EXC 1023:  ImmunoSensation: Das immunsensorische System

• Fachliche Zuordnung: Mikrobiologie, Virologie und Immunologie
• Förderung: Förderung von 2012 bis 2018
• Projektkennung: Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 194445620

• Erstellungsjahr: 2019

Zusammenfassung der Projektergebnisse

Das Immunsystem spielt für unsere Gesundheit, aber auch bei der Entstehung vieler Erkrankungen eine zentrale Rolle. Mit dem innovativen Konzept des immunsensorischen Systems, das Nicht-Immunzellen und die Interaktion mit dem Nervensystem sowie den Metabolismus mit einbezieht, hat sich ImmunoSensation zu einem der führenden Zentren für immunologische Forschung, insbesondere für angeborene Immunität, entwickelt. So wurden neue Liganden und Signalmoleküle identifiziert, eine neue Klassifikation von Makrophagen eingeführt, das Verständnis der Krebs-Immun-Interaktion erweitert, ein negativer Einfluss der westlichen Ernährung auf das Immunsystem entdeckt, sowie ein neuer Therapieansatz für die altersbedingte Verminderung der Gedächtnisleistung entwickelt. Zwei Biotech-Firmen wurden ausgegründet, und zwei neue Wirkstoffe befinden sich in klinischen Studien zur Tumortherapie. Internationale Forschungskooperationen mit Melbourne und Osaka konnten während der Clusterlaufzeit formalisiert werden und zentrale Themen wurden zu neuen Sonderforschungsbereichen weiterentwickelt. Für die Entwicklung des immunologischen Schwerpunkts war das internationale Rekrutierungskonzept von ImmunoSensation außerordentlich wichtig. An der Universität Bonn wurden seit 2012 zwölf Professuren für die Forschungsthematik eingerichtet und verstetigt, freigewordene Professuren auf dem Gebiet wurden im selben Themenfeld wiederbesetzt. Das Deutsche Zentrum für Neurodegenerative Erkrankungen (DZNE) hat zwei Professuren zur Neuroinflammation geschaffen. Über 20% der Berufungen waren international. Nachwuchswissenschaftler*innen mit ERC, NRW Rückkehrer oder Emmy-Noether Förderungen konnten erfolgreich nach Bonn geholt werden. Im Rahmen von ImmunoSensation aufgebaute Strukturen umfassen zwei englischsprachige Masterstudiengänge Medical Immunosciences and Infection und Immunobiology, die internationale Graduiertenschule Immunosciences and Infection, zentrale Forschungsplattformen und ein Koordinationsbüro zur operativen Umsetzung. Zur Infrastrukturentwicklung beigetragen haben der Neubaubeginn der Forschungsgebäude BMZ II und LIMES-TIS, sowie die Entwicklung der Core Facilities und deren Ausstattung mit neuen Forschungsgeräten. Maßnahmen zur Familienförderung wurden erfolgreich implementiert, wie z.B. die Einrichtung von zwei Familienzimmern und zusätzliche Betreuungsangebote für Kinder. Wissenschaftlerinnen wurden durch spezifische Projektförderung, Coaching und Netzwerkmöglichkeiten unterstützt. Neu eingerichtete Professuren wurden zu 50% mit Frauen besetzt und die Zahl der beteiligten Projektleiterinnen stieg von ursprünglich 19% auf 32% an. Insgesamt konnte ImmunoSensation, nicht zuletzt auch durch die Etablierung von Förderprogrammen für Nachwuchs und Gleichstellung, einen nachhaltigen Beitrag zum besseren Verständnis immunsensorischer Prozesse und zur Identifizierung neuer therapeutischer Ansätze leisten. Damit ist der Aufbau eines in Deutschland einmaligen und international sichtbaren wissenschaftlichen Zentrums für Immunologie gelungen.

