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GSC 1006:  Graduate School of Quantitative Biosciences Munich (QBM)

Subject Area Basic Research in Biology and Medicine
Term from 2012 to 2019
Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 194407719
 
Final Report Year 2020

Final Report Abstract

The molecular biosciences are undergoing a major paradigm shift – away from analyzing individual genes and proteins to studying large molecular machines and cellular pathways, with the ultimate goal of understanding biological systems in their entirety. The emerging study of biomolecular systems faces major methodological and conceptual challenges due to the need for quantitative approaches for the study and characterization of biological systems. This includes the development of sensitive quantitative assays, both for cell-based high throughput and for in vivo analyses; improved measurement techniques that ideally push resolution limits to the single molecule level; statistical methods capable of managing high-dimensional, often noisy, data sets; and mathematical modeling approaches that reduce the dimensionality of parameter spaces and produce mechanistically realistic, experimentally testable predictions. As a result, systemsoriented biological research is inherently an interdisciplinary undertaking, involving biochemistry/structural biology, molecular and organismal genetics, molecular biology, biophysics, biostatistics, bioinformatics, and theoretical physics. The mission of the Graduate School of Quantitative Biosciences Munich (QBM) is to provide a new generation of scientists with the skills and resources to excel in this new multi-disciplinary environment. The school offers a structured PhD program consisting of three components: an interdisciplinary research project, a program of formal lectures and course work including an interdisciplinary core course that covers key problems in bioscience from multiple perspectives, and activities to enhance students’ communication skills. Beyond its educational mission, the school provides a framework for interdisciplinary collaboration between the participating PIs and groups, thereby directly advancing the aims of quantitative, systems-oriented bioscience. The school was built on LMU Munich’s strengths in biochemistry and physics, complemented by adjacent disciplines, in particular applied mathematics and medicine, and by neighboring institutions (MPI Biochemistry, Helmholtz Center Munich). Encompassing a wide range of methodological approaches, the school concentrates thematically on the control of gene expression in all its aspects and the interplay of different control mechanisms in regulatory networks, a fundamental problem that is well suited for the envisioned quantitative and systemic analysis and has important medical implications. With its strong emphasis on anchoring theoretical analysis in advanced quantitative experimentation, its focus on the control of gene expression, and the excellence of the participating scientists, the school as of today has a unique position within the European scientific landscape.

Link to the final report

https://doi.org/10.2314/KXP:1702177580

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