Connecting Cytoskeletal changes in B lymphocytes upon antigen exposure: a critical role for the Src-family kinase Lyn.

• Antragstellerin: Dr. Simona Infantino
• Fachliche Zuordnung: Immunologie
• Förderung: Förderung von 2011 bis 2014
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 192788838

• Erstellungsjahr: 2014

Zusammenfassung der Projektergebnisse

We have determined that Lyn-deficient PC are hyper-responsive to the two survival factors we have tested, IL3 and IL6. This hyper-responsiveness manifests as significantly extended survival and increased phosphorylation of the STAT molecules downstream of their receptors. We have shown that Lyn is a negative regulator of PC survival and that identification of the pathways it regulates will reveal therapeutic targets that will permit the depletion of pathogenic PC in autoimmune patients.

Projektbezogene Publikationen (Auswahl)

• 2013. Feeling a little SYK after mixing BAFF with BCR. (Preview). Immunity. 38 (3): 406-8
  Simona Infantino, David M. Tarlinton
  
• 2014. Lyn limits cytokine responsiveness of plasma cells to restrict their accumulation. Experimental Hematology, August 2014, Volume 42, Issue 8, Supplement, Page S33-S68
  Fairfax, Kirsten; Infantino, Simona; Jones, Sarah; Hibbs, Margaret & Tarlinton, David