Link zum Abschlussbericht

https://dx.doi.org/10.2314/KXP:1697312306

Projektbezogene Publikationen (Auswahl)

• (2012) Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation; Nature 490, 412-416
  Landsberg, J, Kohlmeyer, J, Renn, M, Bald, T, Rogava, M, Cron, M, Fatho, M, Lennerz, V, Wolfel, T, Holzel, M and Tuting, T
  
• (2013) A ligation-independent cloning technique for high-throughput assembly of transcription activator-like effector genes; Nat Biotechnol 31, 76-81
  Schmid-Burgk, JL, Schmidt, T, Kaiser, V, Honing, K and Hornung, V
  
• (2013) Activation and regulation of the inflammasomes; Nat Rev Immunol 13, 397-411
  Latz, E, Xiao, TS and Stutz, A
  
• (2013) Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP; Nature 503, 530-534
  Ablasser, A, Schmid-Burgk, JL, Hemmerling, I, Horvath, GL, Schmidt, T, Latz, E and Hornung, V
  
• (2013) cGAS produces a 2’-5’-linked cyclic dinucleotide second messenger that activates STING; Nature 498, 380-384
  Ablasser, A, Goldeck, M, Cavlar, T, Deimling, T, Witte, G, Rohl, I, Hopfner, KP, Ludwig, J and Hornung, V
  
• (2013) Cyclic [G(2’,5’)pA(3’,5’)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase; Cell 153, 1094-1107
  Gao, P, Ascano, M, Wu, Y, Barchet, W, Gaffney, BL, Zillinger, T, Serganov, AA, Liu, Y, Jones, RA, Hartmann, G, Tuschl, T and Patel, DJ
  
• (2013) Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression; J Clin Invest 123, 4242-4254
  Hochheiser, K, Heuser, C, Krause, TA, Teteris, S, Ilias, A, Weisheit, C, Hoss, F, Tittel, AP, Knolle, PA, Panzer, U, Engel, DR, Tharaux, PL and Kurts, C
  
• (2013) iGLuc: a luciferase-based inflammasome and protease activity reporter; Nat Methods 10, 147-154
  Bartok, E, Bauernfeind, F, Khaminets, MG, Jakobs, C, Monks, B, Fitzgerald, KA, Latz, E and Hornung, V
  
• (2013) Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis; Blood 122, 1779-1788
  Peng, WM, Maintz, L, Allam, JP, Raap, U, Gutgemann, I, Kirfel, J, Wardelmann, E, Perner, S, Zhao, W, Fimmers, R, Walgenbach, K, Oldenburg, J, Schwartz, LB and Novak, N
  
• (2013) Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection; Nat Immunol 14, 574-583
  Huang, LR, Wohlleber, D, Reisinger, F, Jenne, CN, Cheng, RL, Abdullah, Z, Schildberg, FA, Odenthal, M, Dienes, HP, van Rooijen, N, Schmitt, E, Garbi, N, Croft, M, Kurts, C, Kubes, P, Protzer, U, Heikenwalder, M and Knolle, PA
  
• (2013) Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo; Nature 498, 371-375
  Lammermann, T, Afonso, PV, Angermann, BR, Wang, JM, Kastenmuller, W, Parent, CA and Germain, RN
  
• (2013) NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice; Nature 493, 674-678
  Heneka, MT, Kummer, MP, Stutz, A, Delekate, A, Schwartz, S, Vieira-Saecker, A, Griep, A, Axt, D, Remus, A, Tzeng, TC, Gelpi, E, Halle, A, Korte, M, Latz, E and Golenbock, DT
  
• (2013) Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing; Immunity 39, 482-495
  Gehrke, N, Mertens, C, Zillinger, T, Wenzel, J, Bald, T, Zahn, S, Tuting, T, Hartmann, G and Barchet, W
  
• (2013) Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?; Nat Rev Cancer 13, 365-376
  Hölzel, M, Bovier, A and Tüting, T
  
• (2013) RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA; J Exp Med 210, 2447-2463
  Sirois, CM, Jin, T, Miller, AL, Bertheloot, D, Nakamura, H, Horvath, GL, Mian, A, Jiang, J, Schrum, J, Bossaller, L, Pelka, K, Garbi, N, Brewah, Y, Tian, J, Chang, C, Chowdhury, PS, Sims, GP, Kolbeck, R, Coyle, AJ, Humbles, AA, Xiao, TS and Latz, E
  
• (2013) Species-specific detection of the antiviral small-molecule compound CMA by STING; EMBO J 32, 1440-1450
  Cavlar, T, Deimling, T, Ablasser, A, Hopfner, KP and Hornung, V
  
