Characterization of nuclear IL-1-regulated protein complexes that mediate chemokine gene expression (B02)

• Subject Area: General Genetics and Functional Genome Biology
• Term: from 2010 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 109546710

The cytokine interleukin(IL)-1 regulates inflammatory cell functions through a largely unexplored nuclear signaling network. In the preceding funding period we found evidence for (i) IL-1-specific enhancers, (ii) novel components that are assembled at IL-1-regulated regions within chromatin and (iii) cytokine-mediated changes in chromatin structure. We plan to reveal the underlying mechanisms by genome-editing and to test the concept of inflammatory transcription factories. Identification of such nuclear control points will open new options to modulate the biological activity of IL-1 in disease.

• DFG Programme: CRC/Transregios
• Subproject of: TRR 81: Chromatin Changes in Differentiation and Malignancies
• Applicant Institution: Philipps-Universität Marburg
• Project Head: Professor Dr. Michael Kracht