KFO 146:  Zellvermittelte Suppression von auto- und alloreaktiven Immunreaktionen

• Fachliche Zuordnung: Medizin
• Förderung: Förderung von 2006 bis 2013
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 18407128

• Erstellungsjahr: 2016

Keine Zusammenfassung vorhanden

Projektbezogene Publikationen (Auswahl)

• Lineage-specific DNA methylation in T cells correlates with histone methylation and enhancer activity. Genome Research, Vol. 19. 2009, pp. 1165-1174.
  Schmidl, Christian; Klug, Maja; Boeld, Tina J.; Andreesen, Reinhard; Hoffmann, Petra; Edinger, Matthias & Rehli, Michael
  
• Primary human colonic epithelial cells are transiently protected from anoikis by a Src-dependent mechanism. Biochemical and Biophysical Research Communications, Vol. 390. 2009, Issue 3, pp. 908-914.
  Hofmann, Claudia; Lippert, Elisabeth; Falk, Werner; Schölmerich, Jürgen; Rogler, Gerhard & Obermeier, Florian
  
• Basophils support the survival of plasma cells in mice. Journal of Immunology, Vol. 185. 2010, Issue 12, pp. 7180-7185.
  Gomez, Manuel Rodriguez; Talke, Yvonne; Goebel, Nicole; Hermann, Fabian; Reich, Barbara & Mack, Matthias
  
• Human regulatory macrophages. In: Suppression and Regulation of Immune Responses - Methods and Protocols, eds.: Maria Cristina Cuturi, Ignacio Anegon. Methods in Molecular Biology(MIMB), Vol. 677. 2011, pp. 181-192.
  Hutchinson, James A.; Riquelme, Paloma; Geissler, Edward K. & Fändrich, Fred
  
• Isolation of intact genomic DNA from FOXP3-sorted human regulatory T cells for epigenetic analyses. European Journal of Immunology, Vol. 40. 2010, Issue 5, pp. 1510–1512.
  Hansmann, Leo; Schmidl, Christian; Boeld, Tina J.; Andreesen, Reinhard; Hoffmann, Petra; Rehli, Michael & Edinger, Matthias
  
• T-cell dependent protective effects of CpG-ODN in experimental colitis are mediated by CD11c+ dendritic cells. Gut, Vol. 59.2010, Issue 10, pp. 1347-1354.
  Hofmann, C.; Dunger, N.; Grunwald, N.; Hammerling, G. J.; Hoffmann, P.; Scholmerich, J.; Falk, W. & Obermeier, F.
  
• Cutting Edge: Immunological consequences and trafficking of human regulatory macrophages administered to renal transplant recipients. Journal of Immunology, Vol. 187. 2011, Issue 5, pp. 2072-2078.
  Hutchinson, James A.; Riquelme, Paloma; Sawitzki, Birgit; Tomiuk, Stefan; Miqueu, Patrick; Zuhayra, Maaz; Oberg, Hans H.; Pascher, Andreas; Lützen, Ulf; Janßen, Uwe; Broichhausen, Christiane; Renders, Lutz; Thaiss, Friedrich; Scheuermann, Ernst; Henze, Eberhard; Volk, Hans-Dieter; Chatenoud, Lucienne; Lechler, Robert I.; Wood, Kathryn J.; ... & Fändrich, Fred
  
• Epigenetic reprogramming of the RORC locus during in vitro expansion is a distinctive feature of human memory but not naive Treg. European Journal of Immunology, Vol. 41. 2011, Issue 5, pp. 1491–1498.
  Schmidl, Christian; Hansmann, Leo; Andreesen, Reinhard; Edinger, Matthias; Hoffmann, Petra & Rehli, Michael
  
• ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression. Nature Medicine, vol. 18. 2012, pp. 128–134.
  Hoetzenecker, Wolfram; Echtenacher, Bernd; Guenova, Emmanuella; Hoetzenecker, Konrad; Woelbing, Florian; Brück, Jürgen; Teske, Anna; Valtcheva, Nadejda; Fuchs, Kerstin; Kneilling, Manfred; Park, Ji-Hyeon; Kim, Kyu-Han; Kim, Kyu-Won; Hoffmann, Petra; Krenn, Claus; Hai, Tsonwin; Ghoreschi, Kamran; Biedermann, Tilo & Röcken, Martin
  
• Studies on galactofuranose-containing glycostructures of the pathogenic mold Aspergillus fumigatus. International Journal of Medical Microbiology, Vol. 301. 2011, Issue 6, pp. 523-530.
  Heesemann, Leonie; Kotz, Andrea; Echtenacher, Bernd; Broniszewska, Marzena; Routier, Françoise; Hoffmann, Petra & Ebel, Frank
  