• (2013) Structure-function analysis of STING activation by c[G(2’,5’)pA(3’,5’)p] and targeting by antiviral DMXAA; Cell 154, 748-762
  Gao, P, Ascano, M, Zillinger, T, Wang, W, Dai, P, Serganov, AA, Gaffney, BL, Shuman, S, Jones, RA, Deng, L, Hartmann, G, Barchet, W, Tuschl, T and Patel, DJ
  
• (2013) The immune system and kidney disease: basic concepts and clinical implications; Nat Rev Immunol 13, 738-753
  Kurts, C, Panzer, U, Anders, HJ and Rees, AJ
  
• (2013) Turning tumors into vaccines: co-opting the innate immune system; Immunity 39, 27-37
  van den Boorn, JG and Hartmann, G
  
• (2014) Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5’-diphosphates; Nature 514, 372-375
  Goubau, D, Schlee, M, Deddouche, S, Pruijssers, AJ, Zillinger, T, Goldeck, M, Schuberth, C, Van der Veen, AG, Fujimura, T, Rehwinkel, J, Iskarpatyoti, JA, Barchet, W, Ludwig, J, Dermody, TS, Hartmann, G and Reis e Sousa, C
  
• (2014) Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes; Nat Commun 5, 5236
  Kim, S, Becker, J, Bechheim, M, Kaiser, V, Noursadeghi, M, Fricker, N, Beier, E, Klaschik, S, Boor, P, Hess, T, Hofmann, A, Holdenrieder, S, Wendland, JR, Frohlich, H, Hartmann, G, Nothen, MM, Muller-Myhsok, B, Putz, B, Hornung, V and Schumacher, J
  
• (2014) Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium; Cell 156, 456-468
  Schiwon, M, Weisheit, C, Franken, L, Gutweiler, S, Dixit, A, Meyer-Schwesinger, C, Pohl, JM, Maurice, NJ, Thiebes, S, Lorenz, K, Quast, T, Fuhrmann, M, Baumgarten, G, Lohse, MJ, Opdenakker, G, Bernhagen, J, Bucala, R, Panzer, U, Kolanus, W, Grone, HJ, Garbi, N, Kastenmuller, W, Knolle, PA, Kurts, C and Engel, DR
  
• (2014) Cytosolic RNA:DNA hybrids activate the cGAS-STING axis; EMBO J 33, 2937-2946
  Mankan, AK, Schmidt, T, Chauhan, D, Goldeck, M, Honing, K, Gaidt, M, Kubarenko, AV, Andreeva, L, Hopfner, KP and Hornung, V
  
• (2014) Dendritic cell-targeted vaccines-- hope or hype?; Nat Rev Immunol 14, 705-711
  Kastenmuller, W, Kastenmuller, K, Kurts, C and Seder, RA
  
• (2014) Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases; Nat Commun 5, 3045
  Sommer, D, Peters, A, Wirtz, T, Mai, M, Ackermann, J, Thabet, Y, Schmidt, J, Weighardt, H, Wunderlich, FT, Degen, J, Schultze, JL and Beyer, M
  
• (2014) Efficient solid-phase synthesis of pppR- NA by using product-specific labeling; Angew Chem Int Ed Engl 53, 4694-4698
  Goldeck, M, Tuschl, T, Hartmann, G and Ludwig, J
  
• (2014) High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3; Nat Immunol 15, 152-160
  De Nardo, D, Labzin, LI, Kono, H, Seki, R, Schmidt, SV, Beyer, M, Xu, D, Zimmer, S, Lahrmann, C, Schildberg, FA, Vogelhuber, J, Kraut, M, Ulas, T, Kerksiek, A, Krebs, W, Bode, N, Grebe, A, Fitzgerald, ML, Hernandez, NJ, Williams, BR, Knolle, P, Kneilling, M, Rocken, M, Lutjohann, D, Wright, SD, Schultze, JL and Latz, E
  
• (2014) Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation; Cancer Discov 4, 674-687
  Bald, T, Landsberg, J, Lopez-Ramos, D, Renn, M, Glodde, N, Jansen, P, Gaffal, E, Steitz, J, Tolba, R, Kalinke, U, Limmer, A, Jonsson, G, Holzel, M and Tuting, T
  
• (2014) Innate immune activation in neurodegenerative disease; Nat Rev Immunol 14, 463-477
  Heneka, MT, Kummer, MP and Latz, E
  
• (2014) OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids; Nat Rev Immunol 14, 521-528
  Hornung, V, Hartmann, R, Ablasser, A and Hopfner, KP
  
