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Projekt
Towards dissecting mechanisms of compatibility in plants and fungi; a systemsbiology approach combining transcriptome and metabolome data
Antragsteller
Professor Dr. Matthias Frisch; Professor Dr. Karl-Heinz Kogel
Fachliche Zuordnung
Pflanzenzüchtung, Pflanzenpathologie
Förderung
Förderung von 2006 bis 2015
Projektkennung
Deutsche Forschungsgemeinschaft (DFG) - Projektnummer 15847441
Major objective of this project is to provide the fundamentals for the net-based communication structure, central database management and the statistical analysis and interpretation of microarray and metabolome data within FOR 666. The project will (1) coordinate and guide the design of transcriptional and metabolic profiling experiments, will (2) be responsible for the central web-management system including a central database system as a basic tool for information flow, knowledge exchange and collaboration among the participating FOR groups. Beside internal communication the project will (3) build and maintain project s internet site as a means of outside representation of the whole FOR 666. B7 will comparatively analyse data sets from interaction experiments (Central Experiment) of the pathogens Ustilago maydis, Blumeria graminis, Colletotrichum graminicola and the symbiont Piriformospora indica with their respective hosts. This will include refining methods and optimising existing methods as well as bioinformatic tools and investigating new approaches in a close interdisciplinary collaboration with the FOR 666 sub-projects. Comparative analysis of data sets will include all the physiological, metabolic and transcriptional data obtained in FOR 666 and thus will provide findings about metabolic and molecular changes induced during compatible plant-microbe interaction processes. This knowledge is expected to enable the identification of key-metabolites and transcripts and allow the in silico modelling of regulatory networks that facilitate plant metabolic reprogramming processes. Insights derived within this project will improve experimental design for subsequent tests of mutant fungi and transgenic plants within the other sub-projects of FOR 666.
DFG-Verfahren
Forschungsgruppen
