Modulation of miRNA Expression Reveals Plasticity of Human Immune Function (C)

• Subject Area: Immunology
• Term: from 2011 to 2015
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 178696424

Exogenous and endogenous ligands of Toll-like receptors (TLR) alter differentiation, maturation and function of myeloid and lymphoid cells. In part this is due to alterations in the micro RNA (miR) expression profiles of these cells. miRs are thereby not only indicators but also direct initiators of adaption or maintenance of cellular functional phenotypes. Based on two model systems (tolerogenic TLR-APC and IL-10-producing B cells) the interrelationship between exogenous signals (TLR), endogenous signaling, intracellular regulation (miR) and phenotypic function will be analyzed.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 938: Environment Specific Control of Immunological Reactivity
• Applicant Institution: Ruprecht-Karls-Universität Heidelberg
• Project Heads: Privatdozentin Dr. Isabelle Béatrice Bekeredjian-Ding, until 1/2012; Professor Dr. Klaus Michael Heeg