GSC 1091:  Berlin School of Integrative Oncology (BSIO)

• Subject Area: Medicine
• Term: from 2012 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 194676614

• Final Report Year: 2020

Final Report Abstract

Cancer is a leading cause of death, its incidence linked to aging, a significant challenge for public health, and a major societal threat. Novel therapies that extend cancer patient survival and improve quality of life are the product of decades of intense research. Only concerted scientific efforts in sufficiently supported interdisciplinary research networks and more effective educative structures will further advance clinical cancer care. Molecular and translational oncology represents an internationally visible, dedicated core area of research at the Charité - Universitätsmedizin Berlin (Charité), which is underscored by the level of publications, German Research Foundation (DFG)-funded program projects, the newly established German Consortium for Translational Cancer Research (DKTK), the Charité Comprehensive Cancer Center (CCCC), and numerous cancer-related graduate colleges. To further improve research and training in this central medical area with cross-sectional implications for many other fields, the Charité and its mother universities, the Humboldt-Universität (HU) and the Freie Universität (FU), together with five high-profile non-university partner institutions, applied for an international graduate school and research network that integrates basic cancer biology and translational, applicable oncology, termed the “Berlin School of Integrative Oncology (BSIO)”, which was successfully established within the Excellence Initiative (ExIni) in the year 2012. Classic university degree programs in natural sciences or human medicine no longer meet the increasingly complex demands of “personalized cancer medicine” – the emerging goal of treating patients based on their individual molecular tumor determinants. Scientifically, the BSIO, embedded in a strong network of biomedical research expertise in the Berlin metropolitan area, seeks to advance our understanding of malignant growth to new conceptual levels by pioneering experimental and simulatory models that lead to novel diagnostics and innovative therapeutic principles and to make them rapidly available for clinical testing. Regarding its educational goals, the BSIO aims to sharpen scientific thinking and problem solving and offers an interdisciplinary training curriculum in an inspiring environment with novel degree opportunities and various incentives to promote early career development, especially for young female scientists. As its central mission, the BSIO aims to train young Ph.D. and medical graduate students and postgraduate fellows “at the same bench and in the same language”, thereby forming a next generation of cancer researchers for whom barriers of understanding between physicians and natural scientists no longer exist. It is the belief and vision of the BSIO that only the best trained scientists and clinicians capable of seamlessly communicating with each other will cooperatively identify the most demanding problems in clinical oncology, convert them into experimental approaches, unveil underlying mechanisms, and ultimately develop together conceptually novel therapies that will contribute to the elimination of cancer in the clinic.

Link to the final report

https://doi.org/10.2314/KXP:1741402778

Publications

• (2013). Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. Nature, 501(7467), 421-425
  Dorr, J. R., Yu, Y., Milanovic, M., Beuster, G., Zasada, C., Dabritz, J. H., . . . Schmitt, C. A.
  (See online at https://doi.org/10.1038/nature12437)
• (2014). BMP2-induced chemotaxis requires PI3K p55gamma/p110alpha-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5beta recruitment at the cytocortex. BMC Biol, 12, 43
  Hiepen, C., Benn, A., Denkis, A., Lukonin, I., Weise, C., Boergermann, J. H., & Knaus, P.
  (See online at https://doi.org/10.1186/1741-7007-12-43)
• (2015). A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer. Cancer Cell, 28(6), 743-757
  von Eyss, B., Jaenicke, L. A., Kortlever, R. M., Royla, N., Wiese, K. E., Letschert, S., . . . Eilers, M.
  (See online at https://doi.org/10.1016/j.ccell.2015.10.013)
• (2015). Assembly of a comprehensive regulatory network for the mammalian circadian clock: a bioinformatics approach. PLoS One, 10(5), e0126283
  Lehmann, R., Childs, L., Thomas, P., Abreu, M., Fuhr, L., Herzel, H., . . . Relogio, A.
  (See online at https://doi.org/10.1371/journal.pone.0126283)
• (2015). Circadian systems biology: When time matters. Comput Struct Biotechnol J, 13, 417-426
  Fuhr, L., Abreu, M., Pett, P., & Relogio, A.
