EXC 1023:  ImmunoSensation: The Immune Sensory System

• Subject Area: Microbiology, Virology and Immunology
• Term: from 2012 to 2018
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 194445620

• Final Report Year: 2019

Final Report Abstract

The immune system plays a central role not only in health but also in the development of many diseases. With the innovative idea of investigating the immunosensory system, which includes the immune responses of immune and non-immune cells as well their interaction with the nervous system and metabolism. ImmunoSensation has become a leading center for immunological research, especially for innate immunity. Work at the Cluster has led to new ligands and signaling molecules, a new classification for macrophages, and important contributions to the understanding of the interaction between cancer and the immune system. Our scientists have characterized the negative influence of a western diet on the immune system and discovered a new therapeutic approach to reduce age-related memory decline. Two new biotech companies began as spin-offs, and two novel compounds are in clinical trials for tumor therapy. During the first funding period of the Cluster, international research collaborations with Melbourne and Osaka were formalized, and central research topics were developed into new Collaborative Research Centers. International recruitment was extremely important to the development of the immunological focus of ImmunoSensation. Since 2012, twelve new professorships for immunological research have been established at the University of Bonn, and professorships that were vacant in the field have been restaffed with leading immunologists. Morevoer, the German Center for Neurodegenerative Diseases (DZNE) has created two professorships in neuroinflammation. Over 20% of people recruited through the Cluster came from abroad. Early-career scientists with funding from the ERC, state (NRW), or DFG (Emmy Noether Programme) were successfully recruited to Bonn. ImmunoSensation has established two new master’s programs in English (Medical Immunosciences and Infection and Immunobiology) and the International Graduate School Immunosciences and Infection, central research platforms, and a central coordination office. Additionally, the development of new research buildings (BMZ II and LIMES-TIS) and new core facilities through the acquisition of new research equipment has also contributed to the development of scientific infrastructure. Several measures for family support have been implemented, such as the creation of two new family rooms and supplementary childcare services. Young female scientists were supported through specific project funding, coaching, and networking opportunities. 50% of newly appointed professorships were filled with women, and the proportion of female project leaders increased from 19% to 32% during the first funding period. Overall, ImmunoSensation has made a lasting contribution to understanding immunosensory processes and identifying new therapeutic approaches, especially through the establishment of support programs for young scientists and gender equality. Thus, ImmunoSensation’s central goal of establishing a leading national and international scientific center for immunology was achieved.

Link to the final report

https://dx.doi.org/10.2314/KXP:1697312306

Publications

• (2012) Melanomas resist T-cell therapy through inflammation-induced reversible dedifferentiation; Nature 490, 412-416
  Landsberg, J, Kohlmeyer, J, Renn, M, Bald, T, Rogava, M, Cron, M, Fatho, M, Lennerz, V, Wolfel, T, Holzel, M and Tuting, T
  
• (2013) A ligation-independent cloning technique for high-throughput assembly of transcription activator-like effector genes; Nat Biotechnol 31, 76-81
  Schmid-Burgk, JL, Schmidt, T, Kaiser, V, Honing, K and Hornung, V
  
• (2013) Activation and regulation of the inflammasomes; Nat Rev Immunol 13, 397-411
  Latz, E, Xiao, TS and Stutz, A
  
• (2013) Cell intrinsic immunity spreads to bystander cells via the intercellular transfer of cGAMP; Nature 503, 530-534
  Ablasser, A, Schmid-Burgk, JL, Hemmerling, I, Horvath, GL, Schmidt, T, Latz, E and Hornung, V
  
• (2013) cGAS produces a 2’-5’-linked cyclic dinucleotide second messenger that activates STING; Nature 498, 380-384
  Ablasser, A, Goldeck, M, Cavlar, T, Deimling, T, Witte, G, Rohl, I, Hopfner, KP, Ludwig, J and Hornung, V
  
• (2013) Cyclic [G(2’,5’)pA(3’,5’)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase; Cell 153, 1094-1107
  Gao, P, Ascano, M, Wu, Y, Barchet, W, Gaffney, BL, Zillinger, T, Serganov, AA, Liu, Y, Jones, RA, Hartmann, G, Tuschl, T and Patel, DJ
  
• (2013) Exclusive CX3CR1 dependence of kidney DCs impacts glomerulonephritis progression; J Clin Invest 123, 4242-4254
  Hochheiser, K, Heuser, C, Krause, TA, Teteris, S, Ilias, A, Weisheit, C, Hoss, F, Tittel, AP, Knolle, PA, Panzer, U, Engel, DR, Tharaux, PL and Kurts, C
  
• (2013) iGLuc: a luciferase-based inflammasome and protease activity reporter; Nat Methods 10, 147-154
  Bartok, E, Bauernfeind, F, Khaminets, MG, Jakobs, C, Monks, B, Fitzgerald, KA, Latz, E and Hornung, V
  
• (2013) Increased circulating levels of neurotrophins and elevated expression of their high-affinity receptors on skin and gut mast cells in mastocytosis; Blood 122, 1779-1788
  Peng, WM, Maintz, L, Allam, JP, Raap, U, Gutgemann, I, Kirfel, J, Wardelmann, E, Perner, S, Zhao, W, Fimmers, R, Walgenbach, K, Oldenburg, J, Schwartz, LB and Novak, N
  
• (2013) Intrahepatic myeloid-cell aggregates enable local proliferation of CD8(+) T cells and successful immunotherapy against chronic viral liver infection; Nat Immunol 14, 574-583
  Huang, LR, Wohlleber, D, Reisinger, F, Jenne, CN, Cheng, RL, Abdullah, Z, Schildberg, FA, Odenthal, M, Dienes, HP, van Rooijen, N, Schmitt, E, Garbi, N, Croft, M, Kurts, C, Kubes, P, Protzer, U, Heikenwalder, M and Knolle, PA
  
