Connecting Cytoskeletal changes in B lymphocytes upon antigen exposure: a critical role for the Src-family kinase Lyn.

• Applicant: Dr. Simona Infantino
• Subject Area: Immunology
• Term: from 2011 to 2014
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 192788838

• Final Report Year: 2014

Final Report Abstract

We have determined that Lyn-deficient PC are hyper-responsive to the two survival factors we have tested, IL3 and IL6. This hyper-responsiveness manifests as significantly extended survival and increased phosphorylation of the STAT molecules downstream of their receptors. We have shown that Lyn is a negative regulator of PC survival and that identification of the pathways it regulates will reveal therapeutic targets that will permit the depletion of pathogenic PC in autoimmune patients.

Publications

• 2013. Feeling a little SYK after mixing BAFF with BCR. (Preview). Immunity. 38 (3): 406-8
  Simona Infantino, David M. Tarlinton
  
• 2014. Lyn limits cytokine responsiveness of plasma cells to restrict their accumulation. Experimental Hematology, August 2014, Volume 42, Issue 8, Supplement, Page S33-S68
  Fairfax, Kirsten; Infantino, Simona; Jones, Sarah; Hibbs, Margaret & Tarlinton, David