  (See online at https://doi.org/10.1016/j.csbj.2015.07.001)
• (2015). Impact of peripheral myeloid cells on amyloid-beta pathology in Alzheimer's disease-like mice. J Exp Med, 212(11), 1811-1818
  Prokop, S., Miller, K. R., Drost, N., Handrick, S., Mathur, V., Luo, J., . . . Heppner, F. L.
  (See online at https://doi.org/10.1084/jem.20150479)
• (2015). Mutational dynamics between primary and relapse neuroblastomas. Nat Genet, 47(8), 872-877
  Schramm, A., Koster, J., Assenov, Y., Althoff, K., Peifer, M., Mahlow, E., . . . Schulte, J. H.
  (See online at https://doi.org/10.1038/ng.3349)
• (2015). PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones. Immunity, 43(6), 1075-1086
  Sander, S., Chu, V. T., Yasuda, T., Franklin, A., Graf, R., Calado, D. P., . . . Rajewsky, K.
  (See online at https://doi.org/10.1016/j.immuni.2015.10.021)
• (2016). Automated Annotation and Evaluation of In-Source Mass Spectra in GC/Atmospheric Pressure Chemical Ionization- MS-Based Metabolomics. Anal Chem, 88(19), 9386-9390
  Jaeger, C., Hoffmann, F., Schmitt, C. A., & Lisec, J.
  (See online at https://doi.org/10.1021/acs.analchem.6b02743)
• (2016). Clock genes-dependent acetylation of complex I sets rhythmic activity of mitochondrial OxPhos. Biochim Biophys Acta, 1863(4), 596-606
  Cela, O., Scrima, R., Pazienza, V., Merla, G., Benegiamo, G., Augello, B., . . . Capitanio, N.
  (See online at https://doi.org/10.1016/j.bbamcr.2015.12.018)
• (2016). Clock-genes and mitochondrial respiratory activity: Evidence of a reciprocal interplay. Biochim Biophys Acta, 1857(8), 1344-1351
  Scrima, R., Cela, O., Merla, G., Augello, B., Rubino, R., Quarato, G., . . . Capitanio, N.
  (See online at https://doi.org/10.1016/j.bbabio.2016.03.035)
• (2016). Extending the Dynamic Range in Metabolomics Experiments by Automatic Correction of Peaks Exceeding the Detection Limit. Anal Chem, 88(15), 7487-7492
  Lisec, J., Hoffmann, F., Schmitt, C., & Jaeger, C.
  (See online at https://doi.org/10.1021/acs.analchem.6b02515)
• (2016). Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer. Cancer Cell, 29(1), 17-31
  Serresi, M., Gargiulo, G., Proost, N., Siteur, B., Cesaroni, M., Koppens, M., . . . van Lohuizen, M.
  (See online at https://doi.org/10.1016/j.ccell.2015.12.006)
• (2016). The CUE Domain of Cue1 Aligns Growing Ubiquitin Chains with Ubc7 for Rapid Elongation. Mol Cell, 62(6), 918-928
  von Delbruck, M., Kniss, A., Rogov, V. V., Pluska, L., Bagola, K., Lohr, F., . . . Dotsch, V.
  (See online at https://doi.org/10.1016/j.molcel.2016.04.031)
• (2016). The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases. Mediators Inflamm, 2016, 2053646
  Egners, A., Erdem, M., & Cramer, T.
  (See online at https://doi.org/10.1155/2016/2053646)
• (2016). VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling. J Cell Sci, 129(1), 206- 218
  Benn, A., Bredow, C., Casanova, I., Vukicevic, S., & Knaus, P.
  (See online at https://doi.org/10.1242/jcs.179960)
• (2017). A compendium of ERK targets. FEBS Lett, 591(17), 2607-2615
  Unal, E. B., Uhlitz, F., & Bluthgen, N.
  (See online at https://doi.org/10.1002/1873-3468.12740)
• (2017). Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape. Leukemia, 31(7), 1640-1644
  Silva, P., Neumann, M., Schroeder, M. P., Vosberg, S., Schlee, C., Isaakidis, K., . . . Baldus, C. D.