• (2013) Neutrophil swarms require LTB4 and integrins at sites of cell death in vivo; Nature 498, 371-375
  Lammermann, T, Afonso, PV, Angermann, BR, Wang, JM, Kastenmuller, W, Parent, CA and Germain, RN
  
• (2013) NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice; Nature 493, 674-678
  Heneka, MT, Kummer, MP, Stutz, A, Delekate, A, Schwartz, S, Vieira-Saecker, A, Griep, A, Axt, D, Remus, A, Tzeng, TC, Gelpi, E, Halle, A, Korte, M, Latz, E and Golenbock, DT
  
• (2013) Oxidative damage of DNA confers resistance to cytosolic nuclease TREX1 degradation and potentiates STING-dependent immune sensing; Immunity 39, 482-495
  Gehrke, N, Mertens, C, Zillinger, T, Wenzel, J, Bald, T, Zahn, S, Tuting, T, Hartmann, G and Barchet, W
  
• (2013) Plasticity of tumour and immune cells: a source of heterogeneity and a cause for therapy resistance?; Nat Rev Cancer 13, 365-376
  Hölzel, M, Bovier, A and Tüting, T
  
• (2013) RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA; J Exp Med 210, 2447-2463
  Sirois, CM, Jin, T, Miller, AL, Bertheloot, D, Nakamura, H, Horvath, GL, Mian, A, Jiang, J, Schrum, J, Bossaller, L, Pelka, K, Garbi, N, Brewah, Y, Tian, J, Chang, C, Chowdhury, PS, Sims, GP, Kolbeck, R, Coyle, AJ, Humbles, AA, Xiao, TS and Latz, E
  
• (2013) Species-specific detection of the antiviral small-molecule compound CMA by STING; EMBO J 32, 1440-1450
  Cavlar, T, Deimling, T, Ablasser, A, Hopfner, KP and Hornung, V
  
• (2013) Structure-function analysis of STING activation by c[G(2’,5’)pA(3’,5’)p] and targeting by antiviral DMXAA; Cell 154, 748-762
  Gao, P, Ascano, M, Zillinger, T, Wang, W, Dai, P, Serganov, AA, Gaffney, BL, Shuman, S, Jones, RA, Deng, L, Hartmann, G, Barchet, W, Tuschl, T and Patel, DJ
  
• (2013) The immune system and kidney disease: basic concepts and clinical implications; Nat Rev Immunol 13, 738-753
  Kurts, C, Panzer, U, Anders, HJ and Rees, AJ
  
• (2013) Turning tumors into vaccines: co-opting the innate immune system; Immunity 39, 27-37
  van den Boorn, JG and Hartmann, G
  
• (2014) Antiviral immunity via RIG-I-mediated recognition of RNA bearing 5’-diphosphates; Nature 514, 372-375
  Goubau, D, Schlee, M, Deddouche, S, Pruijssers, AJ, Zillinger, T, Goldeck, M, Schuberth, C, Van der Veen, AG, Fujimura, T, Rehwinkel, J, Iskarpatyoti, JA, Barchet, W, Ludwig, J, Dermody, TS, Hartmann, G and Reis e Sousa, C
  
• (2014) Characterizing the genetic basis of innate immune response in TLR4-activated human monocytes; Nat Commun 5, 5236
  Kim, S, Becker, J, Bechheim, M, Kaiser, V, Noursadeghi, M, Fricker, N, Beier, E, Klaschik, S, Boor, P, Hess, T, Hofmann, A, Holdenrieder, S, Wendland, JR, Frohlich, H, Hartmann, G, Nothen, MM, Muller-Myhsok, B, Putz, B, Hornung, V and Schumacher, J
  
• (2014) Crosstalk between sentinel and helper macrophages permits neutrophil migration into infected uroepithelium; Cell 156, 456-468
  Schiwon, M, Weisheit, C, Franken, L, Gutweiler, S, Dixit, A, Meyer-Schwesinger, C, Pohl, JM, Maurice, NJ, Thiebes, S, Lorenz, K, Quast, T, Fuhrmann, M, Baumgarten, G, Lohse, MJ, Opdenakker, G, Bernhagen, J, Bucala, R, Panzer, U, Kolanus, W, Grone, HJ, Garbi, N, Kastenmuller, W, Knolle, PA, Kurts, C and Engel, DR
  
• (2014) Cytosolic RNA:DNA hybrids activate the cGAS-STING axis; EMBO J 33, 2937-2946
  Mankan, AK, Schmidt, T, Chauhan, D, Goldeck, M, Honing, K, Gaidt, M, Kubarenko, AV, Andreeva, L, Hopfner, KP and Hornung, V
  
• (2014) Dendritic cell-targeted vaccines-- hope or hype?; Nat Rev Immunol 14, 705-711
  Kastenmuller, W, Kastenmuller, K, Kurts, C and Seder, RA
  
• (2014) Efficient genome engineering by targeted homologous recombination in mouse embryos using transcription activator-like effector nucleases; Nat Commun 5, 3045
  Sommer, D, Peters, A, Wirtz, T, Mai, M, Ackermann, J, Thabet, Y, Schmidt, J, Weighardt, H, Wunderlich, FT, Degen, J, Schultze, JL and Beyer, M
  
• (2014) Efficient solid-phase synthesis of pppR- NA by using product-specific labeling; Angew Chem Int Ed Engl 53, 4694-4698
  Goldeck, M, Tuschl, T, Hartmann, G and Ludwig, J
  
