Cytotoxic T lymphocyte function in vitro and in vivo (A10)

• Subject Area: Molecular Biology and Physiology of Neurons and Glial Cells
• Term: from 2011 to 2022
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 157660137

We could show that endocytosis of cytotoxic granules contributes significantly to the killing capacity of cytotoxic T lymphocytes. With the help of lipid bilayer TIRF microscopy we will continue to investigate the molecular mechanism of endocytosis, including the Ca2+ and lipid dependence, on the single granule level. Furthermore, we will study T cell function in an in vivo model, the anterior chamber of the eye.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 894: Ca2+-Signalling: Molecular Mechanisms and Integrative Functions
• Applicant Institution: Universität des Saarlandes
• Project Heads: Dr. Varsha Pattu; Professor Dr. Jens Rettig, until 3/2022