  (See online at https://doi.org/10.1038/leu.2017.109)
• (2017). An immediate-late gene expression module decodes ERK signal duration. Mol Syst Biol, 13(9), 944
  Uhlitz, F., Sieber, A., Wyler, E., Fritsche-Guenther, R., Meisig, J., Landthaler, M., . . . Bluthgen, N.
  (See online at https://doi.org/10.15252/msb.20177986)
• (2017). Approaches and techniques to characterize cancer metabolism in vitro and in vivo. Biochim Biophys Acta Rev Cancer, 1868(2), 412-419
  Zaimenko, I., Lisec, J., Stein, U., & Brenner, W.
  (See online at https://doi.org/10.1016/j.bbcan.2017.08.004)
• (2017). Estimating genome-wide regulatory activity from multi-omics data sets using mathematical optimization. BMC Syst Biol, 11(1), 41
  Trescher, S., Munchmeyer, J., & Leser, U.
  (See online at https://doi.org/10.1186/s12918-017-0419-z)
• (2017). Initiation of acute graft-versus-host disease by angiogenesis. Blood, 129(14), 2021-2032
  Riesner, K., Shi, Y., Jacobi, A., Krater, M., Kalupa, M., McGearey, A., . . . Penack, O.
  (See online at https://doi.org/10.1182/blood-2016-08-736314)
• (2017). MACC1 regulates Fas mediated apoptosis through STAT1/3 - Mcl-1 signaling in solid cancers. Cancer Lett, 403, 231-245
  Radhakrishnan, H., Ilm, K., Walther, W., Shirasawa, S., Sasazuki, T., Daniel, P. T., . . . Stein, U.
  (See online at https://doi.org/10.1016/j.canlet.2017.06.020)
• (2017). Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner. Cell Mol Immunol, 14(7), 597-606
  Xu, X., Meng, Q., Erben, U., Wang, P., Glauben, R., Kuhl, A. A., . . . Qin, Z.
  (See online at https://doi.org/10.1038/cmi.2015.103)
• (2017). Oleate but not stearate induces the regulatory phenotype of myeloid suppressor cells. Sci Rep, 7(1), 7498
  Wu, H., Weidinger, C., Schmidt, F., Keye, J., Friedrich, M., Yerinde, C., . . . Glauben, R.
  (See online at https://doi.org/10.1038/s41598-017-07685-9)
• (2017). Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma. Blood, 129(1), 71-81
  Du, J., Neuenschwander, M., Yu, Y., Dabritz, J. H., Neuendorff, N. R., Schleich, K., . . . Schmitt, C. A.
  (See online at https://doi.org/10.1182/blood-2016-02-700773)
• (2017). Protein-Templated Fragment Ligations-From Molecular Recognition to Drug Discovery. Angew Chem Int Ed Engl, 56(26), 7358-7378
  Jaegle, M., Wong, E. L., Tauber, C., Nawrotzky, E., Arkona, C., & Rademann, J.
  (See online at https://doi.org/10.1002/anie.201610372)
• (2017). Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery. Eur J Pharm Biopharm, 116, 31-37
  Muller, F., Honzke, S., Luthardt, W. O., Wong, E. L., Unbehauen, M., Bauer, J., . . . Rademann, J.
  (See online at https://doi.org/10.1016/j.ejpb.2016.12.013)
• (2017). RITA displays anti-tumor activity in medulloblastomas independent of TP53 status. Oncotarget, 8(17), 27882-27891
  Gottlieb, A., Althoff, K., Grunewald, L., Thor, T., Odersky, A., Schulte, M., . . . Kunkele, A.
  (See online at https://doi.org/10.18632/oncotarget.15840)
• (2017). Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptordependent signaling pathways balance stalk vs. tip cell competence. FASEB J, 31(11), 4720-4733
  Benn, A., Hiepen, C., Osterland, M., Schutte, C., Zwijsen, A., & Knaus, P.
  (See online at https://doi.org/10.1096/fj.201700193RR)
• (2017). Salt-responsive gut commensal modulates TH17 axis and disease. Nature, 551(7682), 585-589
  Wilck, N., Matus, M. G., Kearney, S. M., Olesen, S. W., Forslund, K., Bartolomaeus, H., . . . Muller, D. N.