• (2014) High-density lipoprotein mediates anti-inflammatory reprogramming of macrophages via the transcriptional regulator ATF3; Nat Immunol 15, 152-160
  De Nardo, D, Labzin, LI, Kono, H, Seki, R, Schmidt, SV, Beyer, M, Xu, D, Zimmer, S, Lahrmann, C, Schildberg, FA, Vogelhuber, J, Kraut, M, Ulas, T, Kerksiek, A, Krebs, W, Bode, N, Grebe, A, Fitzgerald, ML, Hernandez, NJ, Williams, BR, Knolle, P, Kneilling, M, Rocken, M, Lutjohann, D, Wright, SD, Schultze, JL and Latz, E
  
• (2014) Immune cell-poor melanomas benefit from PD-1 blockade after targeted type I IFN activation; Cancer Discov 4, 674-687
  Bald, T, Landsberg, J, Lopez-Ramos, D, Renn, M, Glodde, N, Jansen, P, Gaffal, E, Steitz, J, Tolba, R, Kalinke, U, Limmer, A, Jonsson, G, Holzel, M and Tuting, T
  
• (2014) Innate immune activation in neurodegenerative disease; Nat Rev Immunol 14, 463-477
  Heneka, MT, Kummer, MP and Latz, E
  
• (2014) OAS proteins and cGAS: unifying concepts in sensing and responding to cytosolic nucleic acids; Nat Rev Immunol 14, 521-528
  Hornung, V, Hartmann, R, Ablasser, A and Hopfner, KP
  
• (2014) Selection of motor programs for suppressing food intake and inducing locomotion in the Drosophila brain; PLoS Biol 12, e1001893
  Schoofs, A, Huckesfeld, S, Schlegel, P, Miroschnikow, A, Peters, M, Zeymer, M, Spiess, R, Chiang, AS and Pankratz, MJ
  
• (2014) The adaptor ASC has extracellular and ‘prionoid’ activities that propagate inflammation; Nat Immunol 15, 727-737
  Franklin, BS, Bossaller, L, De Nardo, D, Ratter, JM, Stutz, A, Engels, G, Brenker, C, Nordhoff, M, Mirandola, SR, Al-Amoudi, A, Mangan, MS, Zimmer, S, Monks, BG, Fricke, M, Schmidt, RE, Espevik, T, Jones, B, Jarnicki, AG, Hansbro, PM, Busto, P, Marshak-Rothstein, A, Hornemann, S, Aguzzi, A, Kastenmuller, W and Latz, E
  
• (2014) Transcriptome-based network analysis reveals a spectrum model of human macrophage activation; Immunity 40, 274-288
  Xue, J, Schmidt, SV, Sander, J, Draffehn, A, Krebs, W, Quester, I, De Nardo, D, Gohel, TD, Emde, M, Schmidleithner, L, Ganesan, H, Nino-Castro, A, Mallmann, MR, Labzin, L, Theis, H, Kraut, M, Beyer, M, Latz, E, Freeman, TC, Ulas, T and Schultze, JL
  
• (2014) Ultraviolet-radiation-induced inflammation promotes angiotropism and metastasis in melanoma; Nature 507, 109-113
  Bald, T, Quast, T, Landsberg, J, Rogava, M, Glodde, N, Lopez-Ramos, D, Kohlmeyer, J, Riesenberg, S, van den Boorn-Konijnenberg, D, Homig-Holzel, C, Reuten, R, Schadow, B, Weighardt, H, Wenzel, D, Helfrich, I, Schadendorf, D, Bloch, W, Bianchi, ME, Lugassy, C, Barnhill, RL, Koch, M, Fleischmann, BK, Forster, I, Kastenmuller, W, Kolanus, W, Holzel, M, Gaffal, E and Tuting, T
  
• (2015) A Conserved Histidine in the RNA Sensor RIG-I Controls Immune Tolerance to N1-2’O-Methylated Self RNA; Immunity 43, 41-51
  Schuberth-Wagner, C, Ludwig, J, Bruder, AK, Herzner, AM, Zillinger, T, Goldeck, M, Schmidt, T, Schmid-Burgk, JL, Kerber, R, Wolter, S, Stumpel, JP, Roth, A, Bartok, E, Drosten, C, Coch, C, Hornung, V, Barchet, W, Kummerer, BM, Hartmann, G and Schlee, M
  
• (2015) A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases; Nat Med 21, 248-255
  Coll, RC, Robertson, AA, Chae, JJ, Higgins, SC, Munoz-Planillo, R, Inserra, MC, Vetter, I, Dungan, LS, Monks, BG, Stutz, A, Croker, DE, Butler, MS, Haneklaus, M, Sutton, CE, Nunez, G, Latz, E, Kastner, DL, Mills, KH, Masters, SL, Schroder, K, Cooper, MA and O’Neill, LA
  
• (2015) CXCR3 promotes plaque formation and behavioral deficits in an Alzheimer’s disease model; J Clin Invest 125, 365-378
  Krauthausen, M, Kummer, MP, Zimmermann, J, Reyes-Irisarri, E, Terwel, D, Bulic, B, Heneka, MT and Muller, M
  
• (2015) Doxycycline Leads to Sterility and Enhanced Killing of Female Onchocerca volvulus Worms in an Area With Persistent Microfilaridermia After Repeated Ivermectin Treatment: A Randomized, Placebo-Controlled, Double-Blind Trial; Clin Infect Dis 61, 517-526
  Debrah, AY, Specht, S, Klarmann-Schulz, U, Batsa, L, Mand, S, Marfo-Debrekyei, Y, Fimmers, R, Dubben, B, Kwarteng, A, Osei-Atweneboana, M, Boakye, D, Ricchiuto, A, Buttner, M, Adjei, O, Mackenzie, CD and Hoerauf, A
  
• (2015) Endocannabinoid signalling and the deteriorating brain; Nat Rev Neurosci 16, 30-42
  Di Marzo, V, Stella, N and Zimmer, A
  
