GSC 1091:  Berlin School of Integrative Oncology (BSIO)

• Subject Area: Medicine
• Term: from 2012 to 2019
• Project identifier: Deutsche Forschungsgemeinschaft (DFG) - Project number 194676614

• Final Report Year: 2020

Final Report Abstract

Cancer is a leading cause of death, its incidence linked to aging, a significant challenge for public health, and a major societal threat. Novel therapies that extend cancer patient survival and improve quality of life are the product of decades of intense research. Only concerted scientific efforts in sufficiently supported interdisciplinary research networks and more effective educative structures will further advance clinical cancer care. Molecular and translational oncology represents an internationally visible, dedicated core area of research at the Charité - Universitätsmedizin Berlin (Charité), which is underscored by the level of publications, German Research Foundation (DFG)-funded program projects, the newly established German Consortium for Translational Cancer Research (DKTK), the Charité Comprehensive Cancer Center (CCCC), and numerous cancer-related graduate colleges. To further improve research and training in this central medical area with cross-sectional implications for many other fields, the Charité and its mother universities, the Humboldt-Universität (HU) and the Freie Universität (FU), together with five high-profile non-university partner institutions, applied for an international graduate school and research network that integrates basic cancer biology and translational, applicable oncology, termed the “Berlin School of Integrative Oncology (BSIO)”, which was successfully established within the Excellence Initiative (ExIni) in the year 2012. Classic university degree programs in natural sciences or human medicine no longer meet the increasingly complex demands of “personalized cancer medicine” – the emerging goal of treating patients based on their individual molecular tumor determinants. Scientifically, the BSIO, embedded in a strong network of biomedical research expertise in the Berlin metropolitan area, seeks to advance our understanding of malignant growth to new conceptual levels by pioneering experimental and simulatory models that lead to novel diagnostics and innovative therapeutic principles and to make them rapidly available for clinical testing. Regarding its educational goals, the BSIO aims to sharpen scientific thinking and problem solving and offers an interdisciplinary training curriculum in an inspiring environment with novel degree opportunities and various incentives to promote early career development, especially for young female scientists. As its central mission, the BSIO aims to train young Ph.D. and medical graduate students and postgraduate fellows “at the same bench and in the same language”, thereby forming a next generation of cancer researchers for whom barriers of understanding between physicians and natural scientists no longer exist. It is the belief and vision of the BSIO that only the best trained scientists and clinicians capable of seamlessly communicating with each other will cooperatively identify the most demanding problems in clinical oncology, convert them into experimental approaches, unveil underlying mechanisms, and ultimately develop together conceptually novel therapies that will contribute to the elimination of cancer in the clinic.

Link to the final report

https://doi.org/10.2314/KXP:1741402778

Publications

• (2013). Synthetic lethal metabolic targeting of cellular senescence in cancer therapy. Nature, 501(7467), 421-425
  Dorr, J. R., Yu, Y., Milanovic, M., Beuster, G., Zasada, C., Dabritz, J. H., . . . Schmitt, C. A.
  
• (2014). BMP2-induced chemotaxis requires PI3K p55gamma/p110alpha-dependent phosphatidylinositol (3,4,5)-triphosphate production and LL5beta recruitment at the cytocortex. BMC Biol, 12, 43
  Hiepen, C., Benn, A., Denkis, A., Lukonin, I., Weise, C., Boergermann, J. H., & Knaus, P.
  
• (2015). A MYC-Driven Change in Mitochondrial Dynamics Limits YAP/TAZ Function in Mammary Epithelial Cells and Breast Cancer. Cancer Cell, 28(6), 743-757
  von Eyss, B., Jaenicke, L. A., Kortlever, R. M., Royla, N., Wiese, K. E., Letschert, S., . . . Eilers, M.
  
• (2015). Assembly of a comprehensive regulatory network for the mammalian circadian clock: a bioinformatics approach. PLoS One, 10(5), e0126283
  Lehmann, R., Childs, L., Thomas, P., Abreu, M., Fuhr, L., Herzel, H., . . . Relogio, A.
  
• (2015). Circadian systems biology: When time matters. Comput Struct Biotechnol J, 13, 417-426
  Fuhr, L., Abreu, M., Pett, P., & Relogio, A.
  