  (See online at https://doi.org/10.1038/nature24628)
• (2017). The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance. Mol Cell Oncol, 4(4), e1338209
  Royla, N., & Kempa, S.
  (See online at https://doi.org/10.1080/23723556.2017.1338209)
• (2017). The Drosophila embryo at single-cell transcriptome resolution. Science, 358(6360), 194-199
  Karaiskos, N., Wahle, P., Alles, J., Boltengagen, A., Ayoub, S., Kipar, C., . . . Zinzen, R. P.
  (See online at https://doi.org/10.1126/science.aan3235)
• (2017). The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity. PLoS Biol, 15(12), e2002940
  El-Athman, R., Genov, N. N., Mazuch, J., Zhang, K., Yu, Y., Fuhr, L., . . . Relogio, A.
  (See online at https://doi.org/10.1371/journal.pbio.2002940)
• (2017). The MYC mRNA 3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels. EMBO J, 36(13), 1854-1868
  Dejure, F. R., Royla, N., Herold, S., Kalb, J., Walz, S., Ade, C. P., . . . Eilers, M.
  (See online at https://doi.org/10.15252/embj.201796662)
• (2017). Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors. Sci Transl Med, 9(414)
  Henssen, A. G., Reed, C., Jiang, E., Garcia, H. D., von Stebut, J., MacArthur, I. C., . . . Kentsis, A.
  (See online at https://doi.org/10.1126/scitranslmed.aam9078)
• (2017). Tissue Specific Labeling in Proteomics. Proteomes, 5(3)
  Ramberger, E., & Dittmar, G.
  (See online at https://doi.org/10.3390/proteomes5030017)
• (2017). Translation of CircRNAs. Mol Cell, 66(1), 9-21 e27
  Pamudurti, N. R., Bartok, O., Jens, M., Ashwal-Fluss, R., Stottmeister, C., Ruhe, L., . . . Kadener, S.
  (See online at https://doi.org/10.1016/j.molcel.2017.02.021)
• (2018) Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells. Genes Dev. 1;32(9-10):645-657
  Kim M, Wende H, Walcher J, Kühnemund J, Cheret C, Kempa S, McShane E, Selbach M, Lewin GR, Birchmeier C.
  (See online at https://doi.org/10.1101/gad.310490.117)
• (2018) Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs. Cell 20;175(1):239-253.e17
  Meyer K, Kirchner M, … Willnow TE, Akalin A, Haucke V, Gerhardt H, Birchmeier C, Kühn R, Krauss M, Diecke S, Pascual JM, Selbach M
  (See online at https://doi.org/10.1016/j.cell.2018.08.019)
• (2018). ["Dr. Google"-informationseeking behavior and disease-specific anxiety among men with localized prostate cancer]. Urologe A
  Hilger, C., Otto, I., Hill, C., Huber, T., & Kendel, F.
  (See online at https://doi.org/10.1007/s00120-018-0769-1)
• (2018). A comparative analysis of human bone marrow-resident and peripheral memory B cells. J Allergy Clin Immunol, 141(5), 1911-1913 e1917
  Becker, S. C., Szyska, M., Mensen, A., Hellwig, K., Otto, R., Olfe, L., . . . Na, I. K.
  (See online at https://doi.org/10.1016/j.jaci.2017.12.983)
• (2018). A mechanistic classification of clinical phenotypes in neuroblastoma. Science, 362(6419), 1165-1170
  Ackermann, S., Cartolano, M., Hero, B., Welte, A., Kahlert, Y., Roderwieser, A., . . . Fischer, M.
  (See online at https://doi.org/10.1126/science.aat6768)
• (2018). A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer. EBioMedicine, 33, 68-81
  El-Athman, R., Fuhr, L., & Relogio, A.
  (See online at https://doi.org/10.1016/j.ebiom.2018.06.012)
• (2018). A Transgenic Dual-Luciferase Reporter Mouse for Longitudinal and Functional Monitoring of T Cells In Vivo. Cancer Immunol Res, 6(1), 110-120
  Szyska, M., Herda, S., Althoff, S., Heimann, A., Russ, J., D'Abundo, D., . . . Na, I. K.