• (2015) Functional classification of memory CD8(+) T cells by CX3CR1 expression; Nat Commun 6, 8306
  Bottcher, JP, Beyer, M, Meissner, F, Abdullah, Z, Sander, J, Hochst, B, Eickhoff, S, Rieckmann, JC, Russo, C, Bauer, T, Flecken, T, Giesen, D, Engel, D, Jung, S, Busch, DH, Protzer, U, Thimme, R, Mann, M, Kurts, C, Schultze, JL, Kastenmuller, W and Knolle, PA
  
• (2015) Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci; Nat Commun 6, 5966
  Betz, RC, Petukhova, L, Ripke, S, Huang, H, Menelaou, A, Redler, S, Becker, T, Heilmann, S, Yamany, T, Duvic, M, Hordinsky, M, Norris, D, Price, VH, Mackay-Wiggan, J, de Jong, A, DeStefano, GM, Moebus, S, Bohm, M, Blume-Peytavi, U, Wolff, H, Lutz, G, Kruse, R, Bian, L, Amos, CI, Lee, A, Gregersen, PK, Blaumeiser, B, Altshuler, D, Clynes, R, de Bakker, PIW, Noethen, MM, Daly, MJ and Christiano, AM
  
• (2015) Innate immunity in Alzheimer’s disease; Nat Immunol 16, 229-236
  Heneka, MT, Golenbock, DT and Latz, E
  
• (2015) MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment; Nat Commun 6, 8755
  Riesenberg, S, Groetchen, A, Siddaway, R, Bald, T, Reinhardt, J, Smorra, D, Kohlmeyer, J, Renn, M, Phung, B, Aymans, P, Schmidt, T, Hornung, V, Davidson, I, Goding, CR, Jonsson, G, Landsberg, J, Tuting, T and Holzel, M
  
• (2015) Robust Anti-viral Immunity Requires Multiple Distinct T Cell-Dendritic Cell Interactions; Cell 162, 1322-1337
  Eickhoff, S, Brewitz, A, Gerner, MY, Klauschen, F, Komander, K, Hemmi, H, Garbi, N, Kaisho, T, Germain, RN and Kastenmuller, W
  
• (2015) Sequence-specific activation of the DNA sensor cGAS by Y-form DNA structures as found in primary HIV-1 cDNA; Nat Immunol 16, 1025-1033
  Herzner, AM, Hagmann, CA, Goldeck, M, Wolter, S, Kubler, K, Wittmann, S, Gramberg, T, Andreeva, L, Hopfner, KP, Mertens, C, Zillinger, T, Jin, T, Xiao, TS, Bartok, E, Coch, C, Ackermann, D, Hornung, V, Ludwig, J, Barchet, W, Hartmann, G and Schlee, M
  
• (2015) The structure of FMNL2-Cdc42 yields insights into the mechanism of lamellipodia and filopodia formation; Nat Commun 6, 7088
  Kuhn, S, Erdmann, C, Kage, F, Block, J, Schwenkmezger, L, Steffen, A, Rottner, K and Geyer, M
  
• (2015) The translocon protein Sec61 mediates antigen transport from endosomes in the cytosol for cross-presentation to CD8(+) T cells; Immunity 42, 850-863
  Zehner, M, Marschall, AL, Bos, E, Schloetel, JG, Kreer, C, Fehrenschild, D, Limmer, A, Ossendorp, F, Lang, T, Koster, AJ, Dubel, S and Burgdorf, S
  
• (2016) Alzheimer’s disease risk variants modulate endophenotypes in mild cognitive impairment; Alzheimers Dement 12, 872-881
  Louwersheimer, E, Wolfsgruber, S, Espinosa, A, Lacour, A, Heilmann-Heimbach, S, Alegret, M, Hernandez, I, Rosende-Roca, M, Tarraga, L, Boada, M, Kornhuber, J, Peters, O, Frolich, L, Hull, M, Ruther, E, Wiltfang, J, Scherer, M, Riedel-Heller, S, Jessen, F, Nothen, MM, Maier, W, Koene, T, Scheltens, P, Holstege, H, Wagner, M, Ruiz, A, van der Flier, WM, Becker, T and Ramirez, A
  
• (2016) An NLRP3-specific inflammasome inhibitor attenuates crystal-induced kidney fibrosis in mice; Kidney Int 90, 525-539
  Ludwig-Portugall, I, Bartok, E, Dhana, E, Evers, BD, Primiano, MJ, Hall, JP, Franklin, BS, Knolle, PA, Hornung, V, Hartmann, G, Boor, P, Latz, E and Kurts, C
  
• (2016) Anxiety, Stress, and Fear Response in Mice With Reduced Endocannabinoid Levels; Biol Psychiatry 79, 858-868
  Jenniches, I, Ternes, S, Albayram, O, Otte, DM, Bach, K, Bindila, L, Michel, K, Lutz, B, Bilkei-Gorzo, A and Zimmer, A
  
• (2016) Atopic dermatitis; Lancet 387, 1109-1122
  Weidinger, S and Novak, N
  
• (2016) Central relay of bitter taste to the protocerebrum by peptidergic interneurons in the Drosophila brain; Nat Commun 7, 12796
  Huckesfeld, S, Peters, M and Pankratz, MJ
  
• (2016) CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism; Nat Commun 7, 12338
  chmid-Burgk, JL, Honing, K, Ebert, TS and Hornung, V
  
• (2016) Critical role of fatty acid metabolism in ILC2-mediated barrier protection during malnutrition and helminth infection; J Exp Med 213, 1409-1418
  Wilhelm, C, Harrison, OJ, Schmitt, V, Pelletier, M, Spencer, SP, Urban, JF, Jr., Ploch, M, Ramalingam, TR, Siegel, RM and Belkaid, Y
  
