The protein sorting and assembly maschineries of the mitochondrial outer membrane (P22)

• Subject Area: Biochemistry
• Term: from 2011 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 26068018

The sorting and assembly machinery (SAM) and the mitochondrial import (MIM) complex mediate the biogenesis of mitochondrial outer membrane proteins. We have discovered that both protein sorting machineries form a dynamic network to mediate biogenesis of different types of membrane-integrated proteins. In this project we will test our hypothesis that coupling to different partner proteins modulates the substrate specificity of both protein machineries. Therefore, we will define docking sites for partner proteins and precursor proteins and analyze the function of the interaction with partner proteins in protein sorting.

• DFG Programme: Collaborative Research Centres
• Subproject of: SFB 746: Functional Specificity by Coupling and Modification of Proteins
• Applicant Institution: Albert-Ludwigs-Universität Freiburg
• Project Heads: Professor Dr. Thomas Becker; Professor Dr. Nikolaus Pfanner, until 12/2014