  (See online at https://doi.org/10.1158/2326-6066.CIR-17-0256)
• (2018). Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations. Sci Rep, 8(1), 9204
  Fritsche-Guenther, R., Zasada, C., Mastrobuoni, G., Royla, N., Rainer, R., Rossner, F., . . . Kempa, S.
  (See online at https://doi.org/10.1038/s41598-018-27394-1)
• (2018). Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations. Acta Neuropathol, 136(2), 273-291
  Reinhardt, A., Stichel, D., Schrimpf, D., Sahm, F., Korshunov, A., Reuss, D. E., . . . Capper, D.
  (See online at https://doi.org/10.1007/s00401-018-1837-8)
• (2018). Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics. Science, 360(6391)
  Plass, M., Solana, J., Wolf, F. A., Ayoub, S., Misios, A., Glazar, P., . . . Rajewsky, N.
  (See online at https://doi.org/10.1126/science.aaq1723)
• (2018). Chain Assembly and Disassembly Processes Differently Affect the Conformational Space of Ubiquitin Chains. Structure, 26(2), 249-258 e244
  Kniss, A., Schuetz, D., Kazemi, S., Pluska, L., Spindler, P. E., Rogov, V. V., . . . Dotsch, V.
  (See online at https://doi.org/10.1016/j.str.2017.12.011)
• (2018). CNS myeloid cells critically regulate heat hyperalgesia. J Clin Invest, 128(7), 2774-2786
  Kalin, S., Miller, K. R., Kalin, R. E., Jendrach, M., Witzel, C., & Heppner, F. L.
  (See online at https://doi.org/10.1172/JCI95305)
• (2018). DNA methylation-based classification of central nervous system tumours. Nature, 555(7697), 469-474
  Capper, D., Jones, D. T. W., Sill, M., Hovestadt, V., Schrimpf, D., Sturm, D., . . . Pfister, S. M.
  (See online at https://doi.org/10.1038/nature26000)
• (2018). ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice. Cancer Res, 78(12), 3243-3254
  Schmidt, K., Keller, C., Kuhl, A. A., Textor, A., Seifert, U., Blankenstein, T., . . . Kloetzel, P. M.
  (See online at https://doi.org/10.1158/0008-5472.CAN-17-1946)
• (2018). Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities. J Exp Med, 215(12), 3115-3135
  Serresi, M., Siteur, B., Hulsman, D., Company, C., Schmitt, M. J., Lieftink, C., . . . Gargiulo, G.
  (See online at https://doi.org/10.1084/jem.20180801)
• (2018). Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis. Leukemia, 32(9), 1908-1919
  Arends, C. M., Galan-Sousa, J., Hoyer, K., Chan, W., Jager, M., Yoshida, K., . . . Damm, F.
  (See online at https://doi.org/10.1038/s41375-018-0047-7)
• (2018). MACC1-the first decade of a key metastasis molecule from gene discovery to clinical translation. Cancer Metastasis Rev, 37(4), 805-820
  Radhakrishnan, H., Walther, W., Zincke, F., Kobelt, D., Imbastari, F., Erdem, M., . . . Stein, U.
  (See online at https://doi.org/10.1007/s10555-018-9771-8)
• (2018). Nontargeted Identification of Tracer Incorporation in High-Resolution Mass Spectrometry. Anal Chem, 90(12), 7253-7260
  Hoffmann, F., Jaeger, C., Bhattacharya, A., Schmitt, C. A., & Lisec, J.
  (See online at https://doi.org/10.1021/acs.analchem.8b00356)
• (2018). Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells. Blood, 132(25), 2670-2683
  Kabrani, E., Chu, V. T., Tasouri, E., Sommermann, T., Bassler, K., Ulas, T., . . . Sander, S.
  (See online at https://doi.org/10.1182/blood-2018-06-856203)
• (2018). Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice. Blood, 132(9), 924-934
  Hoser, D., Schon, C., Loddenkemper, C., Lohneis, P., Kuhl, A. A., Sommermann, T., . . . Willimsky, G.
