Project Details
Projekt
Regulation of SH3 domain-based scaffolds in clathrin-mediated endocytosis (A07)
Subject Area
Biochemistry
Term
from 2011 to 2023
Project identifier
Deutsche Forschungsgemeinschaft (DFG) - Project number 184695641
In project A07 we have shown that the activation and function of intersectin-1 in synaptic vesicle recycling and of SNX9 in endocytosis is controlled by release from intramolecular autoinhibition. In the coming funding period, we will (i) unravel the structural basis of the interaction between intersectin-1 and the SNARE-complex, (ii) investigate the role of intersectin-1 in endocytic protein nanoscale localization and dynamics, and (iii) unravel the formation and function of the early endocytic intersectin-FCHo-Eps15 complex in clathrin-mediated endocytosis.
DFG Programme
Collaborative Research Centres
Applicant Institution
Freie Universität Berlin
Project Heads
Professor Dr. Christian Freund; Professor Volker Haucke, Ph.D.