• (2015). Impact of peripheral myeloid cells on amyloid-beta pathology in Alzheimer's disease-like mice. J Exp Med, 212(11), 1811-1818
  Prokop, S., Miller, K. R., Drost, N., Handrick, S., Mathur, V., Luo, J., . . . Heppner, F. L.
  
• (2015). Mutational dynamics between primary and relapse neuroblastomas. Nat Genet, 47(8), 872-877
  Schramm, A., Koster, J., Assenov, Y., Althoff, K., Peifer, M., Mahlow, E., . . . Schulte, J. H.
  
• (2015). PI3 Kinase and FOXO1 Transcription Factor Activity Differentially Control B Cells in the Germinal Center Light and Dark Zones. Immunity, 43(6), 1075-1086
  Sander, S., Chu, V. T., Yasuda, T., Franklin, A., Graf, R., Calado, D. P., . . . Rajewsky, K.
  
• (2016). Automated Annotation and Evaluation of In-Source Mass Spectra in GC/Atmospheric Pressure Chemical Ionization- MS-Based Metabolomics. Anal Chem, 88(19), 9386-9390
  Jaeger, C., Hoffmann, F., Schmitt, C. A., & Lisec, J.
  
• (2016). Clock genes-dependent acetylation of complex I sets rhythmic activity of mitochondrial OxPhos. Biochim Biophys Acta, 1863(4), 596-606
  Cela, O., Scrima, R., Pazienza, V., Merla, G., Benegiamo, G., Augello, B., . . . Capitanio, N.
  
• (2016). Clock-genes and mitochondrial respiratory activity: Evidence of a reciprocal interplay. Biochim Biophys Acta, 1857(8), 1344-1351
  Scrima, R., Cela, O., Merla, G., Augello, B., Rubino, R., Quarato, G., . . . Capitanio, N.
  
• (2016). Extending the Dynamic Range in Metabolomics Experiments by Automatic Correction of Peaks Exceeding the Detection Limit. Anal Chem, 88(15), 7487-7492
  Lisec, J., Hoffmann, F., Schmitt, C., & Jaeger, C.
  
• (2016). Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer. Cancer Cell, 29(1), 17-31
  Serresi, M., Gargiulo, G., Proost, N., Siteur, B., Cesaroni, M., Koppens, M., . . . van Lohuizen, M.
  
• (2016). The CUE Domain of Cue1 Aligns Growing Ubiquitin Chains with Ubc7 for Rapid Elongation. Mol Cell, 62(6), 918-928
  von Delbruck, M., Kniss, A., Rogov, V. V., Pluska, L., Bagola, K., Lohr, F., . . . Dotsch, V.
  
• (2016). The Response of Macrophages and Neutrophils to Hypoxia in the Context of Cancer and Other Inflammatory Diseases. Mediators Inflamm, 2016, 2053646
  Egners, A., Erdem, M., & Cramer, T.
  
• (2016). VE-cadherin facilitates BMP-induced endothelial cell permeability and signaling. J Cell Sci, 129(1), 206- 218
  Benn, A., Bredow, C., Casanova, I., Vukicevic, S., & Knaus, P.
  
• (2017). A compendium of ERK targets. FEBS Lett, 591(17), 2607-2615
  Unal, E. B., Uhlitz, F., & Bluthgen, N.
  
• (2017). Acute myeloid leukemia in the elderly is characterized by a distinct genetic and epigenetic landscape. Leukemia, 31(7), 1640-1644
  Silva, P., Neumann, M., Schroeder, M. P., Vosberg, S., Schlee, C., Isaakidis, K., . . . Baldus, C. D.
  
• (2017). An immediate-late gene expression module decodes ERK signal duration. Mol Syst Biol, 13(9), 944
  Uhlitz, F., Sieber, A., Wyler, E., Fritsche-Guenther, R., Meisig, J., Landthaler, M., . . . Bluthgen, N.
  
• (2017). Approaches and techniques to characterize cancer metabolism in vitro and in vivo. Biochim Biophys Acta Rev Cancer, 1868(2), 412-419
  Zaimenko, I., Lisec, J., Stein, U., & Brenner, W.
  
