of this project is mathematical modeling of mechanisms and dynamics of cell fate and growth regulation in stem cell based systems in development, tissue regeneration, and cancer. Mathe-matical modeling has become a powerful tool to address key questions in model systems and to pro-vide a mechanistic understanding of the underlying processes. In tight collaboration with experimental groups, mathematical models will be built and validated iteratively, based on data provided by collabo-rating projects. The research will contribute to a better understanding of of cell population dynamics and clonal heterogeneity. In addition, it will also allow comparing design principles of different stem cell systems.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 873: Maintenance and Differentiation of Stem Cells in Development und Disease
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Head: Professorin Dr. Anna Marciniak-Czochra