• IL-33 attenuates development and perpetuation of chronic intestinal inflammation. Inflammatory Bowel Diseases, Vol. 18. 2012, Issue 10, pp. 1900–1909.
  Gro, Philipp; Doser, Kristina; Falk, Werner; Obermeier, Florian & Hofmann, Claudia
  
• Novel serial positive enrichment technology enables clinical multiparameter cell sorting. PLoS One, Vol. 7. 2012, Issue 4: e35798.
  Stemberger, Christian; Dreher, Stefan; Tschulik, Claudia; Piossek, Christine; Bet, Jeannette; Yamamoto, Tori N.; Schiemann, Matthias; Neuenhahn, Michael; Martin, Klaus; Schlapschy, Martin; Skerra, Arne; Schmidt, Thomas; Edinger, Matthias; Riddell, Stanley R.; Germeroth, Lothar & Busch, Dirk H.
  
• Regulatory macrophages as therapeutic targets and therapeutic agents in solid organ transplantation. Current Opinion in Organ Transplantation, Vol. 17. 2012, Issue 4, pp. 332–342.
  Broichhausen, Christiane; Riquelme, Paloma; Geissler, Edward K. & Hutchinson, James A.
  
• IFN-γ-induced iNOS expression in mouse regulatory macrophages prolongs allograft survival in fully immunocompetent recipients. Molecular Therapy, Vol. 21. 2013, Issue 2, pp. 409-422.
  Riquelme, Paloma; Tomiuk, Stefan; Kammler, Anja; Fändrich, Fred; Schlitt, Hans J.; Geissler, Edward K. & Hutchinson, James A.
  
• TLR5 stop codon polymorphism is associated with invasive aspergillosis after allogeneic stem cell transplantation. Medical Mycology, Vol. 51. 2013, Issue 8, pp. 818–825.
  Grube, Matthias; Loeffler, Juergen; Mezger, Markus; Krüger, Bernd; Echtenacher, Bernd; Hoffmann, Petra; Edinger, Matthias; Einsele, Hermann; Andreesen, Reinhard & Holler, Ernst
  
• Chondroitin sulfate activates B cells in vitro, expands CD138+ cells in vivo, and interferes with established humoral immune responses. Journal of Leukocyte Biology, Vol. 96, 2014, Issue 1, pp. 65–72.
  Brühl, Hilke; Cihak, Josef; Goebel, Nicole; Talke, Yvonne; Renner, Kerstin; Hermann, Fabian; Rodriguez-Gomez, Manuel; Reich, Barbara; Plachý, Jîŕi; Stangassinger, Manfred & Mack, Matthias
  
• Killer Artificial Antigen Presenting Cells (KaAPC) for efficient in vitro depletion of human antigen-specific T cells. Journal of Visualized Experiments, Vol. 90. 2014, e51859. (http://www.jove.com/ video/51859)
  Schütz, Christian; Fleck, Martin; Schneck, Jonathan P. & Oelke, Mathias
  
• Physiologic TLR9-CpG-DNA interaction is essential for the homeostasis of the intestinal immune system. Inflammatory Bowel Diseases, Vol. 20. 2014, Issue 1, pp. 136–143.
  Hofmann, Claudia; Dunger, Nadja; Doser, Kristina; Lippert, Elisabeth; Siller, Sebastian; Edinger, Matthias; Falk, Werner & Obermeier, Florian
  
• The enhancer and promoter landscape of human regulatory and conventional T-cell subpopulations. Blood, Vol. 123. 2014, Issue 17, pp. e68-e78.
  Schmidl, Christian; Hansmann, Leo; Lassmann, Timo; Balwierz, Piotr J.; Kawaji, Hideya; Itoh, Masayoshi; Kawai, Jun; Nagao-Sato, Sayaka; Suzuki, Harukazu; Andreesen, Reinhard; Hayashizaki, Yoshihide; Forrest, Alistair R. R.; Carninci, Piero; Hoffmann, Petra; Edinger, Matthias & Rehli, Michael
  
• Basophils inhibit proliferation of CD4+ T cells in autologous and allogeneic mixed lymphocyte reactions and limit disease activity in a murine model of graft versus host disease. Immunology, Vol. 145. 2015, Issue 2, pp. 202–212.
  Hermann, Fabian J.; Rodriguez Gomez, Manuel; Doser, Kristina; Edinger, Matthias; Hoffmann, Petra; Schiechl, Gabriela; Talke, Yvonne; Göbel, Nicole; Schmidbauer, Kathrin; Syed, Shahzad N.; Brühl, Hilke & Mack, Matthias