• (2017). Estimating genome-wide regulatory activity from multi-omics data sets using mathematical optimization. BMC Syst Biol, 11(1), 41
  Trescher, S., Munchmeyer, J., & Leser, U.
  
• (2017). Initiation of acute graft-versus-host disease by angiogenesis. Blood, 129(14), 2021-2032
  Riesner, K., Shi, Y., Jacobi, A., Krater, M., Kalupa, M., McGearey, A., . . . Penack, O.
  
• (2017). MACC1 regulates Fas mediated apoptosis through STAT1/3 - Mcl-1 signaling in solid cancers. Cancer Lett, 403, 231-245
  Radhakrishnan, H., Ilm, K., Walther, W., Shirasawa, S., Sasazuki, T., Daniel, P. T., . . . Stein, U.
  
• (2017). Myeloid-derived suppressor cells promote B-cell production of IgA in a TNFR2-dependent manner. Cell Mol Immunol, 14(7), 597-606
  Xu, X., Meng, Q., Erben, U., Wang, P., Glauben, R., Kuhl, A. A., . . . Qin, Z.
  
• (2017). Oleate but not stearate induces the regulatory phenotype of myeloid suppressor cells. Sci Rep, 7(1), 7498
  Wu, H., Weidinger, C., Schmidt, F., Keye, J., Friedrich, M., Yerinde, C., . . . Glauben, R.
  
• (2017). Pharmacological restoration and therapeutic targeting of the B-cell phenotype in classical Hodgkin lymphoma. Blood, 129(1), 71-81
  Du, J., Neuenschwander, M., Yu, Y., Dabritz, J. H., Neuendorff, N. R., Schleich, K., . . . Schmitt, C. A.
  
• (2017). Protein-Templated Fragment Ligations-From Molecular Recognition to Drug Discovery. Angew Chem Int Ed Engl, 56(26), 7358-7378
  Jaegle, M., Wong, E. L., Tauber, C., Nawrotzky, E., Arkona, C., & Rademann, J.
  
• (2017). Rhamnolipids form drug-loaded nanoparticles for dermal drug delivery. Eur J Pharm Biopharm, 116, 31-37
  Muller, F., Honzke, S., Luthardt, W. O., Wong, E. L., Unbehauen, M., Bauer, J., . . . Rademann, J.
  
• (2017). RITA displays anti-tumor activity in medulloblastomas independent of TP53 status. Oncotarget, 8(17), 27882-27891
  Gottlieb, A., Althoff, K., Grunewald, L., Thor, T., Odersky, A., Schulte, M., . . . Kunkele, A.
  
• (2017). Role of bone morphogenetic proteins in sprouting angiogenesis: differential BMP receptordependent signaling pathways balance stalk vs. tip cell competence. FASEB J, 31(11), 4720-4733
  Benn, A., Hiepen, C., Osterland, M., Schutte, C., Zwijsen, A., & Knaus, P.
  
• (2017). Salt-responsive gut commensal modulates TH17 axis and disease. Nature, 551(7682), 585-589
  Wilck, N., Matus, M. G., Kearney, S. M., Olesen, S. W., Forslund, K., Bartolomaeus, H., . . . Muller, D. N.
  
• (2017). The answer's in the tail: MYC mRNA has a metabolic sensor that supports cancer chemoresistance. Mol Cell Oncol, 4(4), e1338209
  Royla, N., & Kempa, S.
  
• (2017). The Drosophila embryo at single-cell transcriptome resolution. Science, 358(6360), 194-199
  Karaiskos, N., Wahle, P., Alles, J., Boltengagen, A., Ayoub, S., Kipar, C., . . . Zinzen, R. P.
  
• (2017). The Ink4a/Arf locus operates as a regulator of the circadian clock modulating RAS activity. PLoS Biol, 15(12), e2002940
  El-Athman, R., Genov, N. N., Mazuch, J., Zhang, K., Yu, Y., Fuhr, L., . . . Relogio, A.
  