• (2016) Cyclodextrin promotes atherosclerosis regression via macrophage reprogramming; Sci Transl Med 8, 333ra350
  Zimmer, S, Grebe, A, Bakke, SS, Bode, N, Halvorsen, B, Ulas, T, Skjelland, M, De Nardo, D, Labzin, LI, Kerksiek, A, Hempel, C, Heneka, MT, Hawxhurst, V, Fitzgerald, ML, Trebicka, J, Bjorkhem, I, Gustafsson, JA, Westerterp, M, Tall, AR, Wright, SD, Espevik, T, Schultze, JL, Nickenig, G, Lutjohann, D and Latz, E
  
• (2016) Discriminating self from non-self in nucleic acid sensing; Nat Rev Immunol 16, 566-580
  Schlee, M and Hartmann, G
  
• (2016) Human lymphoid organ dendritic cell identity is predominantly dictated by ontogeny, not tissue microenvironment; Sci Immunol 1, eaai7677
  Heidkamp, GF, Sander, J, Lehmann, CHK, Heger, L, Eissing, N, Baranska, A, Luhr, JJ, Hoffmann, A, Reimer, KC, Lux, A, Soder, S, Hartmann, A, Zenk, J, Ulas, T, McGovern, N, Alexiou, C, Spriewald, B, Mackensen, A, Schuler, G, Schauf, B, Forster, A, Repp, R, Fasching, PA, Purbojo, A, Cesnjevar, R, Ullrich, E, Ginhoux, F, Schlitzer, A, Nimmerjahn, F, Schultze, JL and Dudziak, D
  
• (2016) Human Monocytes Engage an Alternative Inflammasome Pathway; Immunity 44, 833-846
  Gaidt, MM, Ebert, TS, Chauhan, D, Schmidt, T, Schmid-Burgk, JL, Rapino, F, Robertson, AA, Cooper, MA, Graf, T and Hornung, V
  
• (2016) Inflammasome-Dependent Induction of Adaptive NK Cell Memory; Immunity 44, 1406-1421
  van den Boorn, JG, Jakobs, C, Hagen, C, Renn, M, Luiten, RM, Melief, CJ, Tuting, T, Garbi, N, Hartmann, G and Hornung, V
  
• (2016) Mannose receptor induces T-cell tolerance via inhibition of CD45 and up-regulation of CTLA-4; Proc Natl Acad Sci USA 113, 10649-10654
  Schuette, V, Embgenbroich, M, Ulas, T, Welz, M, Schulte-Schrepping, J, Draffehn, AM, Quast, T, Koch, K, Nehring, M, Konig, J, Zweynert, A, Harms, FL, Steiner, N, Limmer, A, Forster, I, Berberich-Siebelt, F, Knolle, PA, Wohlleber, D, Kolanus, W, Beyer, M, Schultze, JL and Burgdorf, S
  
• (2016) Specification of tissue-resident macrophages during organogenesis; Science 353, eaaf4238
  Mass, E, Ballesteros, I, Farlik, M, Halbritter, F, Gunther, P, Crozet, L, Jacome-Galarza, CE, Handler, K, Klughammer, J, Kobayashi, Y, Gomez-Perdiguero, E, Schultze, JL, Beyer, M, Bock, C and Geissmann, F
  
• (2016) The transcriptional regulator network of human inflammatory macrophages is defined by open chromatin; Cell Res 26, 151-170
  Schmidt, SV, Krebs, W, Ulas, T, Xue, J, Bassler, K, Gunther, P, Hardt, AL, Schultze, H, Sander, J, Klee, K, Theis, H, Kraut, M, Beyer, M and Schultze, JL
  
• (2016) Thoughts on Obesity and Brain Glucose; Cell 165, 773-775
  Heneka, MT and Nicotera, P
  
• (2016) Trained immunity: A program of innate immune memory in health and disease; Science 352, aaf1098
  Netea, MG, Joosten, LA, Latz, E, Mills, KH, Natoli, G, Stunnenberg, HG, O’Neill, LA and Xavier, RJ
  
• (2016) Tumor-necrosis factor impairs CD4(+) T cell-mediated immunological control in chronic viral infection; Nat Immunol 17, 593-603
  Beyer, M, Abdullah, Z, Chemnitz, JM, Maisel, D, Sander, J, Lehmann, C, Thabet, Y, Shinde, PV, Schmidleithner, L, Kohne, M, Trebicka, J, Schierwagen, R, Hofmann, A, Popov, A, Lang, KS, Oxenius, A, Buch, T, Kurts, C, Heikenwalder, M, Fatkenheuer, G, Lang, PA, Hartmann, P, Knolle, PA and Schultze, JL
  
• (2017) A chronic low dose of Del- ta(9)-tetrahydrocannabinol (THC) restores cognitive function in old mice; Nat Med 23, 782-787
  Bilkei-Gorzo, A, Albayram, O, Draffehn, A, Michel, K, Piyanova, A, Oppenheimer, H, Dvir-Ginzberg, M, Racz, I, Ulas, T, Imbeault, S, Bab, I, Schultze, JL and Zimmer, A
  
• (2017) CD8(+) T Cells Orchestrate pDC-XCR1(+) Dendritic Cell Spatial and Functional Cooperativity to Optimize Priming; Immunity 46, 205-219
  Brewitz, A, Eickhoff, S, Dahling, S, Quast, T, Bedoui, S, Kroczek, RA, Kurts, C, Garbi, N, Barchet, W, Iannacone, M, Klauschen, F, Kolanus, W, Kaisho, T, Colonna, M, Germain, RN and Kastenmuller, W
  