• (2014) Selection of motor programs for suppressing food intake and inducing locomotion in the Drosophila brain; PLoS Biol 12, e1001893
  Schoofs, A, Huckesfeld, S, Schlegel, P, Miroschnikow, A, Peters, M, Zeymer, M, Spiess, R, Chiang, AS and Pankratz, MJ
  
• (2014) The adaptor ASC has extracellular and ‘prionoid’ activities that propagate inflammation; Nat Immunol 15, 727-737
  Franklin, BS, Bossaller, L, De Nardo, D, Ratter, JM, Stutz, A, Engels, G, Brenker, C, Nordhoff, M, Mirandola, SR, Al-Amoudi, A, Mangan, MS, Zimmer, S, Monks, BG, Fricke, M, Schmidt, RE, Espevik, T, Jones, B, Jarnicki, AG, Hansbro, PM, Busto, P, Marshak-Rothstein, A, Hornemann, S, Aguzzi, A, Kastenmuller, W and Latz, E
  
• (2014) Transcriptome-based network analysis reveals a spectrum model of human macrophage activation; Immunity 40, 274-288
  Xue, J, Schmidt, SV, Sander, J, Draffehn, A, Krebs, W, Quester, I, De Nardo, D, Gohel, TD, Emde, M, Schmidleithner, L, Ganesan, H, Nino-Castro, A, Mallmann, MR, Labzin, L, Theis, H, Kraut, M, Beyer, M, Latz, E, Freeman, TC, Ulas, T and Schultze, JL
  
• (2014) Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma; Nature 507, 109-113
  Bald, T, Quast, T, Landsberg, J, Rogava, M, Glodde, N, Lopez-Ramos, D, Kohlmeyer, J, Riesenberg, S, van den Boorn-Konijnenberg, D, Homig-Holzel, C, Reuten, R, Schadow, B, Weighardt, H, Wenzel, D, Helfrich, I, Schadendorf, D, Bloch, W, Bianchi, ME, Lugassy, C, Barnhill, RL, Koch, M, Fleischmann, BK, Forster, I, Kastenmuller, W, Kolanus, W, Holzel, M, Gaffal, E and Tuting, T
  
• (2015) A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2’O-Methylated Self RNA; Immunity 43, 41-51
  Schuberth-Wagner, C, Ludwig, J, Bruder, AK, Herzner, AM, Zillinger, T, Goldeck, M, Schmidt, T, Schmid-Burgk, JL, Kerber, R, Wolter, S, Stumpel, JP, Roth, A, Bartok, E, Drosten, C, Coch, C, Hornung, V, Barchet, W, Kummerer, BM, Hartmann, G and Schlee, M
  
• (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases; Nat Med 21, 248-255
  Coll, RC, Robertson, AA, Chae, JJ, Higgins, SC, Munoz-Planillo, R, Inserra, MC, Vetter, I, Dungan, LS, Monks, BG, Stutz, A, Croker, DE, Butler, MS, Haneklaus, M, Sutton, CE, Nunez, G, Latz, E, Kastner, DL, Mills, KH, Masters, SL, Schroder, K, Cooper, MA and O’Neill, LA
  
• (2015) CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer’s disease model; J Clin Invest 125, 365-378
  Krauthausen, M, Kummer, MP, Zimmermann, J, Reyes-Irisarri, E, Terwel, D, Bulic, B, Heneka, MT and Muller, M
  
• (2015) Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial; Clin Infect Dis 61, 517-526
  Debrah, AY, Specht, S, Klarmann-Schulz, U, Batsa, L, Mand, S, Marfo-Debrekyei, Y, Fimmers, R, Dubben, B, Kwarteng, A, Osei-Atweneboana, M, Boakye, D, Ricchiuto, A, Buttner, M, Adjei, O, Mackenzie, CD and Hoerauf, A
  
• (2015) Endocannabinoid signalling and the deteriorating brain; Nat Rev Neurosci 16, 30-42
  Di Marzo, V, Stella, N and Zimmer, A
  
• (2015) Functional classification of memory CD8(+) T cells by CX3CR1 expression; Nat Commun 6, 8306
  Bottcher, JP, Beyer, M, Meissner, F, Abdullah, Z, Sander, J, Hochst, B, Eickhoff, S, Rieckmann, JC, Russo, C, Bauer, T, Flecken, T, Giesen, D, Engel, D, Jung, S, Busch, DH, Protzer, U, Thimme, R, Mann, M, Kurts, C, Schultze, JL, Kastenmuller, W and Knolle, PA
  