• (2017). The MYC mRNA 3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels. EMBO J, 36(13), 1854-1868
  Dejure, F. R., Royla, N., Herold, S., Kalb, J., Walz, S., Ade, C. P., . . . Eilers, M.
  
• (2017). Therapeutic targeting of PGBD5-induced DNA repair dependency in pediatric solid tumors. Sci Transl Med, 9(414)
  Henssen, A. G., Reed, C., Jiang, E., Garcia, H. D., von Stebut, J., MacArthur, I. C., . . . Kentsis, A.
  
• (2017). Tissue Specific Labeling in Proteomics. Proteomes, 5(3)
  Ramberger, E., & Dittmar, G.
  
• (2017). Translation of CircRNAs. Mol Cell, 66(1), 9-21 e27
  Pamudurti, N. R., Bartok, O., Jens, M., Ashwal-Fluss, R., Stottmeister, C., Ruhe, L., . . . Kadener, S.
  
• (2018) Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells. Genes Dev. 1;32(9-10):645-657
  Kim M, Wende H, Walcher J, Kühnemund J, Cheret C, Kempa S, McShane E, Selbach M, Lewin GR, Birchmeier C.
  
• (2018) Mutations in Disordered Regions Can Cause Disease by Creating Dileucine Motifs. Cell 20;175(1):239-253.e17
  Meyer K, Kirchner M, … Willnow TE, Akalin A, Haucke V, Gerhardt H, Birchmeier C, Kühn R, Krauss M, Diecke S, Pascual JM, Selbach M
  
• (2018). ["Dr. Google"-informationseeking behavior and disease-specific anxiety among men with localized prostate cancer]. Urologe A
  Hilger, C., Otto, I., Hill, C., Huber, T., & Kendel, F.
  
• (2018). A comparative analysis of human bone marrow-resident and peripheral memory B cells. J Allergy Clin Immunol, 141(5), 1911-1913 e1917
  Becker, S. C., Szyska, M., Mensen, A., Hellwig, K., Otto, R., Olfe, L., . . . Na, I. K.
  
• (2018). A mechanistic classification of clinical phenotypes in neuroblastoma. Science, 362(6419), 1165-1170
  Ackermann, S., Cartolano, M., Hero, B., Welte, A., Kahlert, Y., Roderwieser, A., . . . Fischer, M.
  
• (2018). A Systems-Level Analysis Reveals Circadian Regulation of Splicing in Colorectal Cancer. EBioMedicine, 33, 68-81
  El-Athman, R., Fuhr, L., & Relogio, A.
  
• (2018). A Transgenic Dual-Luciferase Reporter Mouse for Longitudinal and Functional Monitoring of T Cells In Vivo. Cancer Immunol Res, 6(1), 110-120
  Szyska, M., Herda, S., Althoff, S., Heimann, A., Russ, J., D'Abundo, D., . . . Na, I. K.
  
• (2018). Alterations of mTOR signaling impact metabolic stress resistance in colorectal carcinomas with BRAF and KRAS mutations. Sci Rep, 8(1), 9204
  Fritsche-Guenther, R., Zasada, C., Mastrobuoni, G., Royla, N., Rainer, R., Rossner, F., . . . Kempa, S.
  
• (2018). Anaplastic astrocytoma with piloid features, a novel molecular class of IDH wildtype glioma with recurrent MAPK pathway, CDKN2A/B and ATRX alterations. Acta Neuropathol, 136(2), 273-291
  Reinhardt, A., Stichel, D., Schrimpf, D., Sahm, F., Korshunov, A., Reuss, D. E., . . . Capper, D.
  
• (2018). Cell type atlas and lineage tree of a whole complex animal by single-cell transcriptomics. Science, 360(6391)
  Plass, M., Solana, J., Wolf, F. A., Ayoub, S., Misios, A., Glazar, P., . . . Rajewsky, N.
  
• (2018). Chain Assembly and Disassembly Processes Differently Affect the Conformational Space of Ubiquitin Chains. Structure, 26(2), 249-258 e244
  Kniss, A., Schuetz, D., Kazemi, S., Pluska, L., Spindler, P. E., Rogov, V. V., . . . Dotsch, V.
  