• (2017) Cellular Differentiation of Human Monocytes Is Regulated by Time-Dependent Interleukin-4 Signaling and the Transcriptional Regulator NCOR2; Immunity 47, 1051-1066 e1012
  Sander, J, Schmidt, SV, Cirovic, B, McGovern, N, Papantonopoulou, O, Hardt, AL, Aschenbrenner, AC, Kreer, C, Quast, T, Xu, AM, Schmidleithner, LM, Theis, H, Thi Huong, LD, Sumatoh, HRB, Lauterbach, MAR, Schulte-Schrepping, J, Gunther, P, Xue, J, Bassler, K, Ulas, T, Klee, K, Katzmarski, N, Herresthal, S, Krebs, W, Martin, B, Latz, E, Handler, K, Kraut, M, Kolanus, W, Beyer, M, Falk, CS, Wiegmann, B, Burgdorf, S, Melosh, NA, Newell, EW, Ginhoux, F, Schlitzer, A and Schultze, JL
  
• (2017) Endocytic sorting motif interactions involved in Nef-mediated downmodulation of CD4 and CD3; Nat Commun 8, 442
  Manrique, S, Sauter, D, Horenkamp, FA, Lulf, S, Yu, H, Hotter, D, Anand, K, Kirchhoff, F and Geyer, M
  
• (2017) Genetic regulatory effects modified by immune activation contribute to autoimmune disease associations; Nat Commun 8, 266
  Kim-Hellmuth, S, Bechheim, M, Putz, B, Mohammadi, P, Nedelec, Y, Giangreco, N, Becker, J, Kaiser, V, Fricker, N, Beier, E, Boor, P, Castel, SE, Nothen, MM, Barreiro, LB, Pickrell, JK, Muller-Myhsok, B, Lappalainen, T, Schumacher, J and Hornung, V
  
• (2017) Genome-wide significant risk factors for Alzheimer’s disease: role in progression to dementia due to Alzheimer’s disease among subjects with mild cognitive impairment; Mol Psychiatry 22, 153-160
  Lacour, A, Espinosa, A, Louwersheimer, E, Heilmann, S, Hernandez, I, Wolfsgruber, S, Fernandez, V, Wagner, H, Rosende-Roca, M, Mauleon, A, Moreno-Grau, S, Vargas, L, Pijnenburg, YA, Koene, T, Rodriguez-Gomez, O, Ortega, G, Ruiz, S, Holstege, H, Sotolongo-Grau, O, Kornhuber, J, Peters, O, Frolich, L, Hull, M, Ruther, E, Wiltfang, J, Scherer, M, Riedel-Heller, S, Alegret, M, Nothen, MM, Scheltens, P, Wagner, M, Tarraga, L, Jessen, F, Boada, M, Maier, W, van der Flier, WM, Becker, T, Ramirez, A and Ruiz, A
  
• (2017) Gut microbial translocation corrupts myeloid cell function to control bacterial infection during liver cirrhosis; Gut 66, 507-518
  Hackstein, CP, Assmus, LM, Welz, M, Klein, S, Schwandt, T, Schultze, J, Forster, I, Gondorf, F, Beyer, M, Kroy, D, Kurts, C, Trebicka, J, Kastenmuller, W, Knolle, PA and Abdullah, Z
  
• (2017) Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing; Nature 550, 119-123
  Camell, CD, Sander, J, Spadaro, O, Lee, A, Nguyen, KY, Wing, A, Goldberg, EL, Youm, YH, Brown, CW, Elsworth, J, Rodeheffer, MS, Schultze, JL and Dixit, VD
  
• (2017) Irf4-dependent CD103(+)CD11b(+) dendritic cells and the intestinal microbiome regulate monocyte and macrophage activation and intestinal peristalsis in postoperative ileus; Gut 66, 2110-2120
  Pohl, JM, Gutweiler, S, Thiebes, S, Volke, JK, Klein-Hitpass, L, Zwanziger, D, Gunzer, M, Jung, S, Agace, WW, Kurts, C and Engel, DR
  
• (2017) Liver sinusoidal endothelial cell cross-priming is supported by CD4 T cell-derived IL-2; J Hepatol 66, 978-986
  Wittlich, M, Dudek, M, Bottcher, JP, Schanz, O, Hegenbarth, S, Bopp, T, Schmitt, E, Kurts, C, Garbers, C, Rose John, S, Knolle, PA and Wohlleber, D
  
• (2017) Mapping the human DC lineage through the integration of high-dimensional techniques; Science 356, eaag3009
  See, P, Dutertre, CA, Chen, J, Gunther, P, McGovern, N, Irac, SE, Gunawan, M, Beyer, M, Handler, K, Duan, K, Sumatoh, HRB, Ruffin, N, Jouve, M, Gea-Mallorqui, E, Hennekam, RCM, Lim, T, Yip, CC, Wen, M, Malleret, B, Low, I, Shadan, NB, Fen, CFS, Tay, A, Lum, J, Zolezzi, F, Larbi, A, Poidinger, M, Chan, JKY, Chen, Q, Renia, L, Haniffa, M, Benaroch, P, Schlitzer, A, Schultze, JL, Newell, EW and Ginhoux, F
  
• (2017) Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness; Nat Commun 8, 14694
  Heilmann-Heimbach, S, Herold, C, Hochfeld, LM, Hillmer, AM, Nyholt, DR, Hecker, J, Javed, A, Chew, EG, Pechlivanis, S, Drichel, D, Heng, XT, Del Rosario, RC, Fier, HL, Paus, R, Rueedi, R, Galesloot, TE, Moebus, S, Anhalt, T, Prabhakar, S, Li, R, Kanoni, S, Papanikolaou, G, Kutalik, Z, Deloukas, P, Philpott, MP, Waeber, G, Spector, TD, Vollenweider, P, Kiemeney, LA, Dedoussis, G, Richards, JB, Nothnagel, M, Martin, NG, Becker, T, Hinds, DA and Nothen, MM
  