• (2015) Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci; Nat Commun 6, 5966
  Betz, RC, Petukhova, L, Ripke, S, Huang, H, Menelaou, A, Redler, S, Becker, T, Heilmann, S, Yamany, T, Duvic, M, Hordinsky, M, Norris, D, Price, VH, Mackay-Wiggan, J, de Jong, A, DeStefano, GM, Moebus, S, Bohm, M, Blume-Peytavi, U, Wolff, H, Lutz, G, Kruse, R, Bian, L, Amos, CI, Lee, A, Gregersen, PK, Blaumeiser, B, Altshuler, D, Clynes, R, de Bakker, PIW, Noethen, MM, Daly, MJ and Christiano, AM
  
• (2015) Innate immunity in Alzheimer’s disease; Nat Immunol 16, 229-236
  Heneka, MT, Golenbock, DT and Latz, E
  
• (2015) MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment; Nat Commun 6, 8755
  Riesenberg, S, Groetchen, A, Siddaway, R, Bald, T, Reinhardt, J, Smorra, D, Kohlmeyer, J, Renn, M, Phung, B, Aymans, P, Schmidt, T, Hornung, V, Davidson, I, Goding, CR, Jonsson, G, Landsberg, J, Tuting, T and Holzel, M
  
• (2015) Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions; Cell 162, 1322-1337
  Eickhoff, S, Brewitz, A, Gerner, MY, Klauschen, F, Komander, K, Hemmi, H, Garbi, N, Kaisho, T, Germain, RN and Kastenmuller, W
  
• (2015) Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA; Nat Immunol 16, 1025-1033
  Herzner, AM, Hagmann, CA, Goldeck, M, Wolter, S, Kubler, K, Wittmann, S, Gramberg, T, Andreeva, L, Hopfner, KP, Mertens, C, Zillinger, T, Jin, T, Xiao, TS, Bartok, E, Coch, C, Ackermann, D, Hornung, V, Ludwig, J, Barchet, W, Hartmann, G and Schlee, M
  
• (2015) The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation; Nat Commun 6, 7088
  Kuhn, S, Erdmann, C, Kage, F, Block, J, Schwenkmezger, L, Steffen, A, Rottner, K and Geyer, M
  
• (2015) The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells; Immunity 42, 850-863
  Zehner, M, Marschall, AL, Bos, E, Schloetel, JG, Kreer, C, Fehrenschild, D, Limmer, A, Ossendorp, F, Lang, T, Koster, AJ, Dubel, S and Burgdorf, S
  
• (2016) Alzheimer’s disease risk variants modulate endophenotypes in mild cognitive impairment; Alzheimers Dement 12, 872-881
  Louwersheimer, E, Wolfsgruber, S, Espinosa, A, Lacour, A, Heilmann-Heimbach, S, Alegret, M, Hernandez, I, Rosende-Roca, M, Tarraga, L, Boada, M, Kornhuber, J, Peters, O, Frolich, L, Hull, M, Ruther, E, Wiltfang, J, Scherer, M, Riedel-Heller, S, Jessen, F, Nothen, MM, Maier, W, Koene, T, Scheltens, P, Holstege, H, Wagner, M, Ruiz, A, van der Flier, WM, Becker, T and Ramirez, A
  
• (2016) An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice; Kidney Int 90, 525-539
  Ludwig-Portugall, I, Bartok, E, Dhana, E, Evers, BD, Primiano, MJ, Hall, JP, Franklin, BS, Knolle, PA, Hornung, V, Hartmann, G, Boor, P, Latz, E and Kurts, C
  
• (2016) Anxiety, Stress, and Fear Response in Mice With Reduced Endocannabinoid Levels; Biol Psychiatry 79, 858-868
  Jenniches, I, Ternes, S, Albayram, O, Otte, DM, Bach, K, Bindila, L, Michel, K, Lutz, B, Bilkei-Gorzo, A and Zimmer, A
  
• (2016) Atopic dermatitis; Lancet 387, 1109-1122
  Weidinger, S and Novak, N
  
• (2016) Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain; Nat Commun 7, 12796
  Huckesfeld, S, Peters, M and Pankratz, MJ
  