• (2018). CNS myeloid cells critically regulate heat hyperalgesia. J Clin Invest, 128(7), 2774-2786
  Kalin, S., Miller, K. R., Kalin, R. E., Jendrach, M., Witzel, C., & Heppner, F. L.
  
• (2018). DNA methylation-based classification of central nervous system tumours. Nature, 555(7697), 469-474
  Capper, D., Jones, D. T. W., Sill, M., Hovestadt, V., Schrimpf, D., Sturm, D., . . . Pfister, S. M.
  
• (2018). ERAP1-Dependent Antigen Cross-Presentation Determines Efficacy of Adoptive T-cell Therapy in Mice. Cancer Res, 78(12), 3243-3254
  Schmidt, K., Keller, C., Kuhl, A. A., Textor, A., Seifert, U., Blankenstein, T., . . . Kloetzel, P. M.
  
• (2018). Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities. J Exp Med, 215(12), 3115-3135
  Serresi, M., Siteur, B., Hulsman, D., Company, C., Schmitt, M. J., Lieftink, C., . . . Gargiulo, G.
  
• (2018). Hematopoietic lineage distribution and evolutionary dynamics of clonal hematopoiesis. Leukemia, 32(9), 1908-1919
  Arends, C. M., Galan-Sousa, J., Hoyer, K., Chan, W., Jager, M., Yoshida, K., . . . Damm, F.
  
• (2018). MACC1-the first decade of a key metastasis molecule from gene discovery to clinical translation. Cancer Metastasis Rev, 37(4), 805-820
  Radhakrishnan, H., Walther, W., Zincke, F., Kobelt, D., Imbastari, F., Erdem, M., . . . Stein, U.
  
• (2018). Nontargeted Identification of Tracer Incorporation in High-Resolution Mass Spectrometry. Anal Chem, 90(12), 7253-7260
  Hoffmann, F., Jaeger, C., Bhattacharya, A., Schmitt, C. A., & Lisec, J.
  
• (2018). Nuclear FOXO1 promotes lymphomagenesis in germinal center B cells. Blood, 132(25), 2670-2683
  Kabrani, E., Chu, V. T., Tasouri, E., Sommermann, T., Bassler, K., Ulas, T., . . . Sander, S.
  
• (2018). Oncogene-specific T cells fail to eradicate lymphoma-initiating B cells in mice. Blood, 132(9), 924-934
  Hoser, D., Schon, C., Loddenkemper, C., Lohneis, P., Kuhl, A. A., Sommermann, T., . . . Willimsky, G.
  
• (2018). Oncogenic MYD88 mutations in lymphoma: novel insights and therapeutic possibilities. Cancer Immunol Immunother, 67(11), 1797-1807
  Weber, A. N. R., Cardona Gloria, Y., Cinar, O., Reinhardt, H. C., Pezzutto, A., & Wolz, O. O.
  
• (2018). Perturbation-response genes reveal signaling footprints in cancer gene expression. Nat Commun, 9(1), 20
  Schubert, M., Klinger, B., Klunemann, M., Sieber, A., Uhlitz, F., Sauer, S., . . . Saez- Rodriguez, J.
  
• (2018). Senescence-associated reprogramming promotes cancer stemness. Nature, 553(7686), 96-100
  Milanovic, M., Fan, D. N. Y., Belenki, D., Dabritz, J. H. M., Zhao, Z., Yu, Y., . . . Schmitt, C. A.
  
• (2018). Systematic Analysis of Mouse Genome Reveals Distinct Evolutionary and Functional Properties Among Circadian and Ultradian Genes. Front Physiol, 9, 1178
  Castellana, S., Mazza, T., Capocefalo, D., Genov, N., Biagini, T., Fusilli, C., . . . Mazzoccoli, G.
  
• (2018). Targeting the Senescence-Overriding Cooperative Activity of Structurally Unrelated H3K9 Demethylases in Melanoma. Cancer Cell, 33(2), 322-336 e328
  Yu, Y., Schleich, K., Yue, B., Ji, S., Lohneis, P., Kemper, K., . . . Lee, S.
  