• (2017) Microglia-derived ASC specks cross-seed amyloid-beta in Alzheimer’s disease; Nature 552, 355-361
  Venegas, C, Kumar, S, Franklin, BS, Dierkes, T, Brinkschulte, R, Tejera, D, Vieira-Saecker, A, Schwartz, S, Santarelli, F, Kummer, MP, Griep, A, Gelpi, E, Beilharz, M, Riedel, D, Golenbock, DT, Geyer, M, Walter, J, Latz, E and Heneka, MT
  
• (2017) Mutations in gamma-secretase subunit-encoding PSENEN underlie Dowling-Degos disease associated with acne inversa; J Clin Invest 127, 1485-1490
  Ralser, DJ, Basmanav, FB, Tafazzoli, A, Wititsuwannakul, J, Delker, S, Danda, S, Thiele, H, Wolf, S, Busch, M, Pulimood, SA, Altmuller, J, Nurnberg, P, Lacombe, D, Hillen, U, Wenzel, J, Frank, J, Odermatt, B and Betz, RC
  
• (2017) NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain; J Exp Med 214, 1725-1736
  Stutz, A, Kolbe, CC, Stahl, R, Horvath, GL, Franklin, BS, van Ray, O, Brinkschulte, R, Geyer, M, Meissner, F and Latz, E
  
• (2017) Polysialic acid blocks mononuclear phagocyte reactivity, inhibits complement activation, and protects from vascular damage in the retina; EMBO Mol Med 9, 154-166
  Karlstetter, M, Kopatz, J, Aslanidis, A, Shahraz, A, Caramoy, A, Linnartz-Gerlach, B, Lin, Y, Luckoff, A, Fauser, S, Duker, K, Claude, J, Wang, Y, Ackermann, J, Schmidt, T, Hornung, V, Skerka, C, Langmann, T and Neumann, H
  
• (2017) Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer’s disease; Nat Genet 49, 1373-1384
  Sims, R ..., Nothen, MM ..., Schellenberg, GD
  
• (2017) Reactive Neutrophil Responses Dependent on the Receptor Tyrosine Kinase c-MET Limit Cancer Immunotherapy; Immunity 47, 789- 802, e789
  Glodde, N, Bald, T, van den Boorn-Konijnenberg, D, Nakamura, K, O’Donnell, JS, Szczepanski, S, Brandes, M, Eickhoff, S, Das, I, Shridhar, N, Hinze, D, Rogava, M, van der Sluis, TC, Ruotsalainen, JJ, Gaffal, E, Landsberg, J, Ludwig, KU, Wilhelm, C, Riek-Burchardt, M, Muller, AJ, Gebhardt, C, Scolyer, RA, Long, GV, Janzen, V, Teng, MWL, Kasten- muller, W, Mazzone, M, Smyth, MJ, Tuting, T and Holzel, M
  
• (2017) RIG-I Resists Hypoxia-Induced Immunosuppression and Dedifferentiation; Cancer Immunol Res 5, 455-467
  Engel, C, Brugmann, G, Lambing, S, Muhlenbeck, LH, Marx, S, Hagen, C, Horvath, D, Goldeck, M, Ludwig, J, Herzner, AM, Drijfhout, JW, Wenzel, D, Coch, C, Tuting, T, Schlee, M, Hornung, V, Hartmann, G and Van den Boorn, JG
  
• (2017) S100-alarmin-induced innate immune programming protects newborn infants from sepsis; Nat Immunol 18, 622-632
  Ulas, T, Pirr, S, Fehlhaber, B, Bickes, MS, Loof, TG, Vogl, T, Mellinger, L, Heinemann, AS, Burgmann, J, Schoning, J, Schreek, S, Pfeifer, S, Reuner, F, Vollger, L, Stanulla, M, von Kockritz-Blickwede, M, Glander, S, Barczyk-Kahlert, K, von Kaisenberg, CS, Friesenhagen, J, Fischer-Riepe, L, Zenker, S, Schultze, JL, Roth, J and Viemann, D
  
• (2018) In Vivo Labeling by CD73 Marks Multipotent Stromal Cells and Highlights Endothelial Heterogeneity in the Bone Marrow Niche; Cell Stem Cell 22, 262-276 e267
  Breitbach, M, Kimura, K, Luis, TC, Fuegemann, CJ, Woll, PS, Hesse, M, Facchini, R, Rieck, S, Jobin, K, Reinhardt, J, Ohneda, O, Wenzel, D, Geisen, C, Kurts, C, Kastenmuller, W, Holzel, M, Jacobsen, SEW and Fleischmann, BK
  
• (2018) Inflammasome signalling in brain function and neurodegenerative disease; Nat Rev Neurosci 19, 610-621
  Heneka, MT, McManus, RM and Latz, E
  
• (2018) Innate immune memory in the brain shapes neurological disease hallmarks; Nature 556, 332-338
  Wendeln, AC, Degenhardt, K, Kaurani, L, Gertig, M, Ulas, T, Jain, G, Wagner, J, Hasler, LM, Wild, K, Skodras, A, Blank, T, Staszewski, O, Datta, M, Centeno, TP, Capece, V, Islam, MR, Kerimoglu, C, Staufenbiel, M, Schultze, JL, Beyer, M, Prinz, M, Jucker, M, Fischer, A and Neher, JJ
  