• (2016) CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism; Nat Commun 7, 12338
  chmid-Burgk, JL, Honing, K, Ebert, TS and Hornung, V
  
• (2016) Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection; J Exp Med 213, 1409-1418
  Wilhelm, C, Harrison, OJ, Schmitt, V, Pelletier, M, Spencer, SP, Urban, JF, Jr., Ploch, M, Ramalingam, TR, Siegel, RM and Belkaid, Y
  
• (2016) Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming; Sci Transl Med 8, 333ra350
  Zimmer, S, Grebe, A, Bakke, SS, Bode, N, Halvorsen, B, Ulas, T, Skjelland, M, De Nardo, D, Labzin, LI, Kerksiek, A, Hempel, C, Heneka, MT, Hawxhurst, V, Fitzgerald, ML, Trebicka, J, Bjorkhem, I, Gustafsson, JA, Westerterp, M, Tall, AR, Wright, SD, Espevik, T, Schultze, JL, Nickenig, G, Lutjohann, D and Latz, E
  
• (2016) Discriminating self from non-self in nucleic acid sensing; Nat Rev Immunol 16, 566-580
  Schlee, M and Hartmann, G
  
• (2016) Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment; Sci Immunol 1, eaai7677
  Heidkamp, GF, Sander, J, Lehmann, CHK, Heger, L, Eissing, N, Baranska, A, Luhr, JJ, Hoffmann, A, Reimer, KC, Lux, A, Soder, S, Hartmann, A, Zenk, J, Ulas, T, McGovern, N, Alexiou, C, Spriewald, B, Mackensen, A, Schuler, G, Schauf, B, Forster, A, Repp, R, Fasching, PA, Purbojo, A, Cesnjevar, R, Ullrich, E, Ginhoux, F, Schlitzer, A, Nimmerjahn, F, Schultze, JL and Dudziak, D
  
• (2016) Human Monocytes Engage an Alternative Inflammasome Pathway; Immunity 44, 833-846
  Gaidt, MM, Ebert, TS, Chauhan, D, Schmidt, T, Schmid-Burgk, JL, Rapino, F, Robertson, AA, Cooper, MA, Graf, T and Hornung, V
  
• (2016) Inflammasome-Dependent Induction of Adaptive NK Cell Memory; Immunity 44, 1406-1421
  van den Boorn, JG, Jakobs, C, Hagen, C, Renn, M, Luiten, RM, Melief, CJ, Tuting, T, Garbi, N, Hartmann, G and Hornung, V
  
• (2016) Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4; Proc Natl Acad Sci USA 113, 10649-10654
  Schuette, V, Embgenbroich, M, Ulas, T, Welz, M, Schulte-Schrepping, J, Draffehn, AM, Quast, T, Koch, K, Nehring, M, Konig, J, Zweynert, A, Harms, FL, Steiner, N, Limmer, A, Forster, I, Berberich-Siebelt, F, Knolle, PA, Wohlleber, D, Kolanus, W, Beyer, M, Schultze, JL and Burgdorf, S
  
• (2016) Specification of tissue-resident macrophages during organogenesis; Science 353, eaaf4238
  Mass, E, Ballesteros, I, Farlik, M, Halbritter, F, Gunther, P, Crozet, L, Jacome-Galarza, CE, Handler, K, Klughammer, J, Kobayashi, Y, Gomez-Perdiguero, E, Schultze, JL, Beyer, M, Bock, C and Geissmann, F
  
• (2016) The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin; Cell Res 26, 151-170
  Schmidt, SV, Krebs, W, Ulas, T, Xue, J, Bassler, K, Gunther, P, Hardt, AL, Schultze, H, Sander, J, Klee, K, Theis, H, Kraut, M, Beyer, M and Schultze, JL
  
• (2016) Thoughts on Obesity and Brain Glucose; Cell 165, 773-775
  Heneka, MT and Nicotera, P
  
• (2016) Trained immunity: A program of innate immune memory in health and disease; Science 352, aaf1098
  Netea, MG, Joosten, LA, Latz, E, Mills, KH, Natoli, G, Stunnenberg, HG, O’Neill, LA and Xavier, RJ
  
• (2016) Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection; Nat Immunol 17, 593-603
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