Genome and population dynamics during chronic infection with Helicobacter pylori (A01)

• Subject Area: Medical Microbiology and Mycology, Hygiene, Molecular Infection Biology
• Term: from 2010 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 158989968

Extensive genetic variability is a hallmark of the gastric carcinogenic pathogen Helicobacter pylori and contributes to its ability to adapt to individual human hosts. Using a combination of different high-throughput sequencing technologies with genetic and biochemical experimental approaches, this project aims at characterizing the dynamics of the evolution of the Helicobacter pylori genome during chronic infection, and to dissect the molecular mechanisms underlying the genetic diversification of this organism.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 900: Chronic Infections: Microbial Persistence and its Control
• Applicant Institution: Medizinische Hochschule Hannover
• Project Head: Professor Dr. Sebastian Suerbaum