• (2018) Microbiome Influences Prenatal and Adult Microglia in a Sex-Specific Manner; Cell 172, 500- 516 e516
  Thion, MS, Low, D, Silvin, A, Chen, J, Grisel, P, Schulte-Schrepping, J, Blecher, R, Ulas, T, Squarzoni, P, Hoeffel, G, Coulpier, F, Siopi, E, David, FS, Scholz, C, Shihui, F, Lum, J, Amoyo, AA, Larbi, A, Poidinger, M, Buttgereit, A, Lledo, PM, Greter, M, Chan, JKY, Amit, I, Beyer, M, Schultze, JL, Schlitzer, A, Pettersson, S, Ginhoux, F and Garel, S
  
• (2018) Modulation of Myelopoiesis Progenitors Is an Integral Component of Trained Immunity; Cell 172, 147-161 e112
  Mitroulis, I, Ruppova, K, Wang, B, Chen, LS, Grzybek, M, Grinenko, T, Eugster, A, Troullinaki, M, Palladini, A, Kourtzelis, I, Chatzigeorgiou, A, Schlitzer, A, Beyer, M, Joosten, LAB, Isermann, B, Lesche, M, Petzold, A, Simons, K, Henry, I, Dahl, A, Schultze, JL, Wielockx, B, Zamboni, N, Mirtschink, P, Coskun, U, Hajishengallis, G, Netea, MG and Chavakis, T
  
• (2018) Perforin inhibition protects from lethal endothelial damage during fulminant viral hepatitis; Nat Commun 9, 4805
  Welz, M, Eickhoff, S, Abdullah, Z, Trebicka, J, Gartlan, KH, Spicer, JA, Demetris, AJ, Akhlaghi, H, Anton, M, Manske, K, Zehn, D, Nieswandt, B, Kurts, C, Trapani, JA, Knolle, P, Wohlleber, D and Kastenmuller, W
  
• (2018) Rescue of T-cell function during persistent pulmonary adenoviral infection by Toll-like receptor 9 activation; J Allergy Clin Immunol 141, 416-419, e410
  Holland, T, Wohlleber, D, Marx, S, Kreutzberg, T, Vento-Asturias, S, Schmitt-Mbamunyo, C, Welz, M, Janas, M, Komander, K, Eickhoff, S, Brewitz, A, Hasenberg, M, Mann, L, Gunzer, M, Wilhelm, C, Kastenmuller, W, Knolle, P, Abdullah, Z, Kurts, C and Garbi, N
  
• (2018) RNA Aptamers Recognizing Murine CCL17 Inhibit T Cell Chemotaxis and Reduce Contact Hypersensitivity In Vivo; Mol Ther 26, 95-104
  Fulle, L, Steiner, N, Funke, M, Gondorf, F, Pfeiffer, F Siegl, J, Opitz, FV, Hassel, SK, Erazo, AB, Schanz, O, Stunden, HJ, Blank, M, Grober, C, Handler, K, Beyer, M, Weighardt, H, Latz, E, Schultze, JL, Mayer, G and Forster, I
  
• (2018) The Chaperone UNC93B1 Regulates Tolllike Receptor Stability Independently of Endosomal TLR Transport; Immunity 48, 911-922 e917
  Pelka, K, Bertheloot, D, Reimer, E, Phulphagar, K, Schmidt, SV, Christ, A, Stahl, R, Watson, N, Miyake, K, Hacohen, N, Haas, A, Brinkmann, MM, Marshak-Rothstein, A, Meissner, F and Latz, E
  
• (2018) Western Diet Triggers NLRP3-Dependent Innate Immune Reprogramming; Cell 172, 162-175 e114
  Christ, A, Gunther, P, Lauterbach, MAR, Duewell, P, Biswas, D, Pelka, K, Scholz, CJ, Oosting, M, Haendler, K, Bassler, K, Klee, K, Schulte-Schrepping, J, Ulas, T, Moorlag, S, Kumar, V, Park, MH, Joosten, LAB, Groh, LA, Riksen, NP, Espevik, T, Schlitzer, A, Li, Y, Fitzgerald, ML, Netea, MG, Schultze, JL and Latz, E
  
• (2019) Alternative splicing regulates stochastic NLRP3 activity; Nat Commun 10, 3238
  Hoss, F, Mueller, JL, Rojas Ringeling, F, Rodriguez-Alcazar, JF, Brinkschulte, R, Seifert, G, Stahl, R, Broderick, L, Putnam, CD, Kolodner, RD, Canzar, S, Geyer, M, Hoffman, HM and Latz, E
  
• (2019) Emerging Principles in Myelopoiesis at Homeostasis and during Infection and Inflammation; Immunity 50, 288-301
  Schultze, JL, Mass, E and Schlitzer, A
  
• (2019) Multi-omics identify xanthine as a pro-survival metabolite for nematodes with mitochondrial dysfunction; EMBO J 38, e99558
  Gioran, A, Piazzesi, A, Bertan, F, Schroer, J, Wischhof, L, Nicotera, P and Bano, D
  
• (2019) Tissue-resident memory CD8(+) T cells promote melanoma-immune equi- librium in skin; Nature 565, 366-371
  McConville, R, Wilmott, JS, Scolyer, RA, Tuting, T, Palendira, U, Gyorki, D, Mueller, SN, Huntington, ND, Bedoui, S, Holzel, M, Mackay, LK, Waithman, J and Gebhardt, T
  
• (2019) Variant PADI3 in Central Centrifugal Cicatricial Alopecia; N Engl J Med 380, 833-841
  Malki, L, Sarig, O, Romano, MT, Mechin, MC, Peled, A, Pavlovsky, M, Warshauer, E, Samuelov, L, Uwakwe, L, Briskin, V, Mohamad, J, Gat, A, Isakov, O, Rabinowitz, T, Shomron, N, Adir, N, Simon, M, McMichael, A, Dlova, NC, Betz, RC and Sprecher, E