Funktionelle Wechselwirkungen zwischen genomischer Instabilität und inhibierter Apoptose in hämatopoetischen Neoplasien

Applicant Privatdozentin Dr. Simone Böhrer

Subject Area Hematology, Oncology

Term from 2005 to 2007

Project identifier Deutsche Forschungsgemeinschaft (DFG) - Project number 19902994

Final Report Year 2008

Final Report Abstract

No abstract available

Differentiating megakaryocytes in myelodysplastic syndromes succumb to mitochondrial derangement without caspase activation. Apoptosis. 2007 Jun;12(6):1101-8
Braun T, Carvalho G, Grosjean J, Ades L, Fabre C, Boehrer S, Debili N, Fenaux P, and Guido Kroemer
Inhibition of NEMO, the regulatory subunit of the IKK complex, induces apoptosis in high-risk myelodysplastic syndrome and acute myeloid leukemia. Oncogene. 2007 Apr 5;26(16):2299-307
Carvalho G, Fabre C, Braun T, Grosjean J, Ades L, Agou F, Tasdemir E, Boehrer S, Israel A, Veron M, Fenaux P, and Guido Kroemer
NF-kappaB inhibition sensitizes to starvation-induced cell death in high-risk myeiodysplastic syndrome and acute myeloid leukemia. Oncogene. 2007 Jun 14;26(28):4071-83
Fabre C, Carvalho G, Tasdemir E, Braun T, Ades L, Grosjean J, Boehrer S, Metivier D, Souquere S, Pierron G, Fenaux P, and Guido Kroemer
Nonapoptotic role for Apaf-1 in the DMA damage checkpoint. Mol Cell. 2007 Nov 30;28(4):624-37
Zermati Y, Mouhamad S, Stergiou L, Besse B, Galluzzi L, Boehrer S, Pauleau AL, Rosselli F, D'Amelio M, Amendola R, Castedo M, Soria JC, Cecconi F, Kroemer G