• (2018). The AP-1-BATF and -BATF3 module is essential for growth, survival and TH17/ILC3 skewing of anaplastic large cell lymphoma. Leukemia, 32(9), 1994-2007
  Schleussner, N., Merkel, O., Costanza, M., Liang, H. C., Hummel, F., Romagnani, C., . . . Mathas, S.
  
• (2018). The Chromatin Reader ZMYND8 Regulates Igh Enhancers to Promote Immunoglobulin Class Switch Recombination. Mol Cell, 72(4), 636-649 e638
  Delgado-Benito, V., Rosen, D. B., Wang, Q., Gazumyan, A., Pai, J. A., Oliveira, T. Y., . . . Di Virgilio, M.
  
• (2018). The Circadian Clock Regulates Metabolic Phenotype Rewiring Via HKDC1 and Modulates Tumor Progression and Drug Response in Colorectal Cancer. EBioMedicine, 33, 105-121
  Fuhr, L., El-Athman, R., Scrima, R., Cela, O., Carbone, A., Knoop, H., . . . Relogio, A.
  
• (2018). The IkappaB kinase complex is a regulator of mRNA stability. EMBO J, 37(24)
  Mikuda, N., Kolesnichenko, M., Beaudette, P., Popp, O., Uyar, B., Sun, W., . . . Scheidereit, C.
  
• (2018). The reciprocal interplay between TNFalpha and the circadian clock impacts on cell proliferation and migration in Hodgkin lymphoma cells. Sci Rep, 8(1), 11474
  Abreu, M., Basti, A., Genov, N., Mazzoccoli, G., & Relogio, A.
  
• (2019) Autocrine LTA signaling drives NF-κB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma. Blood. 2019 Mar 28;133(13):1489-1494
  von Hoff L, Kärgel E, …Schleussner N, Kolesnichenko M, Hübner N, Daumke O, Selbach M, Akalin A, Mathas S, Scheidereit C
  
• (2019) Intracellular expression of FLT3 in Purkinje cells: implications for adoptive T-cell therapies. Leukemia. 2019 Apr;33(4):1039-1043
  Çakmak-Görür N, Radke J… Willimsky G, Heppner FL, Blankenstein T, Pezzutto A
  
• (2019) Isomorphic diffuse glioma is a morphologically and molecularly distinct tumour entity with recurrent gene fusions of MYBL1 or MYB and a benign disease course. Acta Neuropathol. 2019 Sep 28
  Wefers AK, Stichel D, Schrimpf D, …Schwarz D, Söylemezoglu F… Blumcke I, Capper D
  
• (2019) The kinetochore module Okp1CENP-Q/Ame1CENP-U is a reader for N-terminal modifications on the centromeric histone Cse4 CENP-A. EMBO J. 2019 Jan 3;38(1)
  Anedchenko EA, Samel-Pommerencke A, Tran Nguyen TM, Shahnejat-Bushehri S, Pöpsel J, Lauster D, Herrmann A, Rappsilber J, Cuomo A, Bonaldi T, Ehrenhofer-Murray AE
  
• (2019). [Facets of doctor-patient conversations in urological practice: recommendations for intervention from psycho-oncology]. Aktuelle Urol, 50(2), 172-178
  Kendel, F., & Hilger, C.
  
• (2019). Autocrine LTA signaling drives NF-kappaB and JAK-STAT activity and myeloid gene expression in Hodgkin lymphoma. Blood, 133(13), 1489-1494
  von Hoff, L., Kargel, E., Franke, V., McShane, E., Schulz-Beiss, K. W., Patone, G., . . . Scheidereit, C.
  
• (2019). Beclin1-driven autophagy modulates the inflammatory response of microglia via NLRP3. EMBO J, 38(4)
  Houtman, J., Freitag, K., Gimber, N., Schmoranzer, J., Heppner, F. L., & Jendrach, M.
  
• (2019). Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium. Nat Commun, 10(1), 2919
  Brandt, R., Sell, T., Luthen, M., Uhlitz, F., Klinger, B., Riemer, P., . . . Morkel, M.
  