  (See online at https://doi.org/10.1182/blood-2018-02-834036)
• (2018). Oncogenic MYD88 mutations in lymphoma: novel insights and therapeutic possibilities. Cancer Immunol Immunother, 67(11), 1797-1807
  Weber, A. N. R., Cardona Gloria, Y., Cinar, O., Reinhardt, H. C., Pezzutto, A., & Wolz, O. O.
  (See online at https://doi.org/10.1007/s00262-018-2242-9)
• (2018). Perturbation-response genes reveal signaling footprints in cancer gene expression. Nat Commun, 9(1), 20
  Schubert, M., Klinger, B., Klunemann, M., Sieber, A., Uhlitz, F., Sauer, S., . . . Saez- Rodriguez, J.
  (See online at https://doi.org/10.1038/s41467-017-02391-6)
• (2018). Senescence-associated reprogramming promotes cancer stemness. Nature, 553(7686), 96-100
  Milanovic, M., Fan, D. N. Y., Belenki, D., Dabritz, J. H. M., Zhao, Z., Yu, Y., . . . Schmitt, C. A.
  (See online at https://doi.org/10.1038/nature25167)
• (2018). Systematic Analysis of Mouse Genome Reveals Distinct Evolutionary and Functional Properties Among Circadian and Ultradian Genes. Front Physiol, 9, 1178
  Castellana, S., Mazza, T., Capocefalo, D., Genov, N., Biagini, T., Fusilli, C., . . . Mazzoccoli, G.
  (See online at https://doi.org/10.3389/fphys.2018.01178)
• (2018). Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. Cancer Cell, 33(2), 322-336 e328
  Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., . . . Lee, S.
  (See online at https://doi.org/10.1016/j.ccell.2018.01.002)
• (2018). The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma. Leukemia, 32(9), 1994-2007
  Schleussner, N., Merkel, O., Costanza, M., Liang, H. C., Hummel, F., Romagnani, C., . . . Mathas, S.
  (See online at https://doi.org/10.1038/s41375-018-0045-9)
• (2018). The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination. Mol Cell, 72(4), 636-649 e638
  Delgado-Benito, V., Rosen, D. B., Wang, Q., Gazumyan, A., Pai, J. A., Oliveira, T. Y., . . . Di Virgilio, M.
  (See online at https://doi.org/10.1016/j.molcel.2018.08.042)
• (2018). The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer. EBioMedicine, 33, 105-121
  Fuhr, L., El-Athman, R., Scrima, R., Cela, O., Carbone, A., Knoop, H., . . . Relogio, A.
  (See online at https://doi.org/10.1016/j.ebiom.2018.07.002)
• (2018). The IkappaB kinase complex is a regulator of mRNA stability. EMBO J, 37(24)
  Mikuda, N., Kolesnichenko, M., Beaudette, P., Popp, O., Uyar, B., Sun, W., . . . Scheidereit, C.
  (See online at https://doi.org/10.15252/embj.201798658)
• (2018). The reciprocal interplay between TNFalpha and the circadian clock impacts on cell proliferation and migration in Hodgkin lymphoma cells. Sci Rep, 8(1), 11474
  Abreu, M., Basti, A., Genov, N., Mazzoccoli, G., & Relogio, A.
  (See online at https://doi.org/10.1038/s41598-018-29847-z)
• (2019) Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma. Blood. 2019 Mar 28;133(13):1489-1494
  von Hoff L, Kärgel E, …Schleussner N, Kolesnichenko M, Hübner N, Daumke O, Selbach M, Akalin A, Mathas S, Scheidereit C
  (See online at https://doi.org/10.1182/blood-2018-08-871293)
• (2019) Intracellular expression of FLT3 in Purkinje cells: implications for adoptive T-cell therapies. Leukemia. 2019 Apr;33(4):1039-1043
  Çakmak-Görür N, Radke J… Willimsky G, Heppner FL, Blankenstein T, Pezzutto A
  (See online at https://doi.org/10.1038/s41375-018-0330-7)
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