• (2019). Cytotoxic Effects of Rabbit Anti-thymocyte Globulin Preparations on Primary Human Thymic Epithelial Cells. Transplantation 103(11)
  Kaebisch EM, Cho MY, … Reinke P, Volk HD, Gillissen B, Bullinger L, Thiel A, Na IK
  
• (2019). Diffusion-weighted magnetic resonance imaging using a preclinical 1 T PET/MRI in healthy and tumor-bearing rats. EJNMMI Res, 9(1), 21
  Albrecht, J., Polenz, D., Kuhl, A. A., Rogasch, J. M. M., Leder, A., Sauer, I. M., . . . Koziolek, E. J.
  
• (2019). Effective NY-ESO-1-specific MHC II-restricted T cell receptors from antigen-negative hosts enhance tumor regression. J Clin Invest. 2019 Jan 2;129(1):324-335
  Poncette L, Chen X, Lorenz FK, Blankenstein T
  
• (2019). EMT networkbased feature selection improves prognosis prediction in lung adenocarcinoma. PLoS One, 14(1), e0204186
  Shao, B., Bjaanaes, M. M., Helland, A., Schutte, C., & Conrad, T.
  
• (2019). Epigenetic regulation of Amphiregulin and Epiregulin in colorectal cancer. Int J Cancer, 144(3), 569-581
  Bormann, F., Stinzing, S., Tierling, S., Morkel, M., Markelova, M. R., Walter, J., . . . Sers, C.
  
• (2019). Estimation of Transcription Factor Activity in Knockdown Studies. Sci Rep, 9(1), 9593
  Trescher, S., & Leser, U.
  
• (2019). Genomic landscape and clonal evolution of acute myeloid leukemia with t(8;21): an international study on 331 patients. Blood, 133(10), 1140-1151
  Christen, F., Hoyer, K., Yoshida, K., Hou, H. A., Waldhueter, N., Heuser, M., . . . Damm, F.
  
• (2019). getITD for FLT3-ITD-based MRD monitoring in AML. Leukemia 33(10):2535-2539
  Blätte TJ, Schmalbrock LK, … Dolnik A, Döhner H, Döhner K, Bullinger L
  
• (2019). Haematologica (Epub)
  Arends CM, Weiss M, Christen F, …Hoyer K, Frick M, Bullinger L, Bieringer M, Schreiber A, Damm F
  
• (2019). HDAC inhibitors promote intestinal epithelial regeneration via autocrine TGFbeta1 signalling in inflammation. Mucosal Immunol, 12(3), 656-667
  Friedrich, M., Gerbeth, L., Gerling, M., Rosenthal, R., Steiger, K., Weidinger, C., . . . Glauben, R.
  
• (2019). Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry. Nat Neurosci, 22(1), 78-90
  Bottcher, C., Schlickeiser, S., Sneeboer, M. A. M., Kunkel, D., Knop, A., Paza, E., . . . Priller, J.
  
• (2019). Identification and characterization of a novel chemotype for human TLR8 inhibitors. Eur J Med Chem, 179, 744-752
  Sribar, D., Grabowski, M., Murgueitio, M. S., Bermudez, M., Weindl, G., & Wolber, G.
  
• (2019). Lipid droplet-dependent fatty acid metabolism controls the immune suppressive phenotype of tumor-associated macrophages. EMBO Mol Med. 2019 Oct 10:e10698
  Wu H, Han Y, Rodriguez Sillke Y, Deng H, Siddiqui S, Treese C, …Kühl AA, Qin Z, Siegmund B, Glauben R
  
• (2019). Localization-associated immune phenotypes of clonally expanded tumor-infiltrating T cells and distribution of their target antigens in rectal cancer. Oncoimmunology, 8(6), e1586409
  Penter, L., Dietze, K., Ritter, J., Lammoglia Cobo, M. F., Garmshausen, J., Aigner, F., . . . Hansmann, L.
  
• (2019). Non-canonical HIF-1 stabilization contributes to intestinal tumorigenesis. Oncogene, 38(28), 5670-5685
  Rohwer, N., Jumpertz, S., Erdem, M., Egners, A., Warzecha, K. T., Fragoulis, A., . . . Cramer, T.
  
• (2019). Non-invasive metastasis prognosis from plasma metabolites in stage II colorectal cancer patients: The DACHS study. Int J Cancer, 145